Inspired Epigenetic Modulation Synergy with Adenosine Inhibition Elicits Pyroptosis and Potentiates Cancer Immunotherapy

ATP-P2X7–Induced Inflammasome Activation Contributes to Melanocyte Death and CD8+ T-Cell Trafficking to the Skin in Vitiligo

(2020) Yuri Ahn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

(2020) Zhihao Lu et al.   NATURE

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells

(2020) Erich H. Schneider et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Prodrug‐Based Versatile Nanomedicine for Enhancing Cancer Immunotherapy by Increasing Immunogenic Cell Death

(2020) Shuang Bai et al.   Small

The adenosine pathway in immuno-oncology

(2020) Bertrand Allard et al.   Nature Reviews Clinical Oncology

Implantable Bioresponsive Nanoarray Enhances Postsurgical Immunotherapy by Activating Pyroptosis and Remodeling Tumor Microenvironment

(2020) Hongjuan Zhao et al.   ADVANCED FUNCTIONAL MATERIALS

Tumor‐Activated Size‐Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti‐Tumor Immune Responses

(2020) Jie Li et al.   ADVANCED MATERIALS

Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Atezolizumab for First-Line Treatment of PD-L1–Selected Patients with NSCLC

(2020) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engineering Prodrug Nanomedicine for Cancer Immunotherapy

(2020) Bin Yang et al.   Advanced Science

Bioresponsive prodrug nanogel-based polycondensate strategy deepens tumor penetration and potentiates oxidative stress

(2020) Xianbin Ma et al.   CHEMICAL ENGINEERING JOURNAL

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

(2019) Huitong Ruan et al.   ADVANCED MATERIALS

An Acidic-Microenvironment-Driven DNA Nanomachine Enables Specific ATP Imaging in the Extracellular Milieu of Tumor

(2019) Zhenghan Di et al.   ADVANCED MATERIALS

Extracellular ATP activates P2X7R-NF-κB (p65) pathway to promote the maturation of bone marrow-derived dendritic cells of mice

(2019) Ying Yu et al.   CYTOKINE

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

(2019) Humayun Sharif et al.   NATURE

The emerging role of epigenetic therapeutics in immuno-oncology

(2019) Michael J. Topper et al.   Nature Reviews Clinical Oncology

Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise

(2019) Daphné Morel et al.   Nature Reviews Clinical Oncology

Dendritic cell upregulation of programmed death ligand-1 via DNA demethylation inhibits experimental autoimmune encephalomyelitis

(2019) Chia-Bin Chang et al.   JOURNAL OF AUTOIMMUNITY

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

(2019) Liping Huang et al.   Nature Communications

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity

(2019) Xian-Yang Li et al.   Cancer Discovery

GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis

(2019) Jingyun Luan et al.   BIOMATERIALS

γ-Oryzanol suppresses cell apoptosis by inhibiting reactive oxygen species-mediated mitochondrial signaling pathway in H2O2-stimulated L02 cells

(2019) Lin Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Pseudoneutrophil Cytokine Sponges Disrupt Myeloid Expansion and Tumor Trafficking to Improve Cancer Immunotherapy

(2019) Shuya Li et al.   NANO LETTERS

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

(2019) Dan A. Erkes et al.   Cancer Discovery

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression

(2018) Heng Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown rice-specific γ-oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity disease in humans

(2018) Hiroaki Masuzaki et al.   Journal of Diabetes Investigation

Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation

(2018) Kristin Freudenberg et al.   Frontiers in Immunology

Recent Progresses in Phototherapy-Synergized Cancer Immunotherapy

(2018) Chee Wee Ng et al.   ADVANCED FUNCTIONAL MATERIALS

Toward Biomaterials for Enhancing Immune Checkpoint Blockade Therapy

(2018) Qin Fan et al.   ADVANCED FUNCTIONAL MATERIALS

Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis

(2018) Xuyao Zhang et al.   Nanoscale

Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy

(2018) Sara Musetti et al.   ACS Nano

PD-L1 methylation regulates PD-L1 expression and is associated with melanoma survival

(2018) Goran Micevic et al.   Pigment Cell & Melanoma Research

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma

(2017) Si-Rui Ma et al.   Molecular Cancer

Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden

(2017) Meredith L. Stone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Microenvironment-Enabled Nanotherapy

(2017) Liying Wang et al.   Advanced Healthcare Materials

Hypolipidemic mechanism of oryzanol components- ferulic acid and phytosterols

(2016) G. Bhaskaragoud et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PD1 and PDL1 upregulation and survival after decitabine treatment in lower risk MDS

(2016) Sameem Abedin et al.   LEUKEMIA & LYMPHOMA

Take two: Combining immunotherapy with epigenetic drugs to tackle cancer

(2016) Karen Weintraub   NATURE MEDICINE

Epigenetic Modulators and the New Immunotherapies

(2016) Anthony E. Dear   NEW ENGLAND JOURNAL OF MEDICINE

Role of Epigenetic Modification and Immunomodulation in a Murine Prostate Cancer Model

(2016) Jay E. Sulek et al.   PROSTATE

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape

(2016) Itsaso Montalbán del Barrio et al.   Journal for ImmunoTherapy of Cancer

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

Adenosine pathway and cancer: where do we go from here?

(2014) Luca Antonioli et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance

(2014) Yanping Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

(2014) Xiaosong Yang et al.   MOLECULAR ENDOCRINOLOGY

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

(2014) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared with their peripheral counterparts

(2013) Sarah K. Maenhout et al.   INTERNATIONAL JOURNAL OF CANCER

Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents

(2013) H Yang et al.   LEUKEMIA

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity

(2012) H Wang et al.   BRITISH JOURNAL OF CANCER

CD73: a potent suppressor of antitumor immune responses

(2012) Paul. A. Beavis et al.   TRENDS IN IMMUNOLOGY

CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice

(2011) Long Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

(2011) Christine Moussion et al.   NATURE

Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells

(2011) Dilan Dissanayake et al.   NATURE MEDICINE

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

(2009) M. Mandapathil et al.   CLINICAL CANCER RESEARCH

Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice

(2008) M S Islam et al.   BRITISH JOURNAL OF PHARMACOLOGY