Multi-color Molecular Visualization of Signaling Proteins Reveals How C-Terminal Src Kinase Nanoclusters Regulate T Cell Receptor Activation

Machine learning for cluster analysis of localization microscopy data

(2020) David J. Williamson et al.   Nature Communications

Can single molecule localization microscopy detect nanoclusters in T cells?

(2019) Kristen Feher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

(2019) Guillaume Voisinne et al.   NATURE IMMUNOLOGY

Capturing resting T cells: the perils of PLL

(2018) Ana Mafalda Santos et al.   NATURE IMMUNOLOGY

TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells

(2018) Benedikt Rossboth et al.   NATURE IMMUNOLOGY

A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22

(2018) Torkel Vang et al.   Science Signaling

Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation

(2018) Yair Razvag et al.   Nature Communications

A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22

(2018) Torkel Vang et al.   Science Signaling

Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2

(2018) Cara Bray et al.   Frontiers in Immunology

Super-resolution microscopy with DNA-PAINT

(2017) Joerg Schnitzbauer et al.   Nature Protocols

3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse

(2017) Juliette Griffié et al.   Scientific Reports

TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22

(2017) Alicia M. Wallis et al.   Scientific Reports

Cooperative Clustering Digitizes Biochemical Signaling and Enhances its Fidelity

(2016) Edward Roob et al.   BIOPHYSICAL JOURNAL

A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli

(2016) Zachary B Katz et al.   NATURE IMMUNOLOGY

Quantitative super-resolution imaging with qPAINT

(2016) Ralf Jungmann et al.   NATURE METHODS

Varying label density allows artifact-free analysis of membrane-protein nanoclusters

(2016) Florian Baumgart et al.   NATURE METHODS

Optical imaging of individual biomolecules in densely packed clusters

(2016) Mingjie Dai et al.   Nature Nanotechnology

A Bayesian cluster analysis method for single-molecule localization microscopy data

(2016) Juliette Griffié et al.   Nature Protocols

The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors

(2016) Dominique Davidson et al.   Cell Reports

Bayesian cluster identification in single-molecule localization microscopy data

(2015) Patrick Rubin-Delanchy et al.   NATURE METHODS

Quantitative Localization Microscopy: Effects of Photophysics and Labeling Stoichiometry

(2015) Robert P. J. Nieuwenhuizen et al.   PLoS One

Small molecule inhibition of Csk alters affinity recognition by T cells

(2015) Boryana N Manz et al.   eLife

Method for co-cluster analysis in multichannel single-molecule localisation data

(2014) Jérémie Rossy et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT

(2014) Ralf Jungmann et al.   NATURE METHODS

PTPN22: the archetypal non-HLA autoimmunity gene

(2014) Stephanie M. Stanford et al.   Nature Reviews Rheumatology

Stochastic approach to the molecular counting problem in superresolution microscopy

(2014) Geoffrey C. Rollins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAG - a multipurpose transmembrane adaptor protein

(2013) M Hrdinka et al.   ONCOGENE

The Autoimmunity Risk Variant LYP-W620 Cooperates with CSK in the Regulation of TCR Signaling

(2013) María Luisa de la Puerta et al.   PLoS One

Super-resolution characterization of TCR-dependent signaling clusters

(2012) Eilon Sherman et al.   IMMUNOLOGICAL REVIEWS

LYP inhibits T-cell activation when dissociated from CSK

(2012) Torkel Vang et al.   Nature Chemical Biology

Conformational states of the kinase Lck regulate clustering in early T cell signaling

(2012) Jérémie Rossy et al.   NATURE IMMUNOLOGY

Counting single photoactivatable fluorescent molecules by photoactivated localization microscopy (PALM)

(2012) S.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen

(2011) S. Thomas et al.   BLOOD

Coordinate-based colocalization analysis of single-molecule localization microscopy data

(2011) Sebastian Malkusch et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

(2011) David J Williamson et al.   NATURE IMMUNOLOGY

The effects of membrane compartmentalization of csk on TCR signaling

(2010) Pavel Otáhal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Single-Molecule Kinetics and Super-Resolution Microscopy by Fluorescence Imaging of Transient Binding on DNA Origami

(2010) Ralf Jungmann et al.   NANO LETTERS

PEST family phosphatases in immunity, autoimmunity, and autoinflammatory disorders

(2009) André Veillette et al.   IMMUNOLOGICAL REVIEWS

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

(2009) J. Zikherman et al.   JOURNAL OF IMMUNOLOGY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion

(2009) T. S. van Zanten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA