Emerging Role of Autophagy in Anti-Tumor Immunity: Implications for the Modulation of Immunotherapy Resistance

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression

(2020) Timothy Marsh et al.   DEVELOPMENTAL CELL

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells

(2020) Maria L. Lotsberg et al.   Journal of Thoracic Oncology

Autophagy induction by thiostrepton for the improvement of anticancer therapy

(2020) Oliver Kepp et al.   Autophagy

Acquired Resistance to Immune Checkpoint Inhibitors

(2020) Adam J. Schoenfeld et al.   CANCER CELL

The future of cancer immunotherapy: microenvironment-targeting combinations

(2020) Yonina R. Murciano-Goroff et al.   CELL RESEARCH

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

(2020) Sandra Buratta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Verteporfin Inhibits PD-L1 through Autophagy and the STAT1–IRF1–TRIM28 Signaling Axis, Exerting Antitumor Efficacy

(2020) Jiyong Liang et al.   Cancer Immunology Research

Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence

(2020) Raju K. Vaddepally et al.   Cancers

New insights into the pharmacological, immunological, and CAR-T-cell approaches in the treatment of hepatocellular carcinoma

(2020) Michele Dal Bo et al.   DRUG RESISTANCE UPDATES

Selective Autophagy Conceals the Enemy: Why Cytotoxic T Cells Don’t (MH)C Pancreatic Cancer

(2020) Mihaela Bozic et al.   MOLECULAR CELL

Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

(2020) Zhi-Ling Li et al.   Nature Communications

Microautophagy – distinct molecular mechanisms handle cargoes of many sizes

(2020) Sebastian Schuck   JOURNAL OF CELL SCIENCE

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

(2020) Keith A. Lawson et al.   NATURE

Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies

(2020) Elisabeth Pérez-Ruiz et al.   DRUG RESISTANCE UPDATES

Emerging Autophagy Functions Shape the Tumor Microenvironment and Play a Role in Cancer Progression - Implications for Cancer Therapy

(2020) Silvina Odete Bustos et al.   Frontiers in Oncology

A Feedback Loop Formed by ATG7/Autophagy, FOXO3a/miR-145 and PD-L1 Regulates Stem-Like Properties and Invasion in Human Bladder Cancer

(2019) Junlan Zhu et al.   Cancers

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

The relationship between autophagy and the immune system and its applications for tumor immunotherapy

(2019) Guan-Min Jiang et al.   Molecular Cancer

Autophagy inhibition enhances PD-L1 expression in gastric cancer

(2019) Xiaojuan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

(2019) Francesca Nazio et al.   CELL DEATH AND DIFFERENTIATION

Autophagy protein ATG5 regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells

(2019) Dong Sun Oh et al.   Autophagy

The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion

(2019) Yu Xia et al.   Autophagy

Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy

(2019) Ziyu Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Emerging views of mitophagy in immunity and autoimmune diseases

(2019) Ye Xu et al.   Autophagy

YY1 regulates cancer cell immune resistance by modulating PD-L1 expression

(2019) Emily Hays et al.   DRUG RESISTANCE UPDATES

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

(2019) Lindsay DeVorkin et al.   Cell Reports

In Situ Manipulation of Dendritic Cells by an Autophagy-Regulative Nanoactivator Enables Effective Cancer Immunotherapy

(2019) Yi Wang et al.   ACS Nano

Autophagy metabolically suppresses CD8+ T cell antitumor immunity

(2019) Gillian Carleton et al.   Autophagy

Immune checkpoint inhibitor combinations: Current efforts and important aspects for success

(2019) Edo Kon et al.   DRUG RESISTANCE UPDATES

5-Hydroxytryptamine1a receptors on tumour cells induce immune evasion in lung adenocarcinoma patients with depression via autophagy/pSTAT3

(2019) Yi Liu et al.   EUROPEAN JOURNAL OF CANCER

Autophagy and mitophagy in cancer metabolic remodelling

(2019) Fabio Ferro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

(2019) Philipp Kirchner et al.   PLOS BIOLOGY

Role of B1 and B2 lymphocytes in placental ischemia-induced hypertension

(2019) Connor F. Laule et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The multi-factorial nature of clinical multidrug resistance in cancer

(2019) Yehuda G. Assaraf et al.   DRUG RESISTANCE UPDATES

The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy

(2019) Marie Chollat-Namy et al.   Cell Death & Disease

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Myeloid loss of Beclin 1 promotes PD-L1hi precursor B cell lymphoma development

(2019) Peng Tan et al.   JOURNAL OF CLINICAL INVESTIGATION

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy

(2019) Meixin Chen et al.   Advanced Science

Towards the overcoming of anticancer drug resistance mediated by p53 mutations

(2019) Xin Cao et al.   DRUG RESISTANCE UPDATES

Autophagic Reliance Promotes Metabolic Reprogramming in Oncogenic KRAS-driven Tumorigenesis

(2018) H. Helen Lin et al.   Autophagy

Rocaglamide enhances NK cell-mediated killing of non-small cell lung cancer cells by inhibiting autophagy

(2018) Chao Yao et al.   Autophagy

Targeting autophagy blocks melanoma growth by bringing natural killer cells to the tumor battlefield

(2018) Muhammad Zaeem Noman et al.   Autophagy

Mechanisms of Resistance to PD-1 and PD-L1 Blockade

(2018) Theodore S. Nowicki et al.   CANCER JOURNAL

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade

(2018) Sachet A. Shukla et al.   CELL

Selective autophagy restricts IL-9 secretion from TH9 cells: relevance in cancer growth

(2018) Isis Benoit-Lizon et al.   CELL CYCLE

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

(2018) Wei Li et al.   Cell Metabolism

Endocytosis regulation by autophagy proteins in MHC restricted antigen presentation

(2018) Christian W .Keller et al.   CURRENT OPINION IN IMMUNOLOGY

Autophagy in stem cells: repair, remodelling and metabolic reprogramming

(2018) Patricia Boya et al.   DEVELOPMENT

FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity

(2018) Theresa L. Whiteside   EXPERT OPINION ON THERAPEUTIC TARGETS

Autophagy and MHC-restricted antigen presentation

(2018) Jan Valečka et al.   MOLECULAR IMMUNOLOGY

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Defining and Understanding Adaptive Resistance in Cancer Immunotherapy

(2018) Tae Kon Kim et al.   TRENDS IN IMMUNOLOGY

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms

(2018) Annan Yang et al.   Cancer Discovery

CD4 T cell autophagy is integral to memory maintenance

(2018) Diane Murera et al.   Scientific Reports

Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity

(2018) Bassam Janji et al.   Frontiers in Immunology

Cell-Intrinsic Roles for Autophagy in Modulating CD4 T Cell Functions

(2018) Elise Jacquin et al.   Frontiers in Immunology

Tumor cell-released autophagosomes (TRAP) enhance apoptosis and immunosuppressive functions of neutrophils

(2018) Rong Gao et al.   OncoImmunology

A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity

(2018) Prabhakaran Kumar et al.   JOURNAL OF AUTOIMMUNITY

Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells

(2018) Themis Alissafi et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia

(2018) Lu Ding et al.   OncoTargets and Therapy

Cytokines in clinical cancer immunotherapy

(2018) Pedro Berraondo et al.   BRITISH JOURNAL OF CANCER

Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma

(2018) Xinqun Li et al.   CELL DEATH AND DIFFERENTIATION

The multifaceted role of autophagy in cancer and the microenvironment

(2018) Hendrik Folkerts et al.   MEDICINAL RESEARCH REVIEWS

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10

(2018) Peng Tan et al.   PLOS BIOLOGY

The Role of Autophagy in iNKT Cell Development

(2018) Guan Yang et al.   Frontiers in Immunology

Systemic autophagy in the therapeutic response to anthracycline-based chemotherapy

(2018) Francesca Castoldi et al.   OncoImmunology

Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1

(2018) Zhi-Fa Wen et al.   Journal for ImmunoTherapy of Cancer

Blocking Autophagy in Cancer-Associated Fibroblasts Supports Chemotherapy of Pancreatic Cancer Cells

(2018) Xianbin Zhang et al.   Frontiers in Oncology

Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway

(2018) Kim De Veirman et al.   CANCER LETTERS

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

(2017) Hui-wen Lue et al.   GENES & DEVELOPMENT

Nivolumab Versus Docetaxel in Previously Treated Patients With Advanced Non–Small-Cell Lung Cancer: Two-Year Outcomes From Two Randomized, Open-Label, Phase III Trials (CheckMate 017 and CheckMate 057)

(2017) Leora Horn et al.   JOURNAL OF CLINICAL ONCOLOGY

A Hard(y) Look at B-1 Cell Development and Function

(2017) Nicole Baumgarth   JOURNAL OF IMMUNOLOGY

Cutting Edge: NANOG Activates Autophagy under Hypoxic Stress by Binding to BNIP3L Promoter

(2017) Meriem Hasmim et al.   JOURNAL OF IMMUNOLOGY

Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)

(2017) Jacob Schachter et al.   LANCET

Negative immune checkpoint regulation by VISTA: a mechanism of acquired resistance to anti-PD-1 therapy in metastatic melanoma patients

(2017) Hojabr Kakavand et al.   MODERN PATHOLOGY

Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1

(2017) Christina M. Maher et al.   MOLECULAR CANCER RESEARCH

Role of autophagy in MHC class I-restricted antigen presentation

(2017) Luc Van Kaer et al.   MOLECULAR IMMUNOLOGY

Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner

(2017) Takouhie Mgrditchian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging targets in cancer immunotherapy

(2017) Samantha Burugu et al.   SEMINARS IN CANCER BIOLOGY

Metabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumors

(2017) Duojiao Wu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Understanding the role of PD-L1/PD1 pathway blockade and autophagy in cancer therapy

(2017) Marianela Robainas et al.   OncoTargets and Therapy

The role of autophagy in asparaginase-induced immune suppression of macrophages

(2017) Ping Song et al.   Cell Death & Disease

Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

(2017) Thaiz Rivera Vargas et al.   Nature Communications

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

(2017) Scott Gettinger et al.   Cancer Discovery

Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer

(2017) Xuyao Zhang et al.   Cancer Immunology Research

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy

(2017) Yongbin Wang et al.   EBioMedicine

Resistance to anticancer immunity in cancer patients: potential strategies to reverse resistance

(2016) B. Bonavida et al.   ANNALS OF ONCOLOGY

Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

(2016) J. M. Pitt et al.   ANNALS OF ONCOLOGY

Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages

(2016) Jacinta P. W. Lee et al.   Autophagy

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia

(2016) S. Piya et al.   BLOOD

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

(2016) Curtis A. Clark et al.   CANCER RESEARCH

Key roles of autophagy in regulating T-cell function

(2016) Yair Botbol et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autophagy in Plasma Cell Ontogeny and Malignancy

(2016) Enrico Milan et al.   JOURNAL OF CLINICAL IMMUNOLOGY

High-mobility group box protein 1 promotes the survival of myeloid-derived suppressor cells by inducing autophagy

(2016) Katherine H. Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles)

(2016) Y Xing et al.   Cell Death & Disease

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

(2016) Shohei Koyama et al.   Nature Communications

Autophagy-associated immune responses and cancer immunotherapy

(2016) Hongming Pan et al.   Oncotarget

The multifaceted role of autophagy in tumor evasion from immune surveillance

(2016) Bassam Janji et al.   Oncotarget

Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer

(2016) R. F. Sweis et al.   Cancer Immunology Research

Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway

(2016) Meng Zhou et al.   OncoImmunology

SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL

(2015) Soo-Ho Choi et al.   Autophagy

TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy

(2015) Yu Matsuzawa et al.   Autophagy

Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1

(2015) Wei Jia et al.   Autophagy

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses

(2015) J Arnold et al.   CELL DEATH AND DIFFERENTIATION

TRAF3IP3, a novel autophagy up-regulated gene, is involved in marginal zone B lymphocyte development and survival

(2015) S. Peng et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

(2015) S. Loi et al.   CLINICAL CANCER RESEARCH

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Antibody-targeted drugs and drug resistance—Challenges and solutions

(2015) LeeRon Shefet-Carasso et al.   DRUG RESISTANCE UPDATES

The Selective Degradation of Synaptic Connexin 43 Protein by Hypoxia-induced Autophagy Impairs Natural Killer Cell-mediated Tumor Cell Killing

(2015) Andrés Tittarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells

(2015) Jichen Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Invariant NKT Cells Require Autophagy To Coordinate Proliferation and Survival Signals during Differentiation

(2015) Bo Pei et al.   JOURNAL OF IMMUNOLOGY

Atg5 but not Atg7 in dendritic cells enhances IL-2 and IFN-γ production by Toxoplasma gondii-reactive CD4+ T cells

(2015) Elizabeth Liu et al.   MICROBES AND INFECTION

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

(2015) Daniel Herranz et al.   NATURE MEDICINE

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF V600E melanoma

(2015) Siwen Hu-Lieskovan et al.   Science Translational Medicine

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy

(2015) W. Peng et al.   Cancer Discovery

Autophagy-mediated regulation of macrophages and its applications for cancer

(2014) Peiwen Chen et al.   Autophagy

Autophagy: An adaptive metabolic response to stress shaping the antitumor immunity

(2014) Elodie Viry et al.   BIOCHEMICAL PHARMACOLOGY

Autophagy in T-cell development, activation and differentiation

(2014) Alisha W Bronietzki et al.   IMMUNOLOGY AND CELL BIOLOGY

Cross-presentation of viral antigens in dribbles leads to efficient activation of virus-specific human memory t cells

(2014) Wei Ye et al.   Journal of Translational Medicine

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Autophagy is essential for effector CD8+ T cell survival and memory formation

(2014) Xiaojin Xu et al.   NATURE IMMUNOLOGY

Essential role for autophagy in the maintenance of immunological memory against influenza infection

(2014) Min Chen et al.   NATURE MEDICINE

Essential role for autophagy during invariant NKT cell development

(2014) Mariolina Salio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy is a critical regulator of memory CD8+ T cell formation

(2014) Daniel J Puleston et al.   eLife

Autophagic degradation of GZMB/granzyme B

(2013) Elodie Viry et al.   Autophagy

Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation

(2013) Chih-Peng Chang et al.   Autophagy

SnapShot: Selective Autophagy

(2013) Meiyan Jin et al.   CELL

TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance

(2013) Muhammad Baghdadi et al.   IMMUNITY

Cutting Edge: Hypoxia-Induced Nanog Favors the Intratumoral Infiltration of Regulatory T Cells and Macrophages via Direct Regulation of TGF- 1

(2013) M. Hasmim et al.   JOURNAL OF IMMUNOLOGY

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

(2013) J. Baginska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective autophagy regulates T cell activation

(2012) Suman Paul et al.   Autophagy

Hypoxia-induced autophagy

(2012) Muhammad Zaeem Noman et al.   Autophagy

Interleukin-6

(2012) Nikki A. Delk et al.   Autophagy

Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death

(2012) Isabelle Martins et al.   Autophagy

Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression

(2012) X. Liang et al.   CANCER RESEARCH

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

(2012) Claudia Capparelli et al.   CELL CYCLE

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice

(2012) C. Liu et al.   CLINICAL CANCER RESEARCH

Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice

(2012) Heng Lin et al.   HEPATOLOGY

Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis

(2012) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy-assisted antigen cross-presentation

(2012) Yongxiang Yi et al.   OncoImmunology

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

(2011) Federica Sotgia et al.   Annual Review of Pathology-Mechanisms of Disease

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

(2011) M. Z. Noman et al.   CANCER RESEARCH

Activation of autophagy in mesenchymal stem cells provides tumor stromal support

(2011) Cecilia G. Sanchez et al.   CARCINOGENESIS

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

(2011) J R Kovacs et al.   CELL DEATH AND DIFFERENTIATION

Tumor-Derived Autophagosome Vaccine: Induction of Cross-Protective Immune Responses against Short-lived Proteins through a p62-Dependent Mechanism

(2011) C. G. Twitty et al.   CLINICAL CANCER RESEARCH

Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy

(2011) W. Jia et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-Dependent Inhibition of Tumor Cell Susceptibility to CTL-Mediated Lysis Involves NANOG Induction in Target Cells

(2011) Meriem Hasmim et al.   JOURNAL OF IMMUNOLOGY

Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response

(2011) Haiyan Li et al.   Nature Nanotechnology

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Granzymes in cancer and immunity

(2010) S P Cullen et al.   CELL DEATH AND DIFFERENTIATION

Autophagy facilitates major histocompatibility complex class I expression induced by IFN-γ in B16 melanoma cells

(2009) Bo Li et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

(2009) H. H. Pua et al.   JOURNAL OF IMMUNOLOGY