Non-coding RNA derived from extracellular vesicles in cancer immune escape: Biological functions and potential clinical applications

Noncoding RNAs in cancer immunity: functions, regulatory mechanisms, and clinical application

(2020) Le Zhang et al.   Molecular Cancer

Peripheral T cell expansion predicts tumour infiltration and clinical response

(2020) Thomas D. Wu et al.   NATURE

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Correlation of plasma exosomal microRNAs with the efficacy of immunotherapy in EGFR/ALK wild-type advanced non-small cell lung cancer

(2020) Xiao-Xiao Peng et al.   Journal for ImmunoTherapy of Cancer

Tumor-Associated Macrophages: Recent Insights and Therapies

(2020) Jiawei Zhou et al.   Frontiers in Oncology

Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression

(2020) Wei Chen et al.   CANCER LETTERS

The Exosome Encapsulated microRNAs as Circulating Diagnostic Marker for Hepatocellular Carcinoma with Low Alpha fetoprotein

(2020) Suchandrima Ghosh et al.   INTERNATIONAL JOURNAL OF CANCER

The role of cancer-derived microRNAs in cancer immune escape

(2020) Ming Yi et al.   Journal of Hematology & Oncology

Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance

(2020) Li Yuan et al.   Molecular Cancer

Deciphering human macrophage development at single-cell resolution

(2020) Zhilei Bian et al.   NATURE

Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer

(2020) Mengmeng Jiang et al.   ONCOGENE

Modulating Cytokine Production via Select Packaging and Secretion From Extracellular Vesicles

(2020) Betsy J. Barnes et al.   Frontiers in Immunology

The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target

(2020) V. Gambardella et al.   CANCER TREATMENT REVIEWS

Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies

(2020) Xueqiang Peng et al.   Cell Communication and Signaling

Transcriptional Networks Driving Dendritic Cell Differentiation and Function

(2020) Stephen L. Nutt et al.   IMMUNITY

Circulating MicroRNAs and Extracellular Vesicle–Containing MicroRNAs as Response Biomarkers of Anti–programmed Cell Death Protein 1 or Programmed Death-Ligand 1 Therapy in NSCLC

(2020) Takehito Shukuya et al.   Journal of Thoracic Oncology

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

(2020) Peng-Fei Zhang et al.   Molecular Cancer

Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-β1 axis

(2020) Anquan Shang et al.   Molecular Cancer

CircRNAs: biogenesis, functions, and role in drug-resistant Tumours

(2020) Shuo Ma et al.   Molecular Cancer

Natural killer cells in cancer biology and therapy

(2020) Song-Yang Wu et al.   Molecular Cancer

Antitumour dendritic cell vaccination in a priming and boosting approach

(2020) Alexandre Harari et al.   NATURE REVIEWS DRUG DISCOVERY

Elevated serum YKL-40, IL-6, CRP, CEA, and CA19-9 combined as a prognostic biomarker panel after resection of colorectal liver metastases

(2020) Reetta Peltonen et al.   PLoS One

Role of MSC in the Tumor Microenvironment

(2020) Ralf Hass   Cancers

The RNA binding protein FMR1 controls selective exosomal miRNA cargo loading during inflammation

(2020) Ann L. Wozniak et al.   JOURNAL OF CELL BIOLOGY

Immune suppressed tumor microenvironment by exosomes derived from gastric cancer cells via modulating immune functions

(2020) Juan Liu et al.   Scientific Reports

Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells

(2020) Scott A. Hinger et al.   Scientific Reports

Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles

(2020) Yoichiro Harada et al.   Cell Reports

IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells

(2020) Xueqiang Peng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of exosomal noncoding RNAs in cancer

(2019) Yan Xie et al.   Molecular Cancer

Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFκB/c-Myc signaling in female esophageal carcinoma

(2019) Wei Li et al.   Molecular Cancer

Glycosylation of ascites-derived exosomal CD133: a potential prognostic biomarker in patients with advanced pancreatic cancer

(2019) Takahiko Sakaue et al.   Medical Molecular Morphology

OSCC-derived exosomes promote M2-type macrophage polarization mediated by exosome-enclosed miR-29a-3p

(2019) Jinghua Cai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

HDAC6 Suppresses Let‐7i‐5p to Elicit TSP1/CD47‐mediated Anti‐tumorigenesis and Phagocytosis of Hepatocellular Carcinoma

(2019) Hee Doo Yang et al.   HEPATOLOGY

RAB27B‐activated secretion of stem‐like tumor exosomes delivers the biomarker microRNA‐146a‐5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer

(2019) Wei‐Chung Cheng et al.   INTERNATIONAL JOURNAL OF CANCER

Mechanisms associated with biogenesis of exosomes in cancer

(2019) Kathleen M. McAndrews et al.   Molecular Cancer

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD ‐1 high Breg cells

(2019) Yu Mao et al.   CANCER SCIENCE

TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma

(2019) Xiaochen Wang et al.   JOURNAL OF HEPATOLOGY

Balancing cancer immunotherapy and immune-related adverse events: The emerging role of regulatory T cells

(2019) T. Alissafi et al.   JOURNAL OF AUTOIMMUNITY

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

(2019) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

(2019) Lichun Ma et al.   CANCER CELL

LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization

(2019) Zhen-xing Liang et al.   Cell Death & Disease

Circular RNA CDR1-AS contributes to pemetrexed and cisplatin chemoresistance through EGFR/PI3K signaling pathway in lung adenocarcinoma

(2019) Yuqiang Mao et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma

(2018) Hiroshi Higuchi et al.   BLOOD

Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion

(2018) Lin Liu et al.   Cancer Biomarkers

The emerging role of exosome-derived non-coding RNAs in cancer biology

(2018) Qing Fan et al.   CANCER LETTERS

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

(2018) Xiaofeng Wang et al.   CANCER RESEARCH

Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

(2018) Fei Xing et al.   CANCER RESEARCH

Functional Classification and Experimental Dissection of Long Noncoding RNAs

(2018) Florian Kopp et al.   CELL

Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN

(2018) Ya-Ling Hsu et al.   MOLECULAR THERAPY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC

(2018) Jie Ji et al.   Cell Death & Disease

The Potential Biomarkers and Immunological Effects of Tumor-Derived Exosomes in Lung Cancer

(2018) Shamila D. Alipoor et al.   Frontiers in Immunology

Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis

(2018) Yingkuan Shao et al.   CARCINOGENESIS

Regulation of Macrophage Activation and Polarization by HCC-Derived Exosomal lncRNA TUC339

(2018) Xue Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

(2018) Pascale André et al.   CELL

Arrested Developments: CDK4/6 Inhibitor Resistance and Alterations in the Tumor Immune Microenvironment

(2018) Jessica L.F. Teh et al.   CLINICAL CANCER RESEARCH

microRNA modified tumor-derived exosomes as novel tools for maturation of dendritic cells

(2018) Adeleh Taghikhani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

miRBase: from microRNA sequences to function

(2018) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Dendritic Cell Maturation and Function

(2018) Monica Reis et al.   Frontiers in Immunology

Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

(2017) Michael L. Merchant et al.   Nature Reviews Nephrology

Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization

(2017) Xin Chen et al.   ONCOLOGY REPORTS

Biological Functions and Current Advances in Isolation and Detection Strategies for Exosome Nanovesicles

(2017) Kseniia Boriachek et al.   Small

Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer

(2017) Yuki Takano et al.   Oncotarget

How do lncRNAs regulate transcription?

(2017) Yicheng Long et al.   Science Advances

Extracellular vesicles released by CD40/IL-4-stimulated CLL cells confer altered functional properties to CD4+ T cells

(2016) D. T. Smallwood et al.   BLOOD

Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

(2016) Le Qu et al.   CANCER CELL

Memory of Inflammation in Regulatory T Cells

(2016) Joris van der Veeken et al.   CELL

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Combination wt-p53 and MicroRNA-125b Transfection in a Genetically Engineered Lung Cancer Model Using Dual CD44/EGFR-targeting Nanoparticles

(2016) Meghna Talekar et al.   MOLECULAR THERAPY

Immunometabolism of regulatory T cells

(2016) Ryan Newton et al.   NATURE IMMUNOLOGY

The biogenesis and emerging roles of circular RNAs

(2016) Ling-Ling Chen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems

(2016) Mei-Ju Su et al.   Scientific Reports

Modification of tumor cell exosome content by transfection with wt-p53 and microRNA-125b expressing plasmid DNA and its effect on macrophage polarization

(2016) M Trivedi et al.   Oncogenesis

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

The mitochondrial lncRNA ASncmtRNA-2 is induced in aging and replicative senescence in Endothelial Cells

(2015) Valentina Bianchessi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Exon Skipping Is Correlated with Exon Circularization

(2015) Steven Kelly et al.   JOURNAL OF MOLECULAR BIOLOGY

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

(2015) Kristan E. van der Vos et al.   NEURO-ONCOLOGY

Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

(2015) Yehoshua Enuka et al.   NUCLEIC ACIDS RESEARCH

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion

(2015) Alanna E. Sedgwick et al.   Scientific Reports

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer

(2015) Guy Berchem et al.   OncoImmunology

Tumor-induced CD14+HLA-DR−/low myeloid-derived suppressor cells correlate with tumor progression and outcome of therapy in multiple myeloma patients

(2014) Zhitao Wang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NK cells gain higher IFN-γ competence during terminal differentiation

(2014) Merlin Luetke-Eversloh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage Polarization in Inflammatory Diseases

(2014) Yan-Cun Liu et al.   International Journal of Biological Sciences

Rôle des longs ARN non codants dans le développement normal et pathologique

(2014) Ève-Lyne Mathieu et al.   M S-MEDECINE SCIENCES

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers

(2014) M. Li et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer

(2014) Qier Li et al.   TUMOR BIOLOGY

Cancer Vaccines in the World of Immune Suppressive Monocytes (CD14+HLA-DRlo/neg Cells): The Gateway to Improved Responses

(2014) Rebecca R. Laborde et al.   Frontiers in Immunology

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

The Long and Short of MicroRNA

(2013) Luke A. Yates et al.   CELL

T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

(2013) Joel Crespo et al.   CURRENT OPINION IN IMMUNOLOGY

A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system

(2013) Iain Comerford et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Endogenous miRNA Sponge lincRNA-RoR Regulates Oct4, Nanog, and Sox2 in Human Embryonic Stem Cell Self-Renewal

(2013) Yue Wang et al.   DEVELOPMENTAL CELL

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion

(2013) Sabrina Schlienger et al.   MOLECULAR BIOLOGY OF THE CELL

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes

(2012) Hee Doo Lee et al.   FASEB JOURNAL

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

Immune-related MicroRNAs are Abundant in Breast Milk Exosomes

(2012) Qi Zhou et al.   International Journal of Biological Sciences

Exosome removal as a therapeutic adjuvant in cancer

(2012) Annette M Marleau et al.   Journal of Translational Medicine

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

Rho GTPases and their roles in cancer metabolism

(2012) Kristin F. Wilson et al.   TRENDS IN MOLECULAR MEDICINE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

(2011) S. A. Rosenberg et al.   CLINICAL CANCER RESEARCH

Obstacles and opportunities for understanding macrophage polarization

(2011) P. J. Murray et al.   JOURNAL OF LEUKOCYTE BIOLOGY

lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements

(2011) Chenguang Gong et al.   NATURE

Cancer-related inflammation: Common themes and therapeutic opportunities

(2011) Frances R. Balkwill et al.   SEMINARS IN CANCER BIOLOGY

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B

(2010) Ying Ju et al.   JOURNAL OF HEPATOLOGY

Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma

(2010) Sarah Beseme Nambotin et al.   JOURNAL OF HEPATOLOGY

Activation of Macrophages by P2X7-Induced Microvesicles from Myeloid Cells Is Mediated by Phospholipids and Is Partially Dependent on TLR4

(2010) L. M. Thomas et al.   JOURNAL OF IMMUNOLOGY

CD20+ B Cells: The Other Tumor-Infiltrating Lymphocytes

(2010) B. H. Nelson   JOURNAL OF IMMUNOLOGY

CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer

(2010) Jiayi Wang et al.   NUCLEIC ACIDS RESEARCH

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

(2009) Claudio Marcelo Fader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

Acid sphingomyelinase activity triggers microparticle release from glial cells

(2009) Fabio Bianco et al.   EMBO JOURNAL

The enterocyte microvillus is a vesicle-generating organelle

(2009) Russell E. McConnell et al.   JOURNAL OF CELL BIOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

(2008) Khalid Al-Nedawi et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE