Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma
Authors
Keywords
-
Journal
Cells
Volume 9, Issue 12, Pages 2540
Publisher
MDPI AG
Online
2020-11-25
DOI
10.3390/cells9122540
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation
- (2020) Xiang Chen et al. Aging-US
- Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis
- (2020) Zengdun Shi et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma
- (2020) Christophe A. Girard et al. CANCER RESEARCH
- Cell senescence and fibrotic lung diseases
- (2020) Rui-Ming Liu et al. EXPERIMENTAL GERONTOLOGY
- MASTL promotes cell contractility and motility through kinase-independent signaling
- (2020) Maria Emilia Taskinen et al. JOURNAL OF CELL BIOLOGY
- FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome
- (2020) Fuming Li et al. NATURE CELL BIOLOGY
- A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
- (2020) Masahiro Wakita et al. Nature Communications
- Senolytic CAR T cells reverse senescence-associated pathologies
- (2020) Corina Amor et al. NATURE
- Cellular senescence is associated with reorganization of the microtubule cytoskeleton
- (2019) Ossama Moujaber et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
- (2019) Rumani Singh et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The mTORC1-autophagy pathway is a target for senescent cell elimination
- (2019) Olena Kucheryavenko et al. BIOGERONTOLOGY
- Cellular Senescence: Aging, Cancer, and Injury
- (2019) Arianna Calcinotto et al. PHYSIOLOGICAL REVIEWS
- Senescent cell clearance by the immune system: Emerging therapeutic opportunities
- (2019) Larissa G.P. Langhi Prata et al. SEMINARS IN IMMUNOLOGY
- The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice
- (2019) Ana S. Leal et al. Scientific Reports
- Targeting senescent cells in translational medicine
- (2019) Marta Paez‐Ribes et al. EMBO Molecular Medicine
- An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma
- (2019) Julien Record et al. HAEMATOLOGICA
- Inducing and exploiting vulnerabilities for the treatment of liver cancer
- (2019) Cun Wang et al. NATURE
- MKL1 promotes endothelial-to-mesenchymal transition and liver fibrosis by activating TWIST1 transcription
- (2019) Zilong Li et al. Cell Death & Disease
- Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity
- (2019) Sandra Voringer et al. ONCOGENE
- Identification of Pparγ-modulated miRNA hubs that target the fibrotic tumor microenvironment
- (2019) Ivana Winkler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells
- (2018) Yi Na Yoon et al. BMC CANCER
- A versatile drug delivery system targeting senescent cells
- (2018) Daniel Muñoz‐Espín et al. EMBO Molecular Medicine
- Strategies targeting cellular senescence
- (2018) Yossi Ovadya et al. JOURNAL OF CLINICAL INVESTIGATION
- NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells
- (2018) Bo Hu et al. Journal of Hematology & Oncology
- Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
- (2018) Masatoshi Kudo et al. LANCET
- MASTL overexpression promotes chromosome instability and metastasis in breast cancer
- (2018) Samuel Rogers et al. ONCOGENE
- Two-Step Senescence-Focused Cancer Therapies
- (2018) Cynthia J. Sieben et al. TRENDS IN CELL BIOLOGY
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- The dynamic nature of senescence in cancer
- (2018) Soyoung Lee et al. NATURE CELL BIOLOGY
- Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosisex vivo
- (2017) Mareike Lehmann et al. EUROPEAN RESPIRATORY JOURNAL
- Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice
- (2017) Anja Moncsek et al. HEPATOLOGY
- Senescence-associated reprogramming promotes cancer stemness
- (2017) Maja Milanovic et al. NATURE
- A transient pool of nuclear F-actin at mitotic exit controls chromatin organization
- (2017) Christian Baarlink et al. NATURE CELL BIOLOGY
- Senescent cells: an emerging target for diseases of ageing
- (2017) Bennett G. Childs et al. NATURE REVIEWS DRUG DISCOVERY
- The novel MKL target gene myoferlin modulates expansion and senescence of hepatocellular carcinoma
- (2017) C Hermanns et al. ONCOGENE
- Cellular senescence mediates fibrotic pulmonary disease
- (2017) Marissa J. Schafer et al. Nature Communications
- Identification of HSP90 inhibitors as a novel class of senolytics
- (2017) Heike Fuhrmann-Stroissnigg et al. Nature Communications
- Cellular senescence drives age-dependent hepatic steatosis
- (2017) Mikolaj Ogrodnik et al. Nature Communications
- Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE 2 -Mediated Suppression of Antitumor Immunity
- (2017) Tze Mun Loo et al. Cancer Discovery
- Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells
- (2017) Krishna S. Tummala et al. Cell Reports
- Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions
- (2017) Jin Lee et al. Cell Reports
- Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma
- (2017) Heather L. Thompson et al. Frontiers in Immunology
- Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis
- (2017) Cynthia Yu-Wai-Man et al. Scientific Reports
- Progressive slowdown/prevention of cellular senescence by CD9-targeted delivery of rapamycin using lactose-wrapped calcium carbonate nanoparticles
- (2017) Raj Kumar Thapa et al. Scientific Reports
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
- (2016) Tobias Eggert et al. CANCER CELL
- Treatment Rationale and Study Design for the JUNIPER Study: A Randomized Phase III Study of Abemaciclib With Best Supportive Care Versus Erlotinib With Best Supportive Care in Patients With Stage IV Non–Small-Cell Lung Cancer With a Detectable KRAS Mutation Whose Disease Has Progressed After Platinum-Based Chemotherapy
- (2016) Jonathan W. Goldman et al. Clinical Lung Cancer
- Conserved and novel functions of programmed cellular senescence during vertebrate development
- (2016) Hongorzul Davaapil et al. DEVELOPMENT
- Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
- (2016) Marco Demaria et al. Cancer Discovery
- Unravelling a new mechanism linking actin polymerization and gene transcription
- (2016) Susanne Muehlich et al. Nucleus
- Unravelling a new mechanism linking actin polymerization and gene transcription
- (2016) Susanne Muehlich et al. Nucleus
- Hepatocellular carcinoma
- (2016) Josep M. Llovet et al. Nature Reviews Disease Primers
- Pro-senescence therapy for hepatocellular carcinoma
- (2016) Susanne Muehlich et al. Aging-US
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Cellular senescence-like features of lung fibroblasts derived from idiopathic pulmonary fibrosis patients
- (2015) Hagai Yanai et al. Aging-US
- Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis
- (2015) Thomas H. Sisson et al. AMERICAN JOURNAL OF PATHOLOGY
- Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts
- (2015) Hyun Lim et al. BIOCHEMICAL PHARMACOLOGY
- Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice
- (2015) L. Lan et al. EMBO JOURNAL
- Clinical strategies and animal models for developing senolytic agents
- (2015) James L. Kirkland et al. EXPERIMENTAL GERONTOLOGY
- Genetic Landscape and Biomarkers of Hepatocellular Carcinoma
- (2015) Jessica Zucman-Rossi et al. GASTROENTEROLOGY
- Dysregulated serum response factor triggers formation of hepatocellular carcinoma
- (2015) Stefan Ohrnberger et al. HEPATOLOGY
- The Role of Aging in Idiopathic Pulmonary Fibrosis
- (2015) Joseph Leung et al. LUNG
- Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
- (2015) Nicolás Herranz et al. NATURE CELL BIOLOGY
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Palbociclib in Hormone-Receptor–Positive Advanced Breast Cancer
- (2015) Nicholas C. Turner et al. NEW ENGLAND JOURNAL OF MEDICINE
- Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration
- (2015) Philipp Kircher et al. Science Signaling
- Targeting CDK4 and CDK6: From Discovery to Therapy
- (2015) C. J. Sherr et al. Cancer Discovery
- Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration
- (2015) Philipp Kircher et al. Science Signaling
- Cellular Mechanisms of Tissue Fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription
- (2014) Pei-Suen Tsou et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Revealing the Pathogenic and Aging-related Mechanisms of the Enigmatic Idiopathic Pulmonary Fibrosis. An Integral Model
- (2014) Moisés Selman et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling
- (2014) Mark R. Lundquist et al. CELL
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- Cellular senescence: from physiology to pathology
- (2014) Daniel Muñoz-Espín et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Cancer incidence and mortality in France over the 1980–2012 period: Solid tumors
- (2014) F. Binder-Foucard et al. REVUE D EPIDEMIOLOGIE ET DE SANTE PUBLIQUE
- Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance
- (2014) L. Hecker et al. Science Translational Medicine
- Immunosurveillance of senescent cells: the bright side of the senescence program
- (2013) Adi Sagiv et al. BIOGERONTOLOGY
- Mechanistic links between aging and lung fibrosis
- (2013) Victor J. Thannickal BIOGERONTOLOGY
- Tumoricidal effects of the JAK inhibitor Ruxolitinib (INC424) on hepatocellular carcinoma in vitro
- (2013) George S. Wilson et al. CANCER LETTERS
- Myoferlin Is a Key Regulator of EGFR Activity in Breast Cancer
- (2013) A. Turtoi et al. CANCER RESEARCH
- Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence
- (2013) P. D. Angelini et al. CANCER RESEARCH
- Programmed Cell Senescence during Mammalian Embryonic Development
- (2013) Daniel Muñoz-Espín et al. CELL
- Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)
- (2013) Christoph Garbers et al. CELL CYCLE
- Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence
- (2013) Veronika Hampl et al. EMBO Molecular Medicine
- Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma
- (2013) Virginia Hernandez–Gea et al. GASTROENTEROLOGY
- Serum response factor induces epithelial to mesenchymal transition with resistance to sorafenib in hepatocellular carcinoma
- (2013) JUN SANG BAE et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis
- (2013) Yong Zhou et al. JOURNAL OF CLINICAL INVESTIGATION
- Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
- (2013) Shin Yoshimoto et al. NATURE
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL
- (2013) C. Baarlink et al. SCIENCE
- Is cellular senescence an example of antagonistic pleiotropy?
- (2012) Stefano Giaimo et al. AGING CELL
- Abnormal Lung Aging in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis
- (2012) Rosa Faner et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Aging, Cellular Senescence, and Cancer
- (2012) Judith Campisi Annual Review of Physiology
- Natural and synthetic modulators of SK (Kca2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7
- (2012) V Chubanov et al. BRITISH JOURNAL OF PHARMACOLOGY
- Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies
- (2012) L. Hoenicke et al. CARCINOGENESIS
- Myocardin-related transcription factor A regulates expression of Bok and Noxa and is involved in apoptotic signalling
- (2012) Dmitry Shaposhnikov et al. CELL CYCLE
- Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells
- (2012) Marie-José Blivet-Van Eggelpoël et al. JOURNAL OF HEPATOLOGY
- Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
- (2012) Nicola Aceto et al. NATURE MEDICINE
- Myoferlin Depletion in Breast Cancer Cells Promotes Mesenchymal to Epithelial Shape Change and Stalls Invasion
- (2012) Ruth Li et al. PLoS One
- Changes in primary lymphoid organs with aging
- (2012) Ivan K. Chinn et al. SEMINARS IN IMMUNOLOGY
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Myocardin-related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung Fibroblasts
- (2011) Larry L. Luchsinger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PKI-587 and Sorafenib Targeting PI3K/AKT/mTOR and Ras/Raf/MAPK Pathways Synergistically Inhibit HCC Cell Proliferation
- (2011) Roberto Gedaly et al. JOURNAL OF SURGICAL RESEARCH
- Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- (2011) Tae-Won Kang et al. NATURE
- Hepatocellular Carcinoma
- (2011) Hashem B. El-Serag NEW ENGLAND JOURNAL OF MEDICINE
- The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1
- (2011) S Muehlich et al. ONCOGENE
- Mechanistic modeling of the effects of myoferlin on tumor cell invasion
- (2011) M. C. Eisenberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3
- (2011) Fang-Ming Gu WORLD JOURNAL OF GASTROENTEROLOGY
- Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
- (2010) Shunsuke Minagawa et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence
- (2010) Agustin Chicas et al. CANCER CELL
- Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction
- (2010) Eric M. Small et al. CIRCULATION RESEARCH
- Oncogene-induced senescence: the bright and dark side of the response
- (2010) Vassilis G Gorgoulis et al. CURRENT OPINION IN CELL BIOLOGY
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib
- (2010) Hayato Hikita et al. HEPATOLOGY
- Clinical significance of Cox-2, Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC)
- (2010) Yu Yang et al. MEDICAL ONCOLOGY
- The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
- (2010) Joon-Il Jun et al. NATURE CELL BIOLOGY
- Linking actin dynamics and gene transcription to drive cellular motile functions
- (2010) Eric N. Olson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells
- (2010) Aya Takesono et al. PLoS One
- Inflammatory networks during cellular senescence: causes and consequences
- (2010) Adam Freund et al. TRENDS IN MOLECULAR MEDICINE
- Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-β
- (2009) Nathan Sandbo et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility
- (2009) T. Y. Kim et al. CANCER AND METASTASIS REVIEWS
- Myoferlin is required for insulin-like growth factor response and muscle growth
- (2009) Alexis R. Demonbreun et al. FASEB JOURNAL
- Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence
- (2009) Peter D. Adams MOLECULAR CELL
- Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
- (2009) S. Inokuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cellular senescence, ageing and disease
- (2008) D. G. A. Burton AGE
- Senescence and immortality in hepatocellular carcinoma
- (2008) Mehmet Ozturk et al. CANCER LETTERS
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
- Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
- (2008) Narendra Wajapeyee et al. CELL
- Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
- (2008) Juan C. Acosta et al. CELL
- Senescence of Activated Stellate Cells Limits Liver Fibrosis
- (2008) Valery Krizhanovsky et al. CELL
- DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma
- (2008) W. Xue et al. GENES & DEVELOPMENT
- Serum-Induced Phosphorylation of the Serum Response Factor Coactivator MKL1 by the Extracellular Signal-Regulated Kinase 1/2 Pathway Inhibits Its Nuclear Localization
- (2008) S. Muehlich et al. MOLECULAR AND CELLULAR BIOLOGY
- Orchestrating the orchestrators: chemokines in control of T cell traffic
- (2008) Shannon K Bromley et al. NATURE IMMUNOLOGY
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
- Many roads lead to oncogene-induced senescence
- (2008) S Courtois-Cox et al. ONCOGENE
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
- Cellular and molecular mechanisms of fibrosis
- (2007) TA Wynn JOURNAL OF PATHOLOGY
- Hepatocellular carcinoma: Epidemiology and clinical aspects
- (2007) Roberto Mazzanti et al. MOLECULAR ASPECTS OF MEDICINE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started