Pathophysiology of T follicular helper cells in humans and mice

Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy

(2014) Anthony P. West et al.   CELL

Discovery of single-gene inborn errors of immunity by next generation sequencing

(2014) Mary Ellen Conley et al.   CURRENT OPINION IN IMMUNOLOGY

Dysregulation of Circulating Follicular Helper T Cells in Nonsmall Cell Lung Cancer

(2014) Weiwei Shi et al.   DNA AND CELL BIOLOGY

Thymic TFH cells involved in the pathogenesis of myasthenia gravis with thymoma

(2014) Min Zhang et al.   EXPERIMENTAL NEUROLOGY

The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation

(2014) Yuko Yoshida et al.   IMMUNITY

Sphingosine-1-phosphate receptor 2 is critical for follicular helper T cell retention in germinal centers

(2014) Saya Moriyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PTPN22 Controls the Germinal Center by Influencing the Numbers and Activity of T Follicular Helper Cells

(2014) C. J. Maine et al.   JOURNAL OF IMMUNOLOGY

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

(2014) Xindong Liu et al.   NATURE

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

(2014) Nathalie Schmitt et al.   NATURE IMMUNOLOGY

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity

(2014) Z. Sabouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic signaling by T follicular helper cells during germinal center B cell selection

(2014) Z. Shulman et al.   SCIENCE

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Cell Distance Mapping Identifies Functional T Follicular Helper Cells in Inflamed Human Renal Tissue

(2014) V. M. Liarski et al.   Science Translational Medicine

Phenotype and functions of memory Tfh cells in human blood

(2014) Nathalie Schmitt et al.   TRENDS IN IMMUNOLOGY

Circulating follicular helper T cells in Crohn’s disease (CD) and CD-associated colorectal cancer

(2014) Zhenlong Wang et al.   TUMOR BIOLOGY

Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection

(2014) Kristin L. Boswell et al.   PLoS Pathogens

Expression of Follicular Helper T-cell Markers in Primary Cutaneous T-cell Lymphoma

(2013) Ji-Hye Park et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells

(2013) M. F. Pascutti et al.   BLOOD

A targeted mutational landscape of angioimmunoblastic T-cell lymphoma

(2013) O. Odejide et al.   BLOOD

IL-12 receptor  1 deficiency alters in vivo T follicular helper cell response in humans

(2013) N. Schmitt et al.   BLOOD

Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia

(2013) Matthew J. Ahearne et al.   BRITISH JOURNAL OF HAEMATOLOGY

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation

(2013) Katharina U. Vogel et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation

(2013) Alvin Pratama et al.   IMMUNITY

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

T-cell subsets in the germinal center

(2013) Roybel R. Ramiscal et al.   IMMUNOLOGICAL REVIEWS

Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency

(2013) Fabienne Mazerolles et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD4+ follicular helper T cell infiltration predicts breast cancer survival

(2013) Chunyan Gu-Trantien et al.   JOURNAL OF CLINICAL INVESTIGATION

Cross Talk between Follicular Th Cells and Tumor Cells in Human Follicular Lymphoma Promotes Immune Evasion in the Tumor Microenvironment

(2013) S. Rawal et al.   JOURNAL OF IMMUNOLOGY

Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis

(2013) Chuanming Luo et al.   JOURNAL OF NEUROIMMUNOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Inadequate T follicular cell help impairs B cell immunity during HIV infection

(2013) Rafael A Cubas et al.   NATURE MEDICINE

Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-Helper, Th17- and Activated B-Cells and Correlates with Progression

(2013) Jeppe Romme Christensen et al.   PLoS One

Circulating TFH Subset Distribution Is Strongly Affected in Lupus Patients with an Active Disease

(2013) Carole Le Coz et al.   PLoS One

Inhibition of Increased Circulating Tfh Cell by Anti-CD20 Monoclonal Antibody in Patients with Type 1 Diabetes

(2013) Xinyu Xu et al.   PLoS One

T Follicular Helper Cell Dynamics in Germinal Centers

(2013) Z. Shulman et al.   SCIENCE

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Association of peripheral CD4+ CXCR5+ T cells with chronic lymphocytic leukemia

(2013) Zhanshan Cha et al.   TUMOR BIOLOGY

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Role of the frequency of blood CD4+ CXCR5+ CCR6+ T cells in autoimmunity in patients with Sjögren’s syndrome

(2012) Xue-yi Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice

(2012) J. I. Ellyard et al.   BLOOD

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

(2012) C. S. Ma et al.   BLOOD

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

(2012) F. Lemonnier et al.   BLOOD

Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity

(2012) Barbara E Stranger et al.   CURRENT OPINION IN IMMUNOLOGY

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

(2012) Sau K. Lee et al.   IMMUNITY

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

(2012) Giovanni Di Zenzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Expansion of HIV-specific T follicular helper cells in chronic HIV infection

(2012) Madelene Lindqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV and T follicular helper cells: a dangerous relationship

(2012) Carola G. Vinuesa   JOURNAL OF CLINICAL INVESTIGATION

CD4 T follicular helper cell dynamics during SIV infection

(2012) Constantinos Petrovas et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinicopathologic Characteristics of Angioimmunoblastic T-Cell Lymphoma: Analysis of the International Peripheral T-Cell Lymphoma Project

(2012) Massimo Federico et al.   JOURNAL OF CLINICAL ONCOLOGY

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

(2012) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spatial Alterations between CD4+ T Follicular Helper, B, and CD8+ T Cells during Simian Immunodeficiency Virus Infection: T/B Cell Homeostasis, Activation, and Potential Mechanism for Viral Escape

(2012) J. J. Hong et al.   JOURNAL OF IMMUNOLOGY

Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

(2012) Howard J Meyerson et al.   MODERN PATHOLOGY

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

(2012) Katja Lüthje et al.   NATURE IMMUNOLOGY

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis

(2012) Rui Liu et al.   ARTHRITIS RESEARCH & THERAPY

Expression of Programmed Death-1 in Primary Cutaneous CD4-Positive Small/Medium-Sized Pleomorphic T-Cell Lymphoma, Cutaneous Pseudo-T-Cell Lymphoma, and Other Types of Cutaneous T-Cell Lymphoma

(2011) Fatma Çetinözman et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

SLAM Family Receptors and SAP Adaptors in Immunity

(2011) Jennifer L. Cannons et al.   Annual Review of Immunology

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model

(2011) H. Martini et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells

(2011) D. G. Silva et al.   DIABETES

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition

(2011) Shingo Nakayamada et al.   IMMUNITY

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

(2011) Helen M. McGuire et al.   IMMUNITY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

(2011) Masahiro Kitano et al.   IMMUNITY

Increased Frequency of Follicular Helper T Cells in Patients with Autoimmune Thyroid Disease

(2011) Chenlu Zhu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

(2011) Sau K. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses

(2011) N. Chevalier et al.   JOURNAL OF IMMUNOLOGY

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

(2011) I. Wollenberg et al.   JOURNAL OF IMMUNOLOGY

Characterization of intratumoral follicular helper T cells in follicular lymphoma: role in the survival of malignant B cells

(2011) P Amé-Thomas et al.   LEUKEMIA

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

IRF8Mutations and Human Dendritic-Cell Immunodeficiency

(2011) Sophie Hambleton et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers

(2011) S.-E. Bentebibel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

(2011) J. A. Harker et al.   SCIENCE

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

(2010) Hsin-Jung Wu et al.   IMMUNITY

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular lymphoma cell niche: identification of a preeminent IL-4-dependent TFH–B cell axis

(2010) C Pangault et al.   LEUKEMIA

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

(2009) Nicholas Simpson et al.   ARTHRITIS AND RHEUMATISM

The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation

(2009) P. Farinha et al.   BLOOD

Advances in the understanding and management of angioimmunoblastic T-cell lymphoma

(2009) Laurence de Leval et al.   BRITISH JOURNAL OF HAEMATOLOGY

Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

(2009) Michelle A. Linterman et al.   IMMUNITY

Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12

(2009) Nathalie Schmitt et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH ) cell lineage is induced by IL-12

(2009) Cindy S Ma et al.   IMMUNOLOGY AND CELL BIOLOGY

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

(2009) J. A. Bubier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Primary Cutaneous CD4+ Small/Medium-sized Pleomorphic T-cell Lymphoma Expresses Follicular T-cell Markers

(2008) Socorro Maria Rodríguez Pinilla et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

(2008) Eynav Klechevsky et al.   IMMUNITY

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development and characterization of IL-21–producing CD4+T cells

(2008) Akira Suto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of the Follicular Dendritic Cell Reservoir of Human Immunodeficiency Virus Type 1

(2008) B. F. Keele et al.   JOURNAL OF VIROLOGY

Prolyl 4-hydroxylation regulates Argonaute 2 stability

(2008) Hank H. Qi et al.   NATURE

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE