Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology

Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons

(2015) Changyi Ji et al.   JOURNAL OF NEUROCHEMISTRY

Ndfip1 attenuated 6-OHDA–induced iron accumulation via regulating the degradation of DMT1

(2015) Wenting Jia et al.   NEUROBIOLOGY OF AGING

Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor inhibit ferrous iron influx via divalent metal transporter 1 and iron regulatory protein 1 regulation in ventral mesencephalic neurons

(2014) Hao-Yun Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

(2014) R. C. McCarthy et al.   EMBO REPORTS

Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

(2014) William M Pardridge   Expert Opinion on Drug Delivery

A Novel Model for Brain Iron Uptake: Introducing the Concept of Regulation

(2014) Ian A Simpson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

(2014) Jason Howitt et al.   PLoS One

The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body

(2014) Christal A. Worthen et al.   Frontiers in Pharmacology

Brain angiotensin regulates iron homeostasis in dopaminergic neurons and microglial cells

(2013) Pablo Garrido-Gil et al.   EXPERIMENTAL NEUROLOGY

Ferroportin and Exocytoplasmic Ferroxidase Activity Are Required for Brain Microvascular Endothelial Cell Iron Efflux

(2013) Ryan C. McCarthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation

(2013) B. Acikyol et al.   NEUROSCIENCE

Absorption of Manganese and Iron in a Mouse Model of Hemochromatosis

(2013) Jonghan Kim et al.   PLoS One

Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation

(2012) Michael D. Garrick et al.   BIOMETALS

1B/(−)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310

(2012) Rosaria Ingrassia et al.   PLoS One

Placental fatty acid transport in maternal obesity

(2012) I. Cetin et al.   Journal of Developmental Origins of Health and Disease

A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic anemia and liver iron overload

(2011) Edouard Bardou-Jacquet et al.   BLOOD CELLS MOLECULES AND DISEASES

Expression of divalent metal transporter 1 in primary hippocampal neurons: reconsidering its role in non-transferrin-bound iron influx

(2011) Ilaria Pelizzoni et al.   JOURNAL OF NEUROCHEMISTRY

Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging

(2011) George Bartzokis et al.   NEUROPSYCHOPHARMACOLOGY

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Iron disorders of genetic origin: a changing world

(2011) Pierre Brissot et al.   TRENDS IN MOLECULAR MEDICINE

Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron

(2010) Darius J.R. Lane et al.   BIOCHEMICAL JOURNAL

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells

(2010) I. Andolfo et al.   HAEMATOLOGICA

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1

(2010) Jerome A. Roth et al.   JOURNAL OF NEUROCHEMISTRY

Not all DMT1 mutations lead to iron overload

(2009) Esther Blanco et al.   BLOOD CELLS MOLECULES AND DISEASES

Mammalian iron transport

(2009) Gregory Jon Anderson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clinical Perspectives on Hereditary Hemochromatosis

(2008) Oyekoya T. Ayonrinde et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Oligodendrocytes and myelination: The role of iron

(2008) Bozho Todorich et al.   GLIA

Steap Proteins: Implications for Iron and Copper Metabolism

(2008) Mitchell D. Knutson   NUTRITION REVIEWS

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat

(2003) Torben Moos et al.   JOURNAL OF NEUROCHEMISTRY