Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

(2019) Javier Celis-Gutierrez et al.   Cell Reports

A composition-dependent molecular clutch between T cell signaling condensates and actin

(2019) Jonathon A Ditlev et al.   eLife

Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response

(2018) Amy H. Andreotti et al.   Annual Review of Immunology

Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells

(2018) Akiko Seki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+T cells

(2018) Guillaume Gaud et al.   Science Signaling

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+T cells

(2018) Guillaume Gaud et al.   Science Signaling

Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt

(2018) Shu-Lin Liu et al.   MOLECULAR CELL

A high-avidity biosensor reveals plasma membrane PI(3,4)P2 is predominantly a class I PI3K signaling product

(2018) Brady D. Goulden et al.   JOURNAL OF CELL BIOLOGY

Themis-associated phosphatase activity controls signaling in T cell development

(2018) Monika Mehta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatase PP2A is essential for TH17 differentiation

(2018) Qin Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction

(2017) Jérôme Bouchet et al.   JOURNAL OF IMMUNOLOGY

Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry

(2017) Etienne Caron et al.   Cell Reports

Co‐recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR‐induced ubiquitylation

(2016) Guillaume Voisinne et al.   Molecular Systems Biology

Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

(2016) Ekaterina Zvezdova et al.   Science Signaling

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

(2016) Neel H Shah et al.   eLife

Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

(2016) Ekaterina Zvezdova et al.   Science Signaling

Dynamic Regulation of TCR–Microclusters and the Microsynapse for T Cell Activation

(2016) Akiko Hashimoto-Tane et al.   Frontiers in Immunology

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

(2015) Lakshmi Balagopalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cell activation

(2015) Mingjin Yang et al.   NATURE IMMUNOLOGY

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

(2015) Sudha Kumari et al.   eLife

Proline-serine-threonine phosphatase interacting protein 1 inhibition of T-cell receptor signaling depends on its SH3 domain

(2014) Tamara Marcos et al.   FEBS Journal

A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards

(2014) Jacek R. Wiśniewski et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

(2014) Romain Roncagalli et al.   NATURE IMMUNOLOGY

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development

(2013) W. Paster et al.   JOURNAL OF IMMUNOLOGY

The Human Minor Histocompatibility Antigen1 Is a RhoGAP

(2013) Bart-Jan de Kreuk et al.   PLoS One

Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation

(2011) Rémi Lasserre et al.   JOURNAL OF CELL BIOLOGY

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Slow Down and Survive: Enigmatic Immunoregulation by BTLA and HVEM

(2010) Theresa L. Murphy et al.   Annual Review of Immunology

Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases

(2010) Stephanie M. Stanford et al.   Seminars in Immunopathology

CORUM: the comprehensive resource of mammalian protein complexes—2009

(2009) Andreas Ruepp et al.   NUCLEIC ACIDS RESEARCH