The Autoimmunity Risk Variant LYP-W620 Cooperates with CSK in the Regulation of TCR Signaling

LYP inhibits T-cell activation when dissociated from CSK

(2012) Torkel Vang et al.   Nature Chemical Biology

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

(2010) Edoardo Fiorillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAN: a database for prediction of protein-protein interaction of modular domains mediated by linear motifs

(2009) J. A. Encinar et al.   BIOINFORMATICS

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

(2009) J. Zikherman et al.   JOURNAL OF IMMUNOLOGY

Characterization of New Substrates Targeted By Yersinia Tyrosine Phosphatase YopH

(2009) María Luisa de la Puerta et al.   PLoS One

Protein Tyrosine Phosphatases in Autoimmunity

(2008) Torkel Vang et al.   Annual Review of Immunology

Structural Basis for the Recognition of c-Src by Its Inactivator Csk

(2008) Nicholas M. Levinson et al.   CELL

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

(2008) Johanna Aarnisalo et al.   JOURNAL OF AUTOIMMUNITY

PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis

(2008) Ann Kari Lefvert et al.   JOURNAL OF NEUROIMMUNOLOGY