- Home
- Publications
- Publication Search
- Publication Details
Title
PTPN22: the archetypal non-HLA autoimmunity gene
Authors
Keywords
-
Journal
Nature Reviews Rheumatology
Volume 10, Issue 10, Pages 602-611
Publisher
Springer Nature
Online
2014-07-08
DOI
10.1038/nrrheum.2014.109
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- PTPN22 Controls the Germinal Center by Influencing the Numbers and Activity of T Follicular Helper Cells
- (2014) C. J. Maine et al. JOURNAL OF IMMUNOLOGY
- Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus
- (2014) Hui-Hsin Chang et al. ARTHRITIS RESEARCH & THERAPY
- Identification of thePTPN22functional variant R620W as susceptibility genetic factor for giant cell arteritis
- (2013) A Serrano et al. ANNALS OF THE RHEUMATIC DISEASES
- Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease
- (2013) Nunzio Bottini et al. Annual Review of Immunology
- Genome-Wide Association Study of Dermatomyositis Reveals Genetic Overlap With Other Autoimmune Disorders
- (2013) Frederick W. Miller et al. ARTHRITIS AND RHEUMATISM
- Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia
- (2013) S. J. Hebbring et al. BLOOD
- Loss of Protein Tyrosine Phosphatase Nonreceptor Type 22 Regulates Interferon-γ–Induced Signaling in Human Monocytes
- (2013) Marianne R. Spalinger et al. GASTROENTEROLOGY
- The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses
- (2013) Torkel Vang et al. HUMAN IMMUNOLOGY
- The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity
- (2013) Yaya Wang et al. IMMUNITY
- A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models
- (2013) Xuezhi Dai et al. JOURNAL OF CLINICAL INVESTIGATION
- Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways
- (2013) John C. Cambier JOURNAL OF CLINICAL INVESTIGATION
- Different Modulation of Ptpn22 in Effector and Regulatory T Cells Leads to Attenuation of Autoimmune Diabetes in Transgenic Nonobese Diabetic Mice
- (2013) L.-T. Yeh et al. JOURNAL OF IMMUNOLOGY
- Metaanalysis of the Association of Smoking and PTPN22 R620W Genotype on Autoantibody Status and Radiological Erosions in Rheumatoid Arthritis
- (2013) L. H. Taylor et al. JOURNAL OF RHEUMATOLOGY
- Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
- (2013) Anne Hinks et al. NATURE GENETICS
- Genetics and epigenetics of rheumatoid arthritis
- (2013) Sebastien Viatte et al. Nature Reviews Rheumatology
- Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA
- (2013) Merlyn J Kaalla et al. Pediatric Rheumatology
- Independent replication analysis of genetic loci with previous evidence of association with juvenile idiopathic arthritis
- (2013) Justine A Ellis et al. Pediatric Rheumatology
- PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes
- (2013) Bahram Namjou et al. PLoS One
- Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis
- (2013) Chun-Huang Huang et al. RHEUMATOLOGY INTERNATIONAL
- Distribution patterns of variability for 18 immune system genes in Amerindians - relationship with history and epidemiology
- (2013) J. D. Lindenau et al. TISSUE ANTIGENS
- Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients
- (2012) Sebastien Viatte et al. ANNALS OF THE RHEUMATIC DISEASES
- Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT
- (2012) R. Negro et al. BLOOD
- PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes-Associated Allele Is Not a Loss-of-Function Variant
- (2012) P. Zheng et al. DIABETES
- Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue
- (2012) J Zheng et al. GENES AND IMMUNITY
- Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity
- (2012) Stephanie M. Stanford et al. IMMUNOLOGY
- PTPN22 Alters the Development of Regulatory T Cells in the Thymus
- (2012) C. J. Maine et al. JOURNAL OF IMMUNOLOGY
- LYP inhibits T-cell activation when dissociated from CSK
- (2012) Torkel Vang et al. Nature Chemical Biology
- CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation
- (2012) Nataly Manjarrez-Orduño et al. NATURE GENETICS
- Protein tyrosine phosphatases in lymphocyte activation and autoimmunity
- (2012) Inmoo Rhee et al. NATURE IMMUNOLOGY
- Genetically Distinct Subsets within ANCA-Associated Vasculitis
- (2012) Paul A. Lyons et al. NEW ENGLAND JOURNAL OF MEDICINE
- PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis
- (2012) Hui-Hsin Chang et al. PLoS One
- PTPN22 R620W polymorphism in the ANCA-associated vasculitides
- (2012) Davide Martorana et al. RHEUMATOLOGY
- Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function
- (2012) R. J. Brownlie et al. Science Signaling
- The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls
- (2012) Marcus Ronninger et al. Genome Medicine
- Protein tyrosine phosphatase-22 (PTPN-22) polymorphism in the pathogenesis of chronic urticaria
- (2011) Zenon Brzoza et al. ALLERGY
- Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus
- (2011) E. Sanchez et al. ANNALS OF THE RHEUMATIC DISEASES
- Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis
- (2011) M. Corr et al. ANNALS OF THE RHEUMATIC DISEASES
- Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?
- (2011) Garth L. Burn et al. FEBS LETTERS
- The PTPN22*R620W polymorphism does not confer genetic susceptibility to antiphospholipid syndrome in the Spanish population
- (2011) J. Castro-Marrero et al. International Journal of Immunogenetics
- TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis
- (2011) Claire Immediato Daïen et al. JOINT BONE SPINE
- The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
- (2011) Laurence Menard et al. JOURNAL OF CLINICAL INVESTIGATION
- Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant
- (2011) T. Habib et al. JOURNAL OF IMMUNOLOGY
- Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells
- (2011) Stephanie M. Stanford et al. JOURNAL OF MEDICINAL CHEMISTRY
- Evidence for PTPN22 R620W Polymorphism As the Sole Common Risk Variant for Rheumatoid Arthritis in the 1p13.2 Region
- (2011) J.-E. MARTIN et al. JOURNAL OF RHEUMATOLOGY
- The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
- (2011) Jinyi Zhang et al. NATURE GENETICS
- Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis
- (2011) Kristina Juneblad et al. ARTHRITIS RESEARCH & THERAPY
- Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy
- (2011) Olga Gorlova et al. PLoS Genetics
- Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti–dsDNA Autoantibody Production
- (2011) Sharon A. Chung et al. PLoS Genetics
- Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis
- (2011) Yannick Allanore et al. PLoS Genetics
- Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis
- (2010) L. Diaz-Gallo et al. ANNALS OF THE RHEUMATIC DISEASES
- A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
- (2010) L. Padyukov et al. ANNALS OF THE RHEUMATIC DISEASES
- The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples
- (2010) Luis Rodríguez-Rodríguez et al. ARTHRITIS AND RHEUMATISM
- Allele and haplotype frequency distribution inPTPN22gene across variable ethnic groups: Implications for genetic association studies for autoimmune diseases
- (2010) Tulio C. Lins et al. AUTOIMMUNITY
- A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles
- (2010) M L Budarf et al. GENES AND IMMUNITY
- PTPN22 1858C>T polymorphism is strongly associated with rheumatoid arthritis but not with a response to methotrexate therapy
- (2010) Edyta Majorczyk et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue
- (2010) Edoardo Fiorillo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update
- (2010) WW Lea et al. LUPUS
- Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
- (2010) John D Reveille et al. NATURE GENETICS
- Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
- (2010) Timothy R D J Radstake et al. NATURE GENETICS
- A CD8+ T cell transcription signature predicts prognosis in autoimmune disease
- (2010) Eoin F McKinney et al. NATURE MEDICINE
- A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register
- (2010) D Plant et al. PHARMACOGENOMICS JOURNAL
- A PTPN22 promoter polymorphism −1123G>C is associated with RA pathogenesis in Chinese
- (2010) Jian-Jun Huang et al. RHEUMATOLOGY INTERNATIONAL
- Association of the PTPN22 gene (-1123G > C) polymorphism with rheumatoid arthritis in Chinese patients
- (2010) X. Feng et al. TISSUE ANTIGENS
- Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis
- (2009) A. Hinks et al. ANNALS OF THE RHEUMATIC DISEASES
- Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis
- (2009) Edward J Carr et al. BMC Medical Genetics
- PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background
- (2009) J. Zikherman et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling
- (2009) A. F. Arechiga et al. JOURNAL OF IMMUNOLOGY
- A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
- (2009) Vesela Gateva et al. NATURE GENETICS
- Association ofPTPN22gene functional variants with development of pulmonary tuberculosis in Moroccan population
- (2009) H. Lamsyah et al. TISSUE ANTIGENS
- Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
- (2008) C Potter et al. ANNALS OF THE RHEUMATIC DISEASES
- Testing for linkage and association with rheumatoid arthritis a ptpn22 promoter polymorphism reported to be associated and linked with type 1 diabetes in the Caucasian population
- (2008) P Dieude et al. ANNALS OF THE RHEUMATIC DISEASES
- ThePTPN22620W allele confers susceptibility to systemic sclerosis: Findings of a large case–control study of European Caucasians and a meta‐analysis
- (2008) P. Dieudé et al. ARTHRITIS AND RHEUMATISM
- The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients
- (2008) H. Chinoy et al. ARTHRITIS AND RHEUMATISM
- A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus
- (2008) V. Orru et al. HUMAN MOLECULAR GENETICS
- Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis
- (2008) V. Goeb et al. RHEUMATOLOGY
- PTPN22 gene polymorphism in Takayasu's arteritis
- (2008) N. Sahin et al. RHEUMATOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More