A conserved arginine residue is critical for stabilizing the N2 FeS cluster in mitochondrial complex I

Respiratory complex I – Mechanistic insights and advances in structure determination

(2020) Etienne Galemou Yoga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

Charge Transfer and Chemo-Mechanical Coupling in Respiratory Complex I

(2020) Chitrak Gupta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Respiratory complex I — structure, mechanism and evolution

(2020) Kristian Parey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation

(2020) Daniel N. Grba et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The coupling mechanism of mammalian respiratory complex I

(2020) Domen Kampjut et al.   SCIENCE

Mammalian Respiratory Complex I Through the Lens of Cryo-EM

(2019) Ahmed-Noor A. Agip et al.   Annual Review of Biophysics

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics

(2019) Etienne Galemou Yoga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structures of Respiratory Supercomplex I+III2 Reveal Functional and Conformational Crosstalk

(2019) James A. Letts et al.   MOLECULAR CELL

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease

(2019) Kristian Parey et al.   Science Advances

Long-range proton-coupled electron transfer in biological energy conversion: towards mechanistic understanding of respiratory complex I

(2018) Ville R. I. Kaila   Journal of the Royal Society Interface

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

(2018) Ahmed-Noor A. Agip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps

(2018) Jose Luis Vilas et al.   STRUCTURE

Structure of the Deactive State of Mammalian Respiratory Complex I

(2018) James N. Blaza et al.   STRUCTURE

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

(2018) Ahmed-Noor A. Agip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mammalian Mitochondrial Complex I Structure and Disease-Causing Mutations

(2018) Karol Fiedorczuk et al.   TRENDS IN CELL BIOLOGY

Proteobacterial Origin of Protein Arginine Methylation and Regulation of Complex I Assembly by MidA

(2018) Umar F. Shahul Hameed et al.   Cell Reports

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

(2018) Alfredo Cabrera-Orefice et al.   Nature Communications

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Cryo-EM structure of respiratory complex I at work

(2018) Kristian Parey et al.   eLife

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

(2018) Jasenko Zivanov et al.   IUCrJ

Using Hyperfine Electron Paramagnetic Resonance Spectroscopy to Define the Proton-Coupled Electron Transfer Reaction at Fe–S Cluster N2 in Respiratory Complex I

(2017) Nolwenn Le Breton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Role of water and protein dynamics in proton pumping by respiratory complex I

(2017) Outi Haapanen et al.   Scientific Reports

Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism

(2016) Edoardo D'Imprima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Oxidation of NADH and ROS production by respiratory complex I

(2016) Andrei D. Vinogradov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I

(2016) Judy Hirst et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Small-volume potentiometric titrations: EPR investigations of Fe-S cluster N2 in mitochondrial complex I

(2016) John J. Wright et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Scipion: A software framework toward integration, reproducibility and validation in 3D electron microscopy

(2016) J.M. de la Rosa-Trevín et al.   JOURNAL OF STRUCTURAL BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system

(2015) Febin Varghese et al.   HUMAN MOLECULAR GENETICS

Effect of methylation on the side-chain pKavalue of arginine

(2015) Marina Evich et al.   PROTEIN SCIENCE

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

Alternative FeS cluster ligands: tuning redox potentials and chemistry

(2014) Daniel W Bak et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis

(2014) Olga Zurita Rendón et al.   HUMAN MOLECULAR GENETICS

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Investigating the function of [2Fe–2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

(2013) James A. Birrell et al.   BIOCHEMICAL JOURNAL

Post-translational Modifications near the Quinone Binding Site of Mammalian Complex I

(2013) Joe Carroll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NDUFAF7 Methylates Arginine 85 in the NDUFS2 Subunit of Human Complex I

(2013) Virginie F. Rhein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the entire respiratory complex I

(2013) Rozbeh Baradaran et al.   NATURE

Complex I deficiency: clinical features, biochemistry and molecular genetics

(2012) Elisa Fassone et al.   JOURNAL OF MEDICAL GENETICS

A scaffold of accessory subunits links the peripheral arm and the distal proton-pumping module of mitochondrial complex I

(2011) Heike Angerer et al.   BIOCHEMICAL JOURNAL

High efficiency transformation by electroporation of Yarrowia lipolytica

(2011) Jia-Hung Wang et al.   JOURNAL OF MICROBIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Quinone binding and reduction by respiratory complex I

(2010) Maja A. Tocilescu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The p.M292T NDUFS2 mutation causes complex I-deficient Leigh syndrome in multiple families

(2010) Helen A. L. Tuppen et al.   BRAIN

MidA is a putative methyltransferase that is required for mitochondrial complex I function

(2010) S. Carilla-Latorre et al.   JOURNAL OF CELL SCIENCE

Structural Basis for the Mechanism of Respiratory Complex I

(2009) John M. Berrisford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Exploring the inhibitor binding pocket of respiratory complex I

(2008) Uta Fendel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS