Generation of pancreatic β cells for treatment of diabetes: advances and challenges

3D heterogeneous islet organoid generation from human embryonic stem cells using a novel engineered hydrogel platform

(2018) Joseph Candiello et al.   BIOMATERIALS

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges

(2018) Julie B. Sneddon et al.   Cell Stem Cell

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1

(2018) Bushra Memon et al.   Stem Cell Research & Therapy

Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation

(2018) Yoshinobu Takahashi et al.   Cell Reports

Demethylation of induced pluripotent stem cells from type 1 diabetic patients enhances differentiation into functional pancreatic β cells

(2017) Gohar S. Manzar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of Islet Organoids from H9 Human Embryonic Stem Cells in Biomimetic 3D Scaffolds

(2017) Weiwei Wang et al.   STEM CELLS AND DEVELOPMENT

Engineering Concepts in Stem Cell Research

(2017) Karthikeyan Narayanan et al.   Biotechnology Journal

ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells

(2016) Eiji Yoshihara et al.   Cell Metabolism

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

(2016) Arturo J Vegas et al.   NATURE MEDICINE

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

ECM Signaling Regulates Collective Cellular Dynamics to Control Pancreas Branching Morphogenesis

(2016) Hung Ping Shih et al.   Cell Reports

Efficient generation of functional pancreatic β-cells from human induced pluripotent stem cells

(2016) Shigeharu G. Yabe et al.   Journal of Diabetes

The Importance and Clinical Relevance of Surfaces in Tissue Culture

(2016) Graham J. Hickman et al.   ACS Biomaterials-Science & Engineering

The Importance and Clinical Relevance of Surfaces in Tissue Culture

(2016) Graham J. Hickman et al.   ACS Biomaterials Science & Engineering

Engineering pancreatic tissues from stem cells towards therapy

(2016) Yoshinobu Takahashi et al.   Regenerative Therapy

Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo

(2016) Youngjin Kim et al.   Scientific Reports

Evolving insights in cell–matrix interactions: Elucidating how non-soluble properties of the extracellular niche direct stem cell fate

(2015) Nick J. Walters et al.   Acta Biomaterialia

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

(2015) Takanori Takebe et al.   Cell Stem Cell

Pancreatic Islet-Like Three-Dimensional Aggregates Derived from Human Embryonic Stem Cells Ameliorate Hyperglycemia in Streptozotocin-Induced Diabetic Mice

(2015) Joong-Hyun Shim et al.   CELL TRANSPLANTATION

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

A prevascularized subcutaneous device-less site for islet and cellular transplantation

(2015) Andrew R Pepper et al.   NATURE BIOTECHNOLOGY

Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells

(2015) Taro Toyoda et al.   Stem Cell Research

Insulin-Producing Endocrine Cells Differentiated In Vitro From Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo

(2015) Alan D. Agulnick et al.   Stem Cells Translational Medicine

Efficient Generation of NKX6-1+ Pancreatic Progenitors from Multiple Human Pluripotent Stem Cell Lines

(2015) M. Cristina Nostro et al.   Stem Cell Reports

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape

(2014) Kaitlyn Kirk et al.   Stem Cell Research

Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics

(2014) Richard K.P. Benninger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system

(2014) Hussain Md. Shahjalal et al.   Journal of Molecular Cell Biology

Small Islets Transplantation Superiority to Large Ones: Implications from Islet Microcirculation and Revascularization

(2014) Wenjuan Li et al.   Journal of Diabetes Research

The influence of matrix properties on growth and morphogenesis of human pancreatic ductal epithelial cells in 3D

(2013) Asad Raza et al.   BIOMATERIALS

Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells

(2013) Ruiyu Xie et al.   Cell Stem Cell

Designing degradable hydrogels for orthogonal control of cell microenvironments

(2013) Prathamesh M. Kharkar et al.   CHEMICAL SOCIETY REVIEWS

Gene Regulatory Networks Governing Pancreas Development

(2013) H. Efsun Arda et al.   DEVELOPMENTAL CELL

The  -Cell/EC Axis: How Do Islet Cells Talk to Each Other?

(2013) H. Peiris et al.   DIABETES

Thyroid Hormone Promotes Postnatal Rat Pancreatic  -Cell Development and Glucose-Responsive Insulin Secretion Through MAFA

(2013) C. Aguayo-Mazzucato et al.   DIABETES

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

Islet encapsulation: advances and obstacles

(2013) G. C. Weir   DIABETOLOGIA

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Initial Cell Seeding Density Influences Pancreatic Endocrine Development During in vitro Differentiation of Human Embryonic Stem Cells

(2013) Blair K. Gage et al.   PLoS One

Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells

(2013) Jennifer E. Bruin et al.   Stem Cell Research

Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo

(2013) Alireza Rezania et al.   STEM CELLS

Tumor Endothelial Cells

(2013) A. C. Dudley   Cold Spring Harbor Perspectives in Medicine

Nonviral Methods for Inducing Pluripotency to Cells

(2013) Ryan O'Doherty et al.   Biomed Research International

Integration-free Methods for Generating Induced Pluripotent Stem Cells

(2013) Yi-ye Zhou et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?

(2012) Frans Schuit et al.   DIABETES

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

A Scalable System for Production of Functional Pancreatic Progenitors from Human Embryonic Stem Cells

(2012) Thomas C. Schulz et al.   PLoS One

The generation of iPS cells using non-viral magnetic nanoparticlebased transfection

(2011) Chang Hyun Lee et al.   BIOMATERIALS

State of the Art of Clinical Islet Transplantation and Novel Protocols of Immunosuppression

(2011) A. M. James Shapiro   Current Diabetes Reports

Stage-specific signaling through TGF  family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells

(2011) M. C. Nostro et al.   DEVELOPMENT

Immunosuppressive Effects of Streptozotocin-Induced Diabetes Result in Absolute Lymphopenia and a Relative Increase of T Regulatory Cells

(2011) Y. D. Muller et al.   DIABETES

Historical Perspective: Beginnings of the  -Cell: Current Perspectives in  -Cell Development

(2011) P. A. Seymour et al.   DIABETES

INS GFP/w human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells

(2011) S. J. Micallef et al.   DIABETOLOGIA

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

(2011) C. L. Basford et al.   DIABETOLOGIA

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs

(2011) Fumiki Yanagawa et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

How viral infections enhance or prevent type 1 diabetes-from mouse to man

(2011) M. von Herrath et al.   JOURNAL OF MEDICAL VIROLOGY

Collagen gel three-dimensional matrices combined with adhesive proteins stimulate neuronal differentiation of mesenchymal stem cells

(2011) J. H. Lee et al.   Journal of the Royal Society Interface

Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cells

(2011) Xiaofang Xu et al.   MECHANISMS OF DEVELOPMENT

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells

(2011) Yuya Kunisada et al.   Stem Cell Research

Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells

(2010) Yoav Mayshar et al.   Cell Stem Cell

Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

(2010) Achia Urbach et al.   Cell Stem Cell

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Stem cell-derived islet cells for transplantation

(2010) Juan Domínguez-Bendala et al.   Current Opinion in Organ Transplantation

Induction of pluripotency by defined factors

(2010) Keisuke Okita et al.   EXPERIMENTAL CELL RESEARCH

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET

(2010) Toshiyuki Matsui et al.   NATURE

A nonviral minicircle vector for deriving human iPS cells

(2010) Fangjun Jia et al.   NATURE METHODS

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

(2010) B.-Y. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence

(2010) Qiang Feng et al.   STEM CELLS

Developing Vasculature and Stroma in Engineered Human Myocardium

(2010) Kareen L. Kreutziger et al.   TISSUE ENGINEERING PART A

Islet Transplantation in Type 1 Diabetic Patients Using Calcineurin Inhibitor-Free Immunosuppressive Protocols Based on T-Cell Adhesion or Costimulation Blockade

(2010) Andrew M. Posselt et al.   TRANSPLANTATION

Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells

(2009) Donghui Zhang et al.   CELL RESEARCH

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

(2009) Dohoon Kim et al.   Cell Stem Cell

Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures

(2009) Mark H. Chin et al.   Cell Stem Cell

Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation

(2009) John C. Stendahl et al.   CELL TRANSPLANTATION

Are stem cells a cure for diabetes?

(2009) Michael D. McCall et al.   CLINICAL SCIENCE

Type 1 Diabetes in the BB Rat: A Polygenic Disease

(2009) R. H. Wallis et al.   DIABETES

Mouse Models of Diabetic Nephropathy

(2009) F. C. Brosius et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pancreas transplantation

(2009) Steve A White et al.   LANCET

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

(2009) Knut Woltjen et al.   NATURE

Variation in the safety of induced pluripotent stem cell lines

(2009) Kyoko Miura et al.   NATURE BIOTECHNOLOGY

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

(2009) Shuibing Chen et al.   Nature Chemical Biology

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

(2009) Noemi FUSAKI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

Clone- and Gene-Specific Aberrations of Parental Imprinting in Human Induced Pluripotent Stem Cells

(2009) Marjorie Pick et al.   STEM CELLS

Adenoviral Gene Delivery Can Reprogram Human Fibroblasts to Induced Pluripotent Stem Cells

(2009) Wenbo Zhou et al.   STEM CELLS

In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells

(2008) A. Eshpeter et al.   CELL PROLIFERATION

Guidelines and Techniques for the Generation of Induced Pluripotent Stem Cells

(2008) Nimet Maherali et al.   Cell Stem Cell

Generation of Insulin-secreting Islet-like Clusters from Human Skin Fibroblasts

(2008) Keisuke Tateishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas

(2008) Yoshifumi Saisho et al.   JOURNAL OF MOLECULAR HISTOLOGY

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Marked differences in differentiation propensity among human embryonic stem cell lines

(2008) Kenji Osafune et al.   NATURE BIOTECHNOLOGY

Induced Pluripotent Stem Cells Generated Without Viral Integration

(2008) M. Stadtfeld et al.   SCIENCE

Cell–Matrix Interactions Improve β-Cell Survival and Insulin Secretion in Three-Dimensional Culture

(2008) Laney M. Weber et al.   TISSUE ENGINEERING PART A

Reconstruction of Engineered Uterine Tissues Containing Smooth Muscle Layer in Collagen/Matrigel Scaffold In Vitro

(2008) Shuang-Hong Lü et al.   TISSUE ENGINEERING PART A