IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells

The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection

(2020) Jumpei Omi et al.   Nature Communications

YAP1 inhibition in HUVECs is associated with released exosomes and increased hepatocarcinoma invasion and metastasis

(2020) Yan Li et al.   Molecular Therapy-Nucleic Acids

Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies

(2020) Xueqiang Peng et al.   Cell Communication and Signaling

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

Mechanical Stress-Dependent Autophagy Component Release via Extracellular Nanovesicles in Tumor Cells

(2019) Kaizhe Wang et al.   ACS Nano

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity

(2019) Arash Latifkar et al.   DEVELOPMENTAL CELL

Dysregulated autophagy and lysosome function are linked to exosome production via miR‐155 in alcoholic liver disease

(2019) Mrigya Babuta et al.   HEPATOLOGY

Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma

(2019) Liang Yang et al.   Molecular Cancer

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

(2019) Lin Song et al.   Nature Communications

LRP6 regulates Rab7‐mediated autophagy through the Wnt/β‐catenin pathway to modulate trophoblast cell migration and invasion

(2019) Lei Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

(2018) Georgia Minakaki et al.   Autophagy

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

(2018) Elisabet Barbero-Camps et al.   Autophagy

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100Novelty and Significance

(2018) Jaume Amengual et al.   CIRCULATION RESEARCH

Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system

(2018) Shan-Ying Wu et al.   HEPATOLOGY

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

(2018) Frederik Johannes Verweij et al.   JOURNAL OF CELL BIOLOGY

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

(2018) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting IκappaB kinases for cancer therapy

(2018) Nikee Awasthee et al.   SEMINARS IN CANCER BIOLOGY

ESCRT and autophagies: Endosomal functions and beyond

(2018) Christophe Lefebvre et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Combination Therapies Targeting HDAC and IKK in Solid Tumors

(2018) Ivana Vancurova et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

(2018) James Monypenny et al.   Cell Reports

The interplay between exosomes and autophagy – partners in crime

(2018) Jing Xu et al.   JOURNAL OF CELL SCIENCE

Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy

(2018) Margherita Leonardi et al.   Autophagy

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

Phosphorylation of SNAP-23 regulates its dynamic membrane association during mast cell exocytosis

(2017) Pieu Naskar et al.   Biology Open

Exophagy of annexin A2 via RAB11, RAB8A and RAB27A in IFN-γ-stimulated lung epithelial cells

(2017) Ying-Da Chen et al.   Scientific Reports

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

Selective endosomal microautophagy is starvation-inducible in Drosophila

(2016) Anindita Mukherjee et al.   Autophagy

PIKfyve inhibition increases exosome release and induces secretory autophagy

(2016) Nina Pettersen Hessvik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

Autophagy is essential for ultrafine particle-induced inflammation and mucus hyperproduction in airway epithelium

(2015) Zhi-Hua Chen et al.   Autophagy

RAL-1 controls multivesicular body biogenesis and exosome secretion

(2015) Vincent Hyenne et al.   JOURNAL OF CELL BIOLOGY

The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation

(2015) Martin Müller et al.   eLife

I B kinase phosphorylation of SNAP-23 controls platelet secretion

(2013) Z. A. Karim et al.   BLOOD

Tethering the assembly of SNARE complexes

(2013) WanJin Hong et al.   TRENDS IN CELL BIOLOGY

Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease

(2013) Sovan Sarkar et al.   Cell Reports

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

PKC-dependent inhibition of CA2+-dependent exocytosis from astrocytes

(2010) Keiichi Yasuda et al.   GLIA

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY