Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis

Smooth Muscle α-Actin Deficiency Leads to Decreased Liver Fibrosis via Impaired Cytoskeletal Signaling in Hepatic Stellate Cells

(2019) Don C. Rockey et al.   AMERICAN JOURNAL OF PATHOLOGY

Liver fibrosis: Direct antifibrotic agents and targeted therapies

(2018) Detlef Schuppan et al.   MATRIX BIOLOGY

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of the actin cytoskeleton via myocardin leads to increased expression of type 1 collagen

(2017) Zengdun Shi et al.   LABORATORY INVESTIGATION

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling

(2016) Wenfang Tian et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution

(2016) Andrea Baiocchini et al.   PLoS One

Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

(2015) Thomas H. Sisson et al.   AMERICAN JOURNAL OF PATHOLOGY

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Actin Dynamics, Architecture, and Mechanics in Cell Motility

(2014) Laurent Blanchoin et al.   PHYSIOLOGICAL REVIEWS

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Smooth Muscle α Actin (Acta2) and Myofibroblast Function during Hepatic Wound Healing

(2013) Don C. Rockey et al.   PLoS One

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Endothelin and hepatic wound healing

(2011) Al-karim Khimji et al.   PHARMACOLOGICAL RESEARCH

Actin cytoskeleton in myofibroblast differentiation: Ultrastructure defining form and driving function

(2011) Nathan Sandbo et al.   Translational Research

Current status of novel antifibrotic therapies in patients with chronic liver disease

(2011) Michal Cohen-Naftaly et al.   Therapeutic Advances in Gastroenterology

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

(2010) Eric M. Small et al.   CIRCULATION RESEARCH

Interferon-γ-mediated Inhibition of Serum Response Factor-dependent Smooth Muscle-specific Gene Expression

(2010) Zengdun Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ERK Nuclear Translocation Is Dimerization-independent but Controlled by the Rate of Phosphorylation

(2009) Diane S. Lidke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene expression profiling and functional assays of activated hepatic stellate cells suggest that myocardin has a role in activation

(2009) Hideaki Shimada et al.   LIVER INTERNATIONAL

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS