Allosteric modulators of cannabinoid receptor 1: developing compounds for improved specificity

MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future

(2017) Vincent Simon et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution

(2017) Thuy Nguyen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1

(2017) Leepakshi Khurana et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures of agonist-bound human cannabinoid receptor CB1

(2017) Tian Hua et al.   NATURE

The great divide: Separation between in vitro and in vivo effects of PSNCBAM-based CB 1 receptor allosteric modulators

(2017) Thomas F. Gamage et al.   NEUROPHARMACOLOGY

The cannabinoid system and pain

(2017) Stephen G. Woodhams et al.   NEUROPHARMACOLOGY

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Synthesis and biological evaluation of indole-2-carboxamides bearing photoactivatable functionalities as novel allosteric modulators for the cannabinoid CB1 receptor

(2016) Chang-Jiang Qiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor

(2016) Thuy Nguyen et al.   MEDICINAL RESEARCH REVIEWS

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

Novel Allosteric Modulators of G Protein-coupled Receptors

(2015) Patrick R. Gentry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

(2015) Pushkar M. Kulkarni et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects

(2015) Bogna M Ignatowska-Jankowska et al.   NEUROPSYCHOPHARMACOLOGY

Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments

(2015) Mariano Stornaiuolo et al.   Scientific Reports

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

(2014) Thomas F. Gamage et al.   BEHAVIOURAL PHARMACOLOGY

Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications

(2014) N T Burford et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of the cannabinoid CB1 receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats

(2014) Li Jing et al.   DRUG AND ALCOHOL DEPENDENCE

Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)

(2014) Nadezhda German et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)

(2014) Leepakshi Khurana et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Membrane Proximal Region of the Cannabinoid Receptor CB1 N-Terminus Can Allosterically Modulate Ligand Affinity

(2013) Jonathan F. Fay et al.   BIOCHEMISTRY

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

(2013) Cristoforo Silvestri et al.   Cell Metabolism

Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor

(2013) Derek M. Shore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

(2013) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Relationship Study of Indole-2-carboxamides Identifies a Potent Allosteric Modulator for the Cannabinoid Receptor 1 (CB1)

(2013) Mariam M. Mahmoud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and GiProtein-independent ERK1/2 Kinase Activation

(2012) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1Receptors

(2012) Mark Bauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor

(2012) Francesco Piscitelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Profiling two indole-2-carboxamides for allosteric modulation of the CB1 receptor

(2012) Kwang H. Ahn et al.   JOURNAL OF NEUROCHEMISTRY

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

(2012) F. A. Pamplona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery?

(2010) Tricia H Smith et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of the Allosteric Antagonist 1-(4-Chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 Receptor Modulation in the Cerebellum

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

Positive allosteric modulation of the human cannabinoid (CB1) receptor by RTI-371, a selective inhibitor of the dopamine transporter

(2009) Hernán A. Navarro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

(2008) Roger G. Pertwee   ADDICTION BIOLOGY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats

(2007) J G Horswill et al.   BRITISH JOURNAL OF PHARMACOLOGY