Stem cell-like memory T cells: A perspective from the dark side

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

(2020) Christopher C. Nixon et al.   NATURE

Evaluation of antiviral T cell responses and TSCM cells in volunteers enrolled in a phase I HIV-1 subtype C prophylactic vaccine trial in India

(2020) Sivasankaran Munusamy Ponnan et al.   PLoS One

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

(2020) Hassen Kared et al.   Nature Communications

Memory CD4+ T Cells in Immunity and Autoimmune Diseases

(2020) Itay Raphael et al.   Cells

A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes

(2020) Stefan Emming et al.   NATURE IMMUNOLOGY

Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

(2020) Hossam A. Abdelsamed et al.   NATURE IMMUNOLOGY

Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection

(2020) Feng Hsiao et al.   PLoS Pathogens

Delivery of benzoylaconitine using biodegradable nanoparticles to suppress inflammation via regulating NF-κB signaling

(2020) Weiwei Gai et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Long noncoding RNA NKILA regulates HIV-1 replication and latency through repressing NF-ĸB signaling

(2020) Hong Wang et al.   JOURNAL OF VIROLOGY

Reckoning with mortality: global health, HIV, and the politics of data

(2020) Matthew M Kavanagh et al.   LANCET

A Novel lncRNA, AK130181, Contributes to HIV-1 Latency by Regulating Viral Promoter-Driven Gene Expression in Primary CD4+ T Cells

(2020) Haiyu Li et al.   Molecular Therapy-Nucleic Acids

Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Mitchell T Wallin et al.   LANCET NEUROLOGY

Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis

(2019) Hong-Gyun Lee et al.   Nature Communications

Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells

(2019) Zinaida Good et al.   NATURE BIOTECHNOLOGY

Effects on immune system and viral reservoir of a short-cycle antiretroviral therapy in virologically suppressed HIV+ patients

(2019) Alberto C. Guardo et al.   AIDS

Expansion of stem-cell-like CD4+ memory T cells during acute HIV-1 infection is linked to rapid disease progression

(2019) Jernej Pušnik et al.   JOURNAL OF VIROLOGY

Alternate NF-κB independent signaling re-activation of latent HIV-1 provirus

(2019) Chiara Acchioni et al.   JOURNAL OF VIROLOGY

GM-CSF and CXCR4 define a T helper cell signature in multiple sclerosis

(2019) Edoardo Galli et al.   NATURE MEDICINE

Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis

(2019) Milad Azami et al.   PLoS One

Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis

(2019) Melanie Wittner et al.   PLoS One

Brain-resident memory T cells generated early in life predispose to autoimmune disease in mice

(2019) Karin Steinbach et al.   Science Translational Medicine

Proliferative memory SAMHD1low CD4+ T cells harbour high levels of HIV-1 with compartmentalized viral populations

(2019) Lylia Hani et al.   PLoS Pathogens

Modulation of asymmetric cell division as a mechanism to boost CD8+ T cell memory

(2019) Mariana Borsa et al.   Science Immunology

Fatigue, Sleep, and Autoimmune and Related Disorders

(2019) Mark R. Zielinski et al.   Frontiers in Immunology

Pharmacological Modulation of the Wnt/β-Catenin Pathway Inhibits Proliferation and Promotes Differentiation of Long-Lived Memory CD4+ T Cells in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques

(2019) M. Mavigner et al.   JOURNAL OF VIROLOGY

Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal

(2019) Wim Trypsteen et al.   PLoS One

Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa

(2019) Jon Cantero-Pérez et al.   Nature Communications

Detection and Characterization of CD8+Autoreactive Memory Stem T Cells in Patients With Type 1 Diabetes

(2018) Debora Vignali et al.   DIABETES

Strong homeostatic TCR signals induce formation of self‐tolerant virtual memory CD8 T cells

(2018) Ales Drobek et al.   EMBO JOURNAL

Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis

(2018) Keiji Hirota et al.   IMMUNITY

Adoptive Transfer of Interleukin-21-stimulated Human CD8+ T Memory Stem Cells Efficiently Inhibits Tumor Growth

(2018) Yingshi Chen et al.   JOURNAL OF IMMUNOTHERAPY

Suppression of Tcf1 by Inflammatory Cytokines Facilitates Effector CD8 T Cell Differentiation

(2018) Maxime Danilo et al.   Cell Reports

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

(2018) Pedro Costa del Amo et al.   PLOS BIOLOGY

Role of stem cell-like memory T cells in systemic lupus erythematosus

(2018) Ye Ji Lee et al.   Arthritis & Rheumatology

Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus

(2018) Takayuki Katsuyama et al.   Frontiers in Immunology

Modulation of CD8+ memory stem T cell activity and glycogen synthase kinase 3β inhibition enhances anti-tumoral immunity in gastric cancer

(2018) Jin-yu Zhang et al.   OncoImmunology

Vitamin D in SLE: a role in pathogenesis and fatigue? A review of the literature

(2018) MH Nguyen et al.   LUPUS

IL-15 regulates susceptibility of CD4+ T cells to HIV infection

(2018) Lara Manganaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role of stem cell memory-like T cell in immune thrombocytopenia

(2018) Jiang Cao et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity

(2018) Aleksey Molodtsov et al.   Frontiers in Immunology

Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation

(2018) Yao Chen et al.   Frontiers in Immunology

Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

(2017) Hossam A. Abdelsamed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

NFκB–Pim-1–Eomesodermin axis is critical for maintaining CD8 T-cell memory quality

(2017) Karin M. Knudson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies

(2017) Frances Rees et al.   RHEUMATOLOGY

CD4+ T Memory Stem Cells Correlate with Disease Progression in Chronically HIV-1-Infected Patients

(2017) Xiaofan Lu et al.   VIRAL IMMUNOLOGY

The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+ T-cell-mediated antitumor memory immune response

(2017) Kun He et al.   Cell Death & Disease

A novel mechanism linking memory stem cells with innate immunity in protection against HIV-1 infection

(2017) Yufei Wang et al.   Scientific Reports

Rapid Recall Ability of Memory T cells is Encoded in their Epigenome

(2017) Artem Barski et al.   Scientific Reports

Memory of Inflammation in Regulatory T Cells

(2016) Joris van der Veeken et al.   CELL

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival

(2016) Rigel J. Kishton et al.   Cell Metabolism

Generating long-lived CD8+T-cell memory: Insights from epigenetic programs

(2016) Pranay Dogra et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis

(2016) Patrick Blanco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+Memory Stem Cells in Acquired Aplastic Anemia

(2016) Kohei Hosokawa et al.   JOURNAL OF IMMUNOLOGY

Antiretroviral Therapy in Simian Immunodeficiency Virus-Infected Sooty Mangabeys: Implications for AIDS Pathogenesis

(2016) Francesca Calascibetta et al.   JOURNAL OF VIROLOGY

Initiation of Antiretroviral Therapy Restores CD4+T Memory Stem Cell Homeostasis in Simian Immunodeficiency Virus-Infected Macaques

(2016) Emily K. Cartwright et al.   JOURNAL OF VIROLOGY

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes

(2016) Katherine C. Verbist et al.   NATURE

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

(2016) Kristen N Pollizzi et al.   NATURE IMMUNOLOGY

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

(2016) Lenka V. Hurton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV integration and the establishment of latency in CCL19-treated resting CD4+ T cells require activation of NF-κB

(2016) Suha Saleh et al.   Retrovirology

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic Flux

(2016) Raya Ahmed et al.   Cell Reports

CD8 + T Lymphocyte Self-Renewal during Effector Cell Determination

(2016) Wen-Hsuan W. Lin et al.   Cell Reports

Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells

(2016) Godehard Scholz et al.   EBioMedicine

T memory stem cells are the hierarchical apex of adult T-cell leukemia

(2015) Y. Nagai et al.   BLOOD

Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial

(2015) K. L. Bride et al.   BLOOD

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity

(2015) Guoliang Cui et al.   CELL

Polarization diversity of human CD4+ stem cell memory T cells

(2015) Masaru Takeshita et al.   CLINICAL IMMUNOLOGY

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Enhancement of CD8+ T-cell memory by removal of a vaccinia virus nuclear factor-κ B inhibitor

(2015) Hongwei Ren et al.   IMMUNOLOGY

Peripheral Blood–Derived Virus-Specific Memory Stem T Cells Mature to Functional Effector Memory Subsets with Self-Renewal Potency

(2015) Michael Schmueck-Henneresse et al.   JOURNAL OF IMMUNOLOGY

Prolonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like Properties

(2015) Selena Vigano et al.   JOURNAL OF VIROLOGY

CD161intCD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut

(2015) J R Fergusson et al.   Mucosal Immunology

Pathophysiology of T follicular helper cells in humans and mice

(2015) Hideki Ueno et al.   NATURE IMMUNOLOGY

Transcriptional profiles reveal a stepwise developmental program of memory CD8+ T cell differentiation

(2015) Rahul Roychoudhuri et al.   VACCINE

Low Frequency of Circulating CD8+ T Stem Cell Memory Cells in Chronic Chagasic Patients with Severe Forms of the Disease

(2015) Jose Mateus et al.   PLoS Neglected Tropical Diseases

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

(2014) Ania Skowera et al.   DIABETES

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis

(2014) Hui-fang Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell immune abnormalities in immune thrombocytopenia

(2014) Xuebin Ji et al.   Journal of Hematology & Oncology

Histone Acetylation Facilitates Rapid and Robust Memory CD8 T Cell Response through Differential Expression of Effector Molecules (Eomesodermin and Its Targets: Perforin and Granzyme B)

(2014) Y. Araki et al.   JOURNAL OF IMMUNOLOGY

Divergent CD4+ T Memory Stem Cell Dynamics in Pathogenic and Nonpathogenic Simian Immunodeficiency Virus Infections

(2014) E. K. Cartwright et al.   JOURNAL OF IMMUNOLOGY

The CD8+ Memory Stem T Cell (TSCM) Subset Is Associated with Improved Prognosis in Chronic HIV-1 Infection

(2014) S. P. Ribeiro et al.   JOURNAL OF VIROLOGY

CD4+ Memory Stem Cells Are Infected by HIV-1 in a Manner Regulated in Part by SAMHD1 Expression

(2014) C. O. Tabler et al.   JOURNAL OF VIROLOGY

Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma

(2014) Kenji Ishitsuka et al.   LANCET ONCOLOGY

HIV-1 persistence in CD4+ T cells with stem cell–like properties

(2014) Maria J Buzon et al.   NATURE MEDICINE

Systemic lupus erythematosus and lupus nephritis

(2014) Toli Koutsokeras et al.   NATURE REVIEWS DRUG DISCOVERY

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4+T-cell subsets, including stem cell memory T-cells

(2014) Kieran Cashin et al.   Retrovirology

Quantifying Susceptibility of CD4+ Stem Memory T-Cells to Infection by Laboratory Adapted and Clinical HIV-1 Strains

(2014) Jacqueline Flynn et al.   Viruses-Basel

Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4+ memory T Cells

(2014) S. Jaafoura et al.   Nature Communications

Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals

(2014) Nichole R. Klatt et al.   PLoS Pathogens

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Cell-Intrinsic Requirement for NF- B-Inducing Kinase in CD4 and CD8 T Cell Memory

(2013) A. M. Rowe et al.   JOURNAL OF IMMUNOLOGY

Enhanced CD4+ T-Cell Recovery with Earlier HIV-1 Antiretroviral Therapy

(2013) Tuan Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanistic basis of immunotherapies for type 1 diabetes mellitus

(2013) Wenhao Chen et al.   Translational Research

Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells

(2013) Amandine Legat et al.   Frontiers in Immunology

Human T Cell Lymphotropic Virus Type 1 Viral Load Variability and Long-Term Trends in Asymptomatic Carriers and in Patients with Human T Cell Lymphotropic Virus Type 1-Related Diseases

(2012) Maria A. Demontis et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors

(2012) N. Cieri et al.   BLOOD

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Autoimmunity-mediated antitumor immunity: Tumor as an immunoprivileged self

(2012) Jason Miska et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pre-morbid human T-lymphotropic virus type I proviral load, rather than percentage of abnormal lymphocytes, is associated with an increased risk of aggressive adult T-cell leukemia/lymphoma

(2012) A. Hodson et al.   HAEMATOLOGICA

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

Cutting Edge: Generation of Memory Precursors and Functional Memory CD8+ T Cells Depends on T Cell Factor-1 and Lymphoid Enhancer-Binding Factor-1

(2012) X. Zhou et al.   JOURNAL OF IMMUNOLOGY

The Increasing Onset of Type 1 Diabetes in Children

(2012) Kevin Hummel et al.   JOURNAL OF PEDIATRICS

Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

(2012) Jared H. Rowe et al.   NATURE

Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells

(2012) Enrico Lugli et al.   Nature Protocols

Population Based Study of 12 Autoimmune Diseases in Sardinia, Italy: Prevalence and Comorbidity

(2012) Claudia Sardu et al.   PLoS One

NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice

(2011) Susan E. Murray et al.   JOURNAL OF CLINICAL INVESTIGATION

Response to self antigen imprints regulatory memory in tissues

(2011) Michael D. Rosenblum et al.   NATURE

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

CD161-Expressing Human T Cells

(2011) Joannah R. Fergusson et al.   Frontiers in Immunology

The changing epidemiology of type 1 diabetes: why is it going through the roof?

(2010) Kendra Vehik et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

The changing demographic pattern of multiple sclerosis epidemiology

(2010) Nils Koch-Henriksen et al.   LANCET NEUROLOGY

Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory

(2010) G. Jeannet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Constitutive Activation of Wnt Signaling Favors Generation of Memory CD8 T Cells

(2009) D.-M. Zhao et al.   JOURNAL OF IMMUNOLOGY

Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency

(2009) A. Duverger et al.   JOURNAL OF VIROLOGY

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

(2009) A. R. Stacey et al.   JOURNAL OF VIROLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

(2009) Luca Gattinoni et al.   NATURE MEDICINE

Different T Cell Receptor Signals Determine CD8+ Memory Versus Effector Development

(2009) E. Teixeiro et al.   SCIENCE

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

(2009) Douglas C. Palmer et al.   TRENDS IN IMMUNOLOGY

A primary care back pain screening tool: Identifying patient subgroups for initial treatment

(2008) Jonathan C. Hill et al.   ARTHRITIS AND RHEUMATISM

Distinct regulation of effector and memory T-cell differentiation

(2008) Axel Kallies   IMMUNOLOGY AND CELL BIOLOGY