Oxidants, Antioxidants and Thiol Redox Switches in the Control of Regulated Cell Death Pathways

Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation

(2020) Ilana Braunstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

(2020) Alexandr A. Kapralov et al.   Nature Chemical Biology

Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

(2020) Jonathan Muri et al.   eLife

Control of protein function through oxidation and reduction of persulfidated states

(2020) É. Dóka et al.   Science Advances

Multiple functions of 2-Cys peroxiredoxins, I and II, and their regulations via post-translational modifications

(2020) Sue Goo Rhee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes

(2019) Sunmi Lee et al.   Cell Reports

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease

(2019) Md Imamul Islam et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

(2019) Evijola Llabani et al.   Nature Chemistry

Prdx4 limits caspase‐1 activation and restricts inflammasome‐mediated signaling by extracellular vesicles

(2019) Simone Lipinski et al.   EMBO JOURNAL

Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis

(2019) Jye‐Lin Hsu et al.   EMBO Molecular Medicine

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

(2019) Mark M. Hughes et al.   Cell Reports

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

(2019) Jasmina Zivanovic et al.   Cell Metabolism

Protein S-Nitrosylation: Determinants of Specificity and Enzymatic Regulation of S-Nitrosothiol-Based Signaling

(2018) Colin T. Stomberski et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death

(2018) Sabrina Romagny et al.   CANCER RESEARCH

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Recent advances in inflammasome biology

(2018) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

Roles of mammalian glutathione peroxidase and thioredoxin reductase enzymes in the cellular response to nitrosative stress

(2018) Moran Benhar   FREE RADICAL BIOLOGY AND MEDICINE

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Oxeiptosis: a discreet way to respond to radicals

(2018) Pietro Scaturro et al.   CURRENT OPINION IN IMMUNOLOGY

Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis

(2017) Eduardo Reynoso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production bothin vitroand in a mouse model of inflammation

(2017) Mariela Castelblanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis

(2017) Shuzhen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

Targeting Thioredoxin-1 by dimethyl fumarate induces ripoptosome-mediated cell death

(2017) Anne Schroeder et al.   Scientific Reports

Protein oxidation and peroxidation

(2016) M. J. Davies   BIOCHEMICAL JOURNAL

Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance

(2016) Rotem Engelman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual targeting of the thioredoxin and glutathione systems in cancer and HIV

(2016) Moran Benhar et al.   JOURNAL OF CLINICAL INVESTIGATION

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype

(2016) Xianli Shen et al.   NATURE IMMUNOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State

(2016) Alessandra Folda et al.   Scientific Reports

Nitric oxide and the thioredoxin system: a complex interplay in redox regulation

(2015) Moran Benhar   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

RIP3 S-nitrosylation contributes to cerebral ischemic neuronal injury

(2015) Wanying Miao et al.   BRAIN RESEARCH

Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks

(2015) Neal S. Gould et al.   CHEMISTRY & BIOLOGY

ROS-dependent signal transduction

(2015) Colleen R Reczek et al.   CURRENT OPINION IN CELL BIOLOGY

The cysteine proteome

(2015) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melanoma Differentiation Associated Gene-7/Interleukin-24 Induces Caspase-3 Denitrosylation to Facilitate the Activation of Cancer Cell Apoptosis

(2015) Hui Tian et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

(2015) Paolo Bernardi et al.   PHYSIOLOGICAL REVIEWS

Nitric oxide synthase in innate and adaptive immunity: an update

(2015) Christian Bogdan   TRENDS IN IMMUNOLOGY

Regulation of cell death receptor S-nitrosylation and apoptotic signaling by Sorafenib in hepatoblastoma cells

(2015) A. Rodríguez-Hernández et al.   Redox Biology

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nitrosothiol signaling and protein nitrosation in cell death

(2014) Anand Krishnan V. Iyer et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Multilevel Regulation of 2-Cys Peroxiredoxin Reaction Cycle byS-Nitrosylation

(2013) Rotem Engelman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein oxidation in aging and the removal of oxidized proteins

(2013) Annika Höhn et al.   Journal of Proteomics

Selective Targeting of the Cysteine Proteome by Thioredoxin and Glutathione Redox Systems

(2013) Young-Mi Go et al.   MOLECULAR & CELLULAR PROTEOMICS

GluR6-FasL-Trx2 mediates denitrosylation and activation of procaspase-3 in cerebral ischemia/reperfusion in rats

(2013) N Sun et al.   Cell Death & Disease

Protein-Thiol Oxidation and Cell Death: Regulatory Role of Glutaredoxins

(2012) Erin M.G. Allen et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Efflux and Cell Death

(2012) Rodrigo Franco et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

(2012) E. Hernandez-Cuellar et al.   JOURNAL OF IMMUNOLOGY

Oxidative Processing of Latent Fas in the Endoplasmic Reticulum Controls the Strength of Apoptosis

(2012) V. Anathy et al.   MOLECULAR AND CELLULAR BIOLOGY

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

S-Nitrosylation of the Death Receptor Fas Promotes Fas Ligand–Mediated Apoptosis in Cancer Cells

(2011) Lissbeth Leon-Bollotte et al.   GASTROENTEROLOGY

Cysteine 203 of Cyclophilin D Is Critical for Cyclophilin D Activation of the Mitochondrial Permeability Transition Pore

(2011) Tiffany T. Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death

(2010) Tomohiro Nakamura et al.   MOLECULAR CELL

Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1

(2009) Yong Zuo et al.   CELL RESEARCH

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas

(2009) Vikas Anathy et al.   JOURNAL OF CELL BIOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Protein denitrosylation: enzymatic mechanisms and cellular functions

(2009) Moran Benhar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

(2009) A. H. K. Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of caspase-3 activity and activation by protein glutathionylation

(2008) Zhishan Huang et al.   BIOCHEMICAL PHARMACOLOGY

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

(2008) Yvonne M.W. Janssen-Heininger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to H2O2-induced Apoptosis

(2008) Chunlai Nie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IAPs: What's in a Name?

(2008) Srinivasa M. Srinivasula et al.   MOLECULAR CELL

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

Cytochrome c: functions beyond respiration

(2008) Yong-Ling P. Ow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulated Protein Denitrosylation by Cytosolic and Mitochondrial Thioredoxins

(2008) M. Benhar et al.   SCIENCE

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY