A Feedback Loop Formed by ATG7/Autophagy, FOXO3a/miR-145 and PD-L1 Regulates Stem-Like Properties and Invasion in Human Bladder Cancer

CD44s is a crucial ATG7 downstream regulator for stem-like property, invasion, and lung metastasis of human bladder cancer (BC) cells

(2019) Junlan Zhu et al.   ONCOGENE

ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability

(2019) Junlan Zhu et al.   Advanced Science

EGFR activation induced Snail-dependent EMT and myc-dependent PD-L1 in human salivary adenoid cystic carcinoma cells

(2018) Yang Wang et al.   CELL CYCLE

Reciprocal Network between Cancer Stem-Like Cells and Macrophages Facilitates the Progression and Androgen Deprivation Therapy Resistance of Prostate Cancer

(2018) Hai Huang et al.   CLINICAL CANCER RESEARCH

miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a

(2018) Man-Qing Cao et al.   Journal of Hematology & Oncology

Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4–miR-18a pathway in cervical cancer

(2018) Peixin Dong et al.   ONCOGENE

PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

(2018) Jake S. O’Donnell et al.   SEMINARS IN CANCER BIOLOGY

FOXO3 Inhibits Human Gastric Adenocarcinoma (AGS) Cell Growth by Promoting Autophagy in an Acidic Microenvironment

(2018) Yuan Gao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Critical role of FOXO3a in carcinogenesis

(2018) Ying Liu et al.   Molecular Cancer

miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2

(2018) Haijian Zhang et al.   Oncology Letters

PD-L1 Expression Correlates With Tumor Infiltrating Lymphocytes And Response To Neoadjuvant Chemotherapy In Cervical Cancer

(2018) Ying Meng et al.   Journal of Cancer

Clinicopathologic Significance and Prognostic Value of Programmed Cell Death Ligand 1 (PD-L1) in Patients With Hepatocellular Carcinoma: A Meta-Analysis

(2018) Jing-Hua Li et al.   Frontiers in Immunology

Circ_0058063 regulates CDK6 to promote bladder cancer progression by sponging miR-145-5p

(2018) Ming Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

(2018) Xin Jin et al.   MOLECULAR CELL

Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma

(2018) Fang Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer

(2018) Jingyi Liu et al.   Nature Communications

A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells

(2017) Tomoaki Takai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

XB130 enhances invasion and migration of human colorectal cancer cells by promoting epithelial-mesenchymal transition

(2017) Jiancheng Shen et al.   Molecular Medicine Reports

TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer

(2017) Junlong Zhuang et al.   Theranostics

ATG7 Overexpression Is Crucial for Tumorigenic Growth of Bladder Cancer In Vitro and In Vivo by Targeting the ETS2/miRNA196b/FOXO1/p27 Axis

(2017) Junlan Zhu et al.   Molecular Therapy-Nucleic Acids

NF-κB p65 Overexpression Promotes Bladder Cancer Cell Migration via FBW7-Mediated Degradation of RhoGDIα Protein

(2017) Junlan Zhu et al.   NEOPLASIA

Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells

(2016) Haishan Huang et al.   Autophagy

SESN2/sestrin 2 induction-mediated autophagy and inhibitory effect of isorhapontigenin (ISO) on human bladder cancers

(2016) Yuguang Liang et al.   Autophagy

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34+Hematopoietic Stem-Progenitor Cells

(2016) Maria Catalina Gomez-Puerto et al.   STEM CELLS

EGFR-TKI down-regulates PD-L1 in EGFR mutant NSCLC through inhibiting NF-κB

(2015) Kailong Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

microRNA-145 promotes differentiation in human urothelial carcinoma through down-regulation of syndecan-1

(2015) Tomomi Fujii et al.   BMC CANCER

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure

(2015) H. Huang et al.   CLINICAL CANCER RESEARCH

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

PD-L1 induces epithelial-to-mesenchymal transition via activating SREBP-1c in renal cell carcinoma

(2015) Yiwei Wang et al.   MEDICAL ONCOLOGY

Isorhapontigenin suppresses growth of patient-derived glioblastoma spheres through regulating miR-145/SOX2/cyclin D1 axis

(2015) Zhou Xu et al.   NEURO-ONCOLOGY

PDL1 Regulation by p53 via miR-34

(2015) Maria Angelica Cortez et al.   JNCI-Journal of the National Cancer Institute

Crucial Role of c-Jun Phosphorylation at Ser63/73 Mediated by PHLPP Protein Degradation in the Cheliensisin A Inhibition of Cell Transformation

(2014) J. Zhu et al.   Cancer Prevention Research

MicroRNA-513 Regulates B7-H1 Translation and Is Involved in IFN- -Induced B7-H1 Expression in Cholangiocytes

(2014) A.-Y. Gong et al.   JOURNAL OF IMMUNOLOGY

FOXO3a-mediated suppression of the self-renewal capacity of sphere-forming cells derived from the ovarian cancer SKOV3 cell line by 7-difluoromethoxyl-5,4′-di-n-octyl genistein

(2014) YINGXIA NING et al.   Molecular Medicine Reports

Autophagy in stem cells

(2013) Jun-Lin Guan et al.   Autophagy

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

microRNA, Cancer and Cancer Chemoprevention

(2013) Xun Che et al.   Current Molecular Pharmacology

The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation

(2012) Isei Tanida et al.   Autophagy

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Changing patterns of bladder cancer in the USA: evidence of heterogeneous disease

(2011) Yawei Zhang et al.   BJU INTERNATIONAL

Forkhead transcription factors: key players in health and disease

(2011) Bérénice A. Benayoun et al.   TRENDS IN GENETICS

Cancer stem cells in bladder cancer: a revisited and evolving concept

(2010) Keith Syson Chan et al.   CURRENT OPINION IN UROLOGY

MicroRNA-155Regulates Cell Survival, Growth, and Chemosensitivity by TargetingFOXO3ain Breast Cancer

(2010) William Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Foxo3a Regulates Apoptosis by Negatively Targeting miR-21

(2010) Kun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Micro-RNA-145 is regulated by a highly conserved genomic sequence 3′ to the pre-miR

(2010) Gaspare La Rocca et al.   JOURNAL OF CELLULAR PHYSIOLOGY

High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation

(2010) Chuan-Yong Mu et al.   MEDICAL ONCOLOGY

TNF-α Induction by Nickel Compounds is Specific Through ERKs/AP-1- Dependent Pathway in Human Bronchial Epithelial Cells

(2009) Jin Ding et al.   CURRENT CANCER DRUG TARGETS

Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA

(2009) Min-Ju Chae et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

(2009) K. S. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Genetic Analysis of FOXO Nuclear-Cytoplasmic Shuttling by Using Image-Based Cell Screening

(2008) Fabian Zanella et al.   CHEMBIOCHEM

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

miRDB: A microRNA target prediction and functional annotation database with a wiki interface

(2008) X. Wang   RNA