The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis

Dose-dependent effect of cannabinoid WIN-55,212-2 on myelin repair following a demyelinating insult

(2020) J. Tomas-Roig et al.   Scientific Reports

Endocannabinoid Modulation of Microglial Phenotypes in Neuropathology

(2020) Mikiei Tanaka et al.   Frontiers in Neurology

The Synthetic Cannabinoid URB447 Reduces Brain Injury and the Associated White Matter Demyelination after Hypoxia-Ischemia in Neonatal Rats

(2020) Silvia Carloni et al.   ACS Chemical Neuroscience

A Guide to Targeting the Endocannabinoid System in Drug Design

(2020) Adam Stasiulewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blockade of the endovanilloid receptor, TRPV1, and of the endocannabinoid enzyme, FAAH, within the nucleus accumbens shell elicits anxiolytic-like effects in male rats

(2020) Thibaut R. Pardo-García et al.   NEUROSCIENCE LETTERS

Effects of EHP-101 on inflammation and remyelination in murine models of Multiple sclerosis

(2020) Carmen Navarrete et al.   NEUROBIOLOGY OF DISEASE

Crystal Structure of the Human Cannabinoid Receptor CB2

(2019) Xiaoting Li et al.   CELL

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

(2019) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Extensive Reliability Evaluation of Docking-Based Target-Fishing Strategies

(2019) Margherita Lapillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system

(2019) Francesca Gado et al.   BIOORGANIC CHEMISTRY

Exosomes From Astrocyte Processes: Signaling to Neurons

(2019) Arianna Venturini et al.   Frontiers in Pharmacology

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system

(2018) Andrea Chicca et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual cyclooxygenase–fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site

(2018) Michael C. Goodman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the first synthetic allosteric modulator of the CB2 receptors and evidence of its efficacy for neuropathic pain relief

(2018) Francesca Gado et al.   JOURNAL OF MEDICINAL CHEMISTRY

The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases

(2018) Valerio Chiurchiù et al.   PROGRESS IN NEUROBIOLOGY

Neuroprotective Effects of MAGL (Monoacylglycerol Lipase) Inhibitors in Experimental Ischemic Stroke

(2018) Sang-Ho Choi et al.   STROKE

The Endocannabinoid Reuptake Inhibitor WOBE437 Is Orally Bioavailable and Exerts Indirect Polypharmacological Effects via Different Endocannabinoid Receptors

(2018) Inés Reynoso-Moreno et al.   Frontiers in Molecular Neuroscience

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

(2018) Giulia Bononi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New approaches and challenges to targeting the endocannabinoid system

(2018) Vincenzo Di Marzo   NATURE REVIEWS DRUG DISCOVERY

Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high

(2018) A. Chicca et al.   Science Advances

Cannabinoid CB 2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB 1 Mechanism that is Independent of CB 2 Receptors in Mice

(2017) Ai-Ling Li et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Crystal structures of agonist-bound human cannabinoid receptor CB1

(2017) Tian Hua et al.   NATURE

Effects of natural and synthetic isothiocyanate-based H 2 S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels

(2017) Lorenzo Di Cesare Mannelli et al.   NEUROPHARMACOLOGY

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake

(2017) Andrea Chicca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage

(2017) Vanessa Petrucci et al.   Scientific Reports

Synthesis of part structures of Cryptococcus neoformans serotype C capsular polysaccharide

(2016) Lorenzo Guazzelli et al.   CARBOHYDRATE RESEARCH

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

The CB2 receptor and its role as a regulator of inflammation

(2016) Caroline Turcotte et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors

(2016) Elisa Nuti et al.   ChemMedChem

Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences

(2016) Silvia M. Tietz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Synthesis and structure activity relationship investigation of triazolo[1,5-a]pyrimidines as CB2 cannabinoid receptor inverse agonists

(2016) Mojgan Aghazadeh Tabrizi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

(2016) Margherita Brindisi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A2A-D2 receptor-receptor interaction modulates gliotransmitter release from striatal astrocyte processes

(2016) Chiara Cervetto et al.   JOURNAL OF NEUROCHEMISTRY

Microglia activation states and cannabinoid system: Therapeutic implications

(2016) M. Mecha et al.   PHARMACOLOGY & THERAPEUTICS

Effects of pro-inflammatory cytokines on cannabinoid CB1and CB2receptors in immune cells

(2015) L. Jean-Gilles et al.   Acta Physiologica

Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling

(2015) Lei Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid Signaling and Neuroinflammatory Diseases: A Melting pot for the Regulation of Brain Immune Responses

(2015) Valerio Chiurchiù et al.   Journal of Neuroimmune Pharmacology

4′-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation

(2015) Andrea Chicca et al.   Journal of Neuroinflammation

Lack of presynaptic interaction between glucocorticoid and CB 1 cannabinoid receptors in GABA- and glutamatergic terminals in the frontal cortex of laboratory rodents

(2015) Rafael M. Bitencourt et al.   NEUROCHEMISTRY INTERNATIONAL

Astrocyte-Dependent Vulnerability to Excitotoxicity in Spermine Oxidase-Overexpressing Mouse

(2015) Chiara Cervetto et al.   NEUROMOLECULAR MEDICINE

Calcium-permeable AMPA receptors trigger vesicular glutamate release from Bergmann gliosomes

(2015) Chiara Cervetto et al.   NEUROPHARMACOLOGY

Oxaliplatin evokes P2X7-dependent glutamate release in the cerebral cortex: A pain mechanism mediated by Pannexin 1

(2015) Lorenzo Di Cesare Mannelli et al.   NEUROPHARMACOLOGY

A multi-target approach for pain treatment

(2015) Natalia Malek et al.   PAIN

Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex

(2015) Monica Averna et al.   PLoS One

Anandamide, Acting viaCB2Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures

(2015) Natalia Malek et al.   NEURAL PLASTICITY

Functionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid System

(2014) Andrea Chicca et al.   ACS Chemical Biology

1,2-Dihydro-2-oxopyridine-3-carboxamides: The C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor

(2014) Valentina Lucchesi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Blockade of monoacylglycerol lipase inhibits oligodendrocyte excitotoxicity and prevents demyelinationin vivo

(2014) Ana Bernal-Chico et al.   GLIA

Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis

(2014) Alessandra Musella et al.   NEUROPHARMACOLOGY

The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis

(2014) Andrea Navarria et al.   PHARMACOLOGICAL RESEARCH

Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro

(2013) Emelie Janefjord et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors

(2013) G Pryce et al.   Multiple Sclerosis Journal

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold

(2012) Clementina Manera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potentiation of NMDA Receptor-Dependent Cell Responses by Extracellular High Mobility Group Box 1 Protein

(2012) Marco Pedrazzi et al.   PLoS One

Efficient double glycoconjugation to naturalize high molecular weight disperse dyes

(2011) Roberto Bianchini et al.   CARBOHYDRATE RESEARCH

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

(2011) A. M. Martin-Moreno et al.   MOLECULAR PHARMACOLOGY

The endocannabinoid system as a target for the treatment of neuronal damage

(2010) Javier Fernández-Ruiz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Microglia and neuroprotection: From in vitro studies to therapeutic applications

(2010) Elisabetta Polazzi et al.   PROGRESS IN NEUROBIOLOGY

Lactose as an inexpensive starting material for the preparation of aldohexos-5-uloses: synthesis of l-ribo and d-lyxo derivatives

(2009) Lorenzo Guazzelli et al.   CARBOHYDRATE RESEARCH

Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells

(2009) Ewa Kozela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells

(2008) Martina Landi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic potential of CB2 targeting in multiple sclerosis

(2008) Fabian Docagne et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats

(2008) Michelle Roche et al.   IMMUNOLOGY

The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation

(2008) Ana Rubio-Araiz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats

(2007) E J Rahn et al.   BRITISH JOURNAL OF PHARMACOLOGY

Control of Spasticity in a Multiple Sclerosis Model is mediated by CB1, not CB2, Cannabinoid Receptors

(2007) G Pryce et al.   BRITISH JOURNAL OF PHARMACOLOGY