Advances in drug discovery for human beta cell regeneration

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

(2017) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas

(2017) Huan Wang et al.   Nature Communications

Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration

(2016) Kristie I. Aamodt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain?

(2016) Sergey Kasparov   Cell Metabolism

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function

(2016) H. Efsun Arda et al.   Cell Metabolism

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication

(2016) Sangeeta Dhawan et al.   DIABETES

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Novel factors modulating human β-cell proliferation

(2016) J. Shirakawa et al.   DIABETES OBESITY & METABOLISM

High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation

(2016) Karine Robitaille et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Human pancreatic beta-like cells converted from fibroblasts

(2016) Saiyong Zhu et al.   Nature Communications

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

(2016) Amanda M. Ackermann et al.   Molecular Metabolism

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway

(2015) Nagesha Guthalu Kondegowda et al.   Cell Metabolism

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function

(2015) Dana Avrahami et al.   Cell Metabolism

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Human β-Cell Proliferation and Intracellular Signaling: Part 3

(2015) Andrew F. Stewart et al.   DIABETES

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Diabetes mellitus—advances and challenges in human β-cell proliferation

(2015) Peng Wang et al.   Nature Reviews Endocrinology

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

GABA Promotes Human  -Cell Proliferation and Modulates Glucose Homeostasis

(2014) I. Purwana et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

(2014) E. Bernal-Mizrachi et al.   DIABETES

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Targeting the pancreatic β-cell to treat diabetes

(2014) Amedeo Vetere et al.   NATURE REVIEWS DRUG DISCOVERY

A Smad Signaling Network Regulates Islet Cell Proliferation

(2013) Y. El-Gohary et al.   DIABETES

Human Pancreatic  -Cell G1/S Molecule Cell Cycle Atlas

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human  -Cell Replication: A Revised Model of Human  -Cell G1/S Control

(2013) N. M. Fiaschi-Taesch et al.   DIABETES

Mortality in diabetes: pancreas transplantation is associated with significant survival benefit

(2013) D. van Dellen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Adenosine Signaling Promotes Regeneration of Pancreatic β Cells In Vivo

(2012) Olov Andersson et al.   Cell Metabolism

A VGF-Derived Peptide Attenuates Development of Type 2 Diabetes via Enhancement of Islet β-Cell Survival and Function

(2012) Samuel B. Stephens et al.   Cell Metabolism

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adenosine kinase inhibition selectively promotes rodent and porcine islet  -cell replication

(2012) J. P. Annes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developments in harmine pharmacology — Implications for ayahuasca use and drug-dependence treatment

(2012) Daniel I. Brierley et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating

(2010) S. Perl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Emerging roles for the TGFβ family in pancreatic β-cell homeostasis

(2010) Melissa L. Brown et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

(2010) Yasushi Ogawa et al.   Nature Communications

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

(2009) M. Cnop et al.   DIABETOLOGIA

Identification of small-molecule inducers of pancreatic  -cell expansion

(2009) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES