Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology

Targeted Brain Delivery of Rabies Virus Glycoprotein 29-Modified Deferoxamine-Loaded Nanoparticles Reverses Functional Deficits in Parkinsonian Mice

(2018) Linhao You et al.   ACS Nano

Targeting the leptin receptor: To evaluate therapeutic efficacy and anti-tumor effects of Doxil, in vitro and in vivo in mice bearing C26 colon carcinoma tumor

(2018) Shahrzad Amiri Darban et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Crossing the blood-brain barrier with nanoparticles

(2018) Yiqun Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends

(2018) Hira Choudhury et al.   Drug Delivery and Translational Research

Insulin transport across the blood-brain barrier can occur independently of the insulin receptor

(2018) Elizabeth M. Rhea et al.   JOURNAL OF PHYSIOLOGY-LONDON

Size Limit and Energy Analysis of Nanoparticles during Wrapping Process by Membrane

(2018) Xinpei Meng et al.   Nanomaterials

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Receptor-Mediated Endocytosis of Nanoparticles: Roles of Shapes, Orientations, and Rotations of Nanoparticles

(2017) Huayuan Tang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Delivery of siRNA silencing P-gp in peptide-functionalized nanoparticles causes efflux modulation at the blood–brain barrier

(2017) Maria João Gomes et al.   Nanomedicine

The effect of nanoparticle size on the ability to cross the blood–brain barrier: an in vivo study

(2017) Oshra Betzer et al.   Nanomedicine

The role of non-endothelial cells on the penetration of nanoparticles through the blood brain barrier

(2017) Rui Pedro Moura et al.   PROGRESS IN NEUROBIOLOGY

Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

(2017) Y. Anraku et al.   Nature Communications

Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control

(2017) Roberta Haddad-Tóvolli et al.   Frontiers in Neuroscience

Rabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS

(2017) Karsten Hueffer et al.   Scientific Reports

Iron uptake and transport across physiological barriers

(2016) Kari A. Duck et al.   BIOMETALS

ABC transporters at the blood–brain barrier

(2016) Anne Mahringer et al.   Expert Opinion on Drug Metabolism & Toxicology

Role of scavenger receptors in peptide-based delivery of plasmid DNA across a blood–brain barrier model

(2016) Artita Srimanee et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The blood–brain barrier after stroke: Structural studies and the role of transcytotic vesicles

(2016) Michael J Haley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

(2016) Cláudia Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery

(2016) Simon G. Patching   MOLECULAR NEUROBIOLOGY

A comprehensive review of the neonatal Fc receptor and its application in drug delivery

(2016) João Pedro Martins et al.   PHARMACOLOGY & THERAPEUTICS

The role of the low-density lipoprotein receptor–related protein 1 (LRP-1) in regulating blood-brain barrier integrity

(2016) Yahui Zhao et al.   REVIEWS IN THE NEUROSCIENCES

Strategies for transporting nanoparticles across the blood–brain barrier

(2016) Tian-Tian Zhang et al.   Biomaterials Science

AD-Peptide Ligand of Nicotine Acetylcholine Receptors for Brain-Targeted Drug Delivery

(2015) Xiaoli Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier

(2015) Jason M. Lajoie et al.   Annual Review of Pharmacology and Toxicology

Therapeutic approaches of magnetic nanoparticles for the central nervous system

(2015) Fahima Dilnawaz et al.   DRUG DISCOVERY TODAY

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

Exploiting Bacterial Pathways for BBB Crossing with PLGA Nanoparticles Modified with a Mutated Form of Diphtheria Toxin (CRM197): In Vivo Experiments

(2015) G. Tosi et al.   MOLECULAR PHARMACEUTICS

Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors

(2015) Suraj Dixit et al.   Nanoscale

Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation

(2015) Yuanying Gong et al.   NEURO-ONCOLOGY

Anatomy and physiology of the blood–brain barrier

(2015) Yonatan Serlin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glial regulation of the blood-brain barrier in health and disease

(2015) Bieke Broux et al.   Seminars in Immunopathology

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Scavenger Receptor Structure and Function in Health and Disease

(2015) Izma Zani et al.   Cells

Role of the Blood–Brain Barrier in the Nutrition of the Central Nervous System

(2014) Patricia Campos-Bedolla et al.   ARCHIVES OF MEDICAL RESEARCH

Standardizing Scavenger Receptor Nomenclature

(2014) M. PrabhuDas et al.   JOURNAL OF IMMUNOLOGY

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

ET-61 * NOVEL LIPID NANOPARTICLES FOR THE DELIVERY OF NUCLEIC ACIDS TO GLIOBLASTOMA

(2014) A. T. Ashizawa et al.   NEURO-ONCOLOGY

Pharmacokinetics, Brain Delivery, and Efficacy in Brain Tumor-Bearing Mice of Glutathione Pegylated Liposomal Doxorubicin (2B3-101)

(2014) Pieter J. Gaillard et al.   PLoS One

Activated Scavenger Receptor A Promotes Glial Internalization of Aβ

(2014) He Zhang et al.   PLoS One

Blood-Brain Barrier Molecular Trojan Horse Enables Imaging of Brain Uptake of Radioiodinated Recombinant Protein in the Rhesus Monkey

(2013) Ruben J. Boado et al.   BIOCONJUGATE CHEMISTRY

LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma

(2013) Bo Zhang et al.   BIOMATERIALS

Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn

(2013) Philip R. Cooper et al.   BRAIN RESEARCH

A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA

(2013) Nicolina Cristina Sorrentino et al.   EMBO Molecular Medicine

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Blood–brain barrier opening to large molecules does not imply blood–brain barrier opening to small ions

(2013) E.J. Kang et al.   NEUROBIOLOGY OF DISEASE

Targeted Delivery of Nano-Therapeutics for Major Disorders of the Central Nervous System

(2013) Huile Gao et al.   PHARMACEUTICAL RESEARCH

Nanoparticle Mediated P-Glycoprotein Silencing for Improved Drug Delivery across the Blood-Brain Barrier: A siRNA-Chitosan Approach

(2013) Jostein Malmo et al.   PLoS One

Glucose-Coated Gold Nanoparticles Transfer across Human Brain Endothelium and Enter Astrocytes In Vitro

(2013) Radka Gromnicova et al.   PLoS One

Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier

(2013) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis

(2013) Fabrizio Vinante et al.   Toxins

The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increasesin vitrodrug delivery across blood-brain barrier cells

(2012) ML Pinzón-Daza et al.   BRITISH JOURNAL OF PHARMACOLOGY

Surface functionalization of nanoparticles for nanomedicine

(2012) Rubul Mout et al.   CHEMICAL SOCIETY REVIEWS

The ABC of the Blood-Brain Barrier - Regulation of Drug Efflux Pumps

(2012) Anne Mahringer et al.   CURRENT PHARMACEUTICAL DESIGN

Nanobiotechnology-based strategies for crossing the blood–brain barrier

(2012) Kewal K Jain   Nanomedicine

Neuroinflammation and Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy

(2012) Anna Carrano et al.   Neurodegenerative Diseases

Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish

(2012) J.W. Prokop et al.   PEPTIDES

A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys

(2012) Sachiko Ohshima-Hosoyama et al.   PLoS One

The ABCG2 resistance network of glioblastoma

(2011) Anne-Marie Bleau et al.   CELL CYCLE

Transcytosis of CRM197-grafted polybutylcyanoacrylate nanoparticles for delivering zidovudine across human brain-microvascular endothelial cells

(2011) Yung-Chih Kuo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

ABC Transporters in the CNS – An Inventory

(2011) A. M.S. Hartz et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

GLUT-1 glucose transporters in the blood-brain barrier: Differential phosphorylation

(2011) Kavi Devraj et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes

(2011) Robert Vácha et al.   NANO LETTERS

Can leptin-derived sequence-modified nanoparticles be suitable tools for brain delivery?

(2011) Giovanni Tosi et al.   Nanomedicine

Diphtheria Toxin Mutant CRM197-Mediated Transcytosis across Blood–Brain Barrier In Vitro

(2010) Ping Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Evidence for leptin receptor isoforms heteromerization at the cell surface

(2010) Johan Bacart et al.   FEBS LETTERS

The expression of LDL receptor in vessels with blood–brain barrier impairment in a stroke-prone hypertensive model

(2010) Masaki Ueno et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Neonatal Fc Receptor: From Immunity to Therapeutics

(2010) Timothy T. Kuo et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)

(2010) Karsten Ulbrich et al.   JOURNAL OF DRUG TARGETING

CRM197-Induced Blood–Brain Barrier Permeability Increase is Mediated by Upregulation of Caveolin-1 Protein

(2010) Ping Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Nanomedicine

(2010) Betty Y.S. Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Human Breast Cancer Resistance Protein (BCRP/ABCG2) Shows Conformational Changes with Mitoxantrone

(2010) Mark F. Rosenberg et al.   STRUCTURE

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

Scara5 Is a Ferritin Receptor Mediating Non-Transferrin Iron Delivery

(2009) Jau Yi Li et al.   DEVELOPMENTAL CELL

Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders

(2009) Eric Mills et al.   Future Medicinal Chemistry

Receptor-mediated therapeutic transport across the blood–brain barrier

(2009) Yun-Yan Wang et al.   Immunotherapy

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

(2009) Reinhard Gabathuler   NEUROBIOLOGY OF DISEASE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2

(2008) A Régina et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

(2008) Svetlana Stamatovic et al.   Current Neuropharmacology

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

(2008) Karsten Ulbrich et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The origins and evolution of “controlled” drug delivery systems

(2008) Allan S. Hoffman   JOURNAL OF CONTROLLED RELEASE

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier

(2008) Sandrine Dauchy et al.   JOURNAL OF NEUROCHEMISTRY

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

(2008) S.-F. Zhou   XENOBIOTICA