Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
Authors
Keywords
-
Journal
Life-Basel
Volume 10, Issue 12, Pages 333
Publisher
MDPI AG
Online
2020-12-09
DOI
10.3390/life10120333
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial
- (2020) Jeremy Chataway et al. LANCET NEUROLOGY
- A Guide to Targeting the Endocannabinoid System in Drug Design
- (2020) Adam Stasiulewicz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis
- (2020) Chiara Arena et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The Role of NMDA Receptors in Alzheimer’s Disease
- (2019) Jinping Liu et al. Frontiers in Neuroscience
- The protective effects of β-caryophyllene on LPS-induced primary microglia M1/M2 imbalance: A mechanistic evaluation
- (2019) Vahid Reza Askari et al. LIFE SCIENCES
- Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
- (2019) Henriette Haukedal et al. JOURNAL OF MOLECULAR BIOLOGY
- Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington's disease in the R6/2 mouse model
- (2019) Robert B. Laprairie et al. NEUROPHARMACOLOGY
- Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery
- (2019) Francesca Gado et al. Future Medicinal Chemistry
- Cannabinoids and the expanded endocannabinoid system in neurological disorders
- (2019) Luigia Cristino et al. Nature Reviews Neurology
- Exosomes From Astrocyte Processes: Signaling to Neurons
- (2019) Arianna Venturini et al. Frontiers in Pharmacology
- An overview of the cannabinoid type 2 receptor system and its therapeutic potential
- (2018) Bihua Bie et al. Current Opinion in Anesthesiology
- Allosteric modulators of cannabinoid receptor 1: developing compounds for improved specificity
- (2018) Rachel Dopart et al. DRUG METABOLISM REVIEWS
- Near infrared laser photons induce glutamate release from cerebrocortical nerve terminals
- (2018) Andrea Amaroli et al. Journal of Biophotonics
- Identification of the first synthetic allosteric modulator of the CB2 receptors and evidence of its efficacy for neuropathic pain relief
- (2018) Francesca Gado et al. JOURNAL OF MEDICINAL CHEMISTRY
- Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences
- (2018) Daniele Bano et al. NEUROSCIENCE LETTERS
- New approaches and challenges to targeting the endocannabinoid system
- (2018) Vincenzo Di Marzo NATURE REVIEWS DRUG DISCOVERY
- Microglia in Alzheimer’s disease
- (2017) David V. Hansen et al. JOURNAL OF CELL BIOLOGY
- Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia
- (2017) Deepti Lall et al. JOURNAL OF CLINICAL INVESTIGATION
- The In Vivo Effects of the CB1-Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice
- (2017) Elizabeth A. Cairns et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders
- (2017) Daniel J. Foster et al. NEURON
- Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target
- (2017) Tommaso Cassano et al. Frontiers in Neuroscience
- Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges
- (2017) Attila Oláh et al. Frontiers in Immunology
- Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence
- (2017) Richard A. Slivicki et al. BIOLOGICAL PSYCHIATRY
- Cannabinoid receptor-2 stimulation suppresses neuroinflammation by regulating microglial M1/M2 polarization through the cAMP/PKA pathway in an experimental GMH rat model
- (2016) Yihao Tao et al. BRAIN BEHAVIOR AND IMMUNITY
- A2A-D2 receptor-receptor interaction modulates gliotransmitter release from striatal astrocyte processes
- (2016) Chiara Cervetto et al. JOURNAL OF NEUROCHEMISTRY
- Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities
- (2016) Richard Macrez et al. LANCET NEUROLOGY
- Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor
- (2016) Thuy Nguyen et al. MEDICINAL RESEARCH REVIEWS
- Inflammation, Glutamate and Glia: A Trio of Trouble in Mood Disorders
- (2016) Ebrahim Haroon et al. NEUROPSYCHOPHARMACOLOGY
- Microglia activation states and cannabinoid system: Therapeutic implications
- (2016) M. Mecha et al. PHARMACOLOGY & THERAPEUTICS
- 4-Аminopyridine sequesters intracellular Ca2+ which triggers exocytosis in excitable and non-excitable cells
- (2016) Ludmila A. Kasatkina Scientific Reports
- Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling
- (2015) Lei Ma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Microglial M1/M2 polarization and metabolic states
- (2015) Ruben Orihuela et al. BRITISH JOURNAL OF PHARMACOLOGY
- Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
- (2015) Yu Tang et al. MOLECULAR NEUROBIOLOGY
- Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse
- (2015) Chiara Cervetto et al. NEUROMOLECULAR MEDICINE
- Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes
- (2015) Chiara Cervetto et al. NEUROPHARMACOLOGY
- Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1
- (2015) Lorenzo Di Cesare Mannelli et al. NEUROPHARMACOLOGY
- Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex
- (2015) Monica Averna et al. PLoS One
- Involvement of β-arrestin-2 and Clathrin in Agonist-Mediated Internalization of the Human Cannabinoid CB2 Receptor
- (2015) Xiaopan Chen et al. Current Molecular Pharmacology
- Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis
- (2014) Alessandra Musella et al. NEUROPHARMACOLOGY
- COX-2-derived endocannabinoid metabolites as novel inflammatory mediators
- (2014) Mireille Alhouayek et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro
- (2013) Emelie Janefjord et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
- (2012) Javier Fernández-Ruiz et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice
- (2012) Ana María Martín-Moreno et al. Journal of Neuroinflammation
- Potentiation of NMDA Receptor-Dependent Cell Responses by Extracellular High Mobility Group Box 1 Protein
- (2012) Marco Pedrazzi et al. PLoS One
- Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway
- (2011) Natasha L. Grimsey et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Endocannabinoid content in fetal bovine sera — Unexpected effects on mononuclear cells and osteoclastogenesis
- (2011) Janine Marazzi et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease
- (2011) A. M. Martin-Moreno et al. MOLECULAR PHARMACOLOGY
- Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration
- (2010) Joanna Mikita et al. Multiple Sclerosis Journal
- Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
- (2010) Joel E Schlosburg et al. NATURE NEUROSCIENCE
- Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery
- (2010) T. Kenakin et al. PHARMACOLOGICAL REVIEWS
- Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells
- (2009) Ewa Kozela et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
- (2008) P. Jeffrey Conn et al. NATURE REVIEWS DRUG DISCOVERY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More