Brain-targeted drug delivery by manipulating protein corona functions

Short Peptide-Mediated Brain-Targeted Drug Delivery with Enhanced Immunocompatibility

(2019) Juan Guan et al.   MOLECULAR PHARMACEUTICS

Protein corona–mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses

(2018) Limei Shen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Formation of protein corona in vivo affects drug release from temperature-sensitive liposomes

(2018) Zahraa S. Al-Ahmady et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption

(2018) Juan Guan et al.   Nature Communications

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

(2017) Francesco Barbero et al.   SEMINARS IN IMMUNOLOGY

Biological Identity of Nanoparticles In Vivo : Clinical Implications of the Protein Corona

(2017) Giulio Caracciolo et al.   TRENDS IN BIOTECHNOLOGY

Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

(2017) Aman P. Mann et al.   Nature Communications

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

Cholera Toxin Subunit B Enabled Multifunctional Glioma-Targeted Drug Delivery

(2017) Juan Guan et al.   Advanced Healthcare Materials

Exploring Cellular Interactions of Liposomes Using Protein Corona Fingerprints and Physicochemical Properties

(2016) Arafeh Bigdeli et al.   ACS Nano

Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake

(2016) Vahid Mirshafiee et al.   BIOMATERIALS

Modulation of Amyloid-β1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier

(2016) Cristina Merino-Zamorano et al.   JOURNAL OF ALZHEIMERS DISEASE

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

(2016) Fangfang Chen et al.   Nature Nanotechnology

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Toxins and derivatives in molecular pharmaceutics: Drug delivery and targeted therapy

(2015) Changyou Zhan et al.   ADVANCED DRUG DELIVERY REVIEWS

AD-Peptide Ligand of Nicotine Acetylcholine Receptors for Brain-Targeted Drug Delivery

(2015) Xiaoli Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Liposome-based glioma targeted drug delivery enabled by stable peptide ligands

(2015) Xiaoli Wei et al.   JOURNAL OF CONTROLLED RELEASE

Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E

(2015) Ana Rute Neves et al.   NANOTECHNOLOGY

Mapping protein binding sites on the biomolecular corona of nanoparticles

(2015) Philip M. Kelly et al.   Nature Nanotechnology

A holistic approach to targeting disease with polymeric nanoparticles

(2015) Christopher J. Cheng et al.   NATURE REVIEWS DRUG DISCOVERY

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Phase I Study of GRN1005 in Recurrent Malignant Glioma

(2013) J. Drappatz et al.   CLINICAL CANCER RESEARCH

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier

(2013) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Challenges in design and characterization of ligand-targeted drug delivery systems

(2012) Silvia Muro   JOURNAL OF CONTROLLED RELEASE

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

(2012) Trevor J. Pugh et al.   NATURE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

(2012) Z. Cheng et al.   SCIENCE

Targeted drug delivery to tumors: Myths, reality and possibility

(2011) You Han Bae et al.   JOURNAL OF CONTROLLED RELEASE

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Time Evolution of the Nanoparticle Protein Corona

(2010) Eudald Casals et al.   ACS Nano

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

(2010) Thorsten Pflanzner et al.   NEUROBIOLOGY OF AGING

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Differential receptor-mediated drug targeting to the diseased brain

(2009) J Rip et al.   Expert Opinion on Drug Delivery

Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones

(2009) Anja Zensi et al.   JOURNAL OF CONTROLLED RELEASE

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

(2008) Karsten Ulbrich et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2

(2008) Michel Demeule et al.   JOURNAL OF NEUROCHEMISTRY

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA