Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2
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Title
Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-11-12
DOI
10.3389/fimmu.2018.02595
References
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Related references
Note: Only part of the references are listed.- Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22
- (2017) Rebecca J. Brownlie et al. Nature Communications
- Use of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytes
- (2017) Valentina Perri et al. PLoS One
- Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice
- (2016) Shatakshi Sood et al. JOURNAL OF IMMUNOLOGY
- The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals
- (2014) Robert J Salmond et al. NATURE IMMUNOLOGY
- Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus
- (2014) Hui-Hsin Chang et al. ARTHRITIS RESEARCH & THERAPY
- A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models
- (2013) Xuezhi Dai et al. JOURNAL OF CLINICAL INVESTIGATION
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes-Associated Allele Is Not a Loss-of-Function Variant
- (2012) P. Zheng et al. DIABETES
- PTPN22 Alters the Development of Regulatory T Cells in the Thymus
- (2012) C. J. Maine et al. JOURNAL OF IMMUNOLOGY
- PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis
- (2012) Hui-Hsin Chang et al. PLoS One
- Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function
- (2012) R. J. Brownlie et al. Science Signaling
- The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls
- (2012) Marcus Ronninger et al. Genome Medicine
- Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen
- (2011) S. Thomas et al. BLOOD
- The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
- (2011) Jinyi Zhang et al. NATURE GENETICS
- Identification of a variant form of tyrosine phosphatase LYP
- (2010) Shaofeng Wang et al. BMC MOLECULAR BIOLOGY
- PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background
- (2009) J. Zikherman et al. JOURNAL OF IMMUNOLOGY
- PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis
- (2008) Ann Kari Lefvert et al. JOURNAL OF NEUROIMMUNOLOGY
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