An Acidic-Microenvironment-Driven DNA Nanomachine Enables Specific ATP Imaging in the Extracellular Milieu of Tumor

Engineering of Bioinspired, Size-Controllable, Self-Degradable Cancer-Targeting DNA Nanoflowers via the Incorporation of an Artificial Sandwich Base

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Near-Infrared Afterglow Semiconducting Nano-Polycomplexes for the Multiplex Differentiation of Cancer Exosomes

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Cancer Cell Membrane Camouflaged Nanoprobe for Catalytic Ratiometric Photoacoustic Imaging of MicroRNA in Living Mice

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Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells

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A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

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A pH-correctable, DNA-based fluorescent reporter for organellar calcium

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The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

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DNA Aptamer-Based Activatable Probes for Photoacoustic Imaging in Living Mice

(2017) Jingjing Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA probes for monitoring dynamic and transient molecular encounters on live cell membranes

(2017) Mingxu You et al.   Nature Nanotechnology

H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

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A microRNA-initiated DNAzyme motor operating in living cells

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Ultrasensitive tumour-penetrating nanosensors of protease activity

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Successively activatable ultrasensitive probe for imaging tumour acidity and hypoxia

(2017) Xianchuang Zheng et al.   Nature Biomedical Engineering

A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy

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Extracellular purines, purinergic receptors and tumor growth

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A Multisite-Binding Switchable Fluorescent Probe for Monitoring Mitochondrial ATP Level Fluctuation in Live Cells

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Extracellular Metabolic Energetics Can Promote Cancer Progression

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A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells

(2015) Sonali Saha et al.   Nature Nanotechnology

DNA nanotechnology from the test tube to the cell

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Universal computing by DNA origami robots in a living animal

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ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment

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ATP-triggered anticancer drug delivery

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Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

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Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics

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Organelle-Localizable Fluorescent Chemosensors for Site-Specific Multicolor Imaging of Nucleoside Polyphosphate Dynamics in Living Cells

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A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

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Cell-surface sensors for real-time probing of cellular environments

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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

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pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents

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Functional Nucleic Acid Sensors

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A DNA nanomachine that maps spatial and temporal pH changes inside living cells

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Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

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