The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

(2020) Prakash Dharmalingam et al.   ACS Nano

Transcription factors in ferroptotic cell death

(2020) Chongshan Dai et al.   CANCER GENE THERAPY

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

(2020) Alexandr A. Kapralov et al.   Nature Chemical Biology

Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease

(2020) Nao Yan et al.   Frontiers in Neuroscience

Ferroptosis at the crossroads of infection, aging and cancer

(2020) Shinya Toyokuni et al.   CANCER SCIENCE

Optimized lactoferrin as a highly promising treatment for intracerebral hemorrhage: Pre-clinical experience

(2020) Xiurong Zhao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity

(2020) Paul W. Buehler et al.   TRENDS IN MOLECULAR MEDICINE

Ion Transport in Eryptosis, the Suicidal Death of Erythrocytes

(2020) Michael Föller et al.   Frontiers in Cell and Developmental Biology

Heme oxygenase-2 is post-translationally regulated by heme occupancy in the catalytic site

(2020) Liu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

(2019) Pengxu Lei et al.   Frontiers in Physiology

Pooled analysis suggests benefit of catheter-based hematoma removal for intracerebral hemorrhage

(2019) Pitchaiah Mandava et al.   NEUROLOGY

Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial

(2019) Magdy Selim et al.   LANCET NEUROLOGY

Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial

(2019) Daniel F Hanley et al.   LANCET

Industry corner: perspectives and controversies

(2019) C H Takimoto et al.   ANNALS OF ONCOLOGY

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

(2019) Shu-Wing Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhancement of Hematoma Clearance With CD47 Blocking Antibody in Experimental Intracerebral Hemorrhage

(2019) Chaohui Jing et al.   STROKE

Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm

(2019) Michael Hugelshofer et al.   JOURNAL OF CLINICAL INVESTIGATION

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

The macrophage heme-heme oxygenase-1 system and its role in inflammation

(2018) Vijith Vijayan et al.   BIOCHEMICAL PHARMACOLOGY

Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion

(2018) Lyla A. Youssef et al.   BLOOD

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

The role of Ca 2+ in cell death caused by oxidative glutamate toxicity and ferroptosis

(2018) Pamela Maher et al.   CELL CALCIUM

Pathological Roles of Iron in Cardiovascular Disease

(2018) Motoi Kobayashi et al.   CURRENT DRUG TARGETS

Labile iron pool as a parameter to monitor iron overload and oxidative stress status in β-thalassemic erythrocytes

(2018) Boonyanuch Chutvanichkul et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Identification of novel circulatory microRNA signatures linked to patients with ischemic stroke

(2018) Murali Vijayan et al.   HUMAN MOLECULAR GENETICS

Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis

(2018) Yuki Yamaguchi et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteomic Analysis of Cerebral Cortex Extracts from Sus scrofa with Induced Hemorrhagic Stroke

(2018) Alexander A. Sidyakin et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Haemoglobin scavenging in intracranial bleeding: biology and clinical implications

(2018) Diederik Bulters et al.   Nature Reviews Neurology

Injury mechanisms in acute intracerebral hemorrhage

(2018) D. Andrew Wilkinson et al.   NEUROPHARMACOLOGY

Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage

(2018) Xiurong Zhao et al.   STROKE

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

(2018) Eran Agmon et al.   Scientific Reports

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Early Hemolysis Within Human Intracerebral Hematomas: an MRI Study

(2018) Ran Liu et al.   Translational Stroke Research

Oxytosis/Ferroptosis—(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

(2018) Jan Lewerenz et al.   Frontiers in Neuroscience

Ultrastructural Characteristics of Neuronal Death and White Matter Injury in Mouse Brain Tissues After Intracerebral Hemorrhage: Coexistence of Ferroptosis, Autophagy, and Necrosis

(2018) Qian Li et al.   Frontiers in Neurology

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice

(2018) Bao-Shu Xie et al.   CNS Neuroscience & Therapeutics

Ascorbate and ferritin interactions: consequences for iron release in vitro and in vivo and implications for inflammation

(2018) Charles Badu-Boateng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

(2018) Mariapaola Nitti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Remote ischemic post-conditioning promotes hematoma resolution via AMPK-dependent immune regulation

(2018) Kumar Vaibhav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

Ferroptosis and Its Role in Diverse Brain Diseases

(2018) Abigail Weiland et al.   MOLECULAR NEUROBIOLOGY

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice

(2017) Qian Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Biomarkers of Functional Outcome in Intracerebral Hemorrhage: Interplay between Clinical Metrics, CD163, and Ferritin

(2017) Andrew L.A. Garton et al.   Journal of Stroke & Cerebrovascular Diseases

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Iron addiction: a novel therapeutic target in ovarian cancer

(2017) D Basuli et al.   ONCOGENE

CD163 Expression in Neurons After Experimental Intracerebral Hemorrhage

(2017) Ran Liu et al.   STROKE

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

Minocycline in Acute Cerebral Hemorrhage

(2017) Abdelrahman Y. Fouda et al.   STROKE

CD163, a Hemoglobin/Haptoglobin Scavenger Receptor, After Intracerebral Hemorrhage: Functions in Microglia/Macrophages Versus Neurons

(2017) Thomas Garton et al.   Translational Stroke Research

Biomarkers of Functional Outcome in Intracerebral Hemorrhage: Interplay between Clinical Metrics, CD163, and Ferritin

(2017) Andrew L.A. Garton et al.   Journal of Stroke & Cerebrovascular Diseases

Secondary Hematoma Expansion and Perihemorrhagic Edema after Intracerebral Hemorrhage: From Bench Work to Practical Aspects

(2017) Krista Lim-Hing et al.   Frontiers in Neurology

Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis

(2017) Inês B. Santarino et al.   Scientific Reports

Protein oxidation and peroxidation

(2016) M. J. Davies   BIOCHEMICAL JOURNAL

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Toll-Like Receptor 4/MyD88–Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral HemorrhageClinical Perspective

(2016) Xiao-Yi Xiong et al.   CIRCULATION

Stroke, Vascular Dementia, and Alzheimer’s Disease: Molecular Links

(2016) Murali Vijayan et al.   JOURNAL OF ALZHEIMERS DISEASE

Heme oxygenase-1 promotes neuron survival through down-regulation of neuronal NLRP1 expression after spinal cord injury

(2016) Wen-Ping Lin et al.   Journal of Neuroinflammation

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Perihematomal Edema Expansion Rates and Patient Outcomes in Deep and Lobar Intracerebral Hemorrhage

(2016) Zachary Grunwald et al.   Neurocritical Care

Isolation and Identification of Intermediates of the Oxidative Bilirubin Degradation

(2016) Marcel Ritter et al.   ORGANIC LETTERS

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

(2016) Xiaochun Duan et al.   Oxidative Medicine and Cellular Longevity

Heme–Hemopexin Scavenging Is Active in the Brain and Associates With Outcome After Subarachnoid Hemorrhage

(2016) Patrick Garland et al.   STROKE

Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage

(2016) Shenglong Cao et al.   STROKE

Differences in vulnerability of neurons and astrocytes to heme oxygenase-1 modulation: Implications for mitochondrial ferritin

(2016) Xiaojun Yu et al.   Scientific Reports

Early Erythrolysis in the Hematoma After Experimental Intracerebral Hemorrhage

(2016) Ge Dang et al.   Translational Stroke Research

Association of Cerebral Microbleeds With Cognitive Decline and Dementia

(2016) Saloua Akoudad et al.   JAMA Neurology

Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1

(2015) Nils Schallner et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Targeting secondary injury in intracerebral haemorrhage—perihaematomal oedema

(2015) Sebastian Urday et al.   Nature Reviews Neurology

Partial loss of the DNA repair scaffolding protein, Xrcc1 , results in increased brain damage and reduced recovery from ischemic stroke in mice

(2015) Somnath Ghosh et al.   NEUROBIOLOGY OF AGING

Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+NIK+signalosome on Rab5+endosomes

(2015) Dan Jane-wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders

(2015) Ann Smith et al.   Frontiers in Physiology

Heme oxygenase-1 and anti-inflammatory M2 macrophages

(2014) Yuji Naito et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Hemin inhibits the large conductance potassium channel in brain mitochondria: A putative novel mechanism of neurodegeneration

(2014) Bartłomiej Augustynek et al.   EXPERIMENTAL NEUROLOGY

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin

(2014) Todd L. Mollan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein/Protein Interactions in the Mammalian Heme Degradation Pathway

(2014) Andrea L. M. Spencer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD36-Mediated Hematoma Absorption following Intracerebral Hemorrhage: Negative Regulation by TLR4 Signaling

(2014) H. Fang et al.   JOURNAL OF IMMUNOLOGY

A Review on Hemeoxygenase-2: Focus on Cellular Protection and Oxygen Response

(2014) Jorge Muñoz-Sánchez et al.   Oxidative Medicine and Cellular Longevity

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication

(2014) Mohamed Ouzzine et al.   Frontiers in Cellular Neuroscience

Cerebral Microbleeds: A Review of Clinical, Genetic, and Neuroimaging Associations

(2014) Paul A. Yates et al.   Frontiers in Neurology

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

High Dose Deferoxamine in Intracerebral Hemorrhage (Hi-Def) Trial: Rationale, Design, and Methods

(2013) Sharon D. Yeatts et al.   Neurocritical Care

Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin

(2013) László Potor et al.   Oxidative Medicine and Cellular Longevity

Progress in translational research on intracerebral hemorrhage: Is there an end in sight?

(2013) Guohua Xi et al.   PROGRESS IN NEUROBIOLOGY

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Hemoglobin Redox Reactions and Red Blood Cell Aging

(2012) Joseph M. Rifkind et al.   ANTIOXIDANTS & REDOX SIGNALING

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Analyses of haptoglobin level in the cerebrospinal fluid and serum of patients with neuromyelitis optica and multiple sclerosis

(2012) Kuo-Hsuan Chang et al.   CLINICA CHIMICA ACTA

Antioxidant Therapy: Current Status and Future Prospects

(2012) O. Firuzi et al.   CURRENT MEDICINAL CHEMISTRY

The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage

(2012) James Galea et al.   JOURNAL OF NEUROCHEMISTRY

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

(2012) Sen Lin et al.   Journal of Neuroinflammation

Hemopexin decreases hemin accumulation and catabolism by neural cells

(2012) Jing Chen-Roetling et al.   NEUROCHEMISTRY INTERNATIONAL

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Glutathione: a key component of the cytoplasmic labile iron pool

(2011) Robert C. Hider et al.   BIOMETALS

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

(2011) Ya-Min Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prophylactic neuroprotection against stroke: Low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function

(2011) Yanxin Zhao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

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(2011) Theresa N. Dang et al.   NEUROCHEMISTRY INTERNATIONAL

Molecular Pathophysiology of Cerebral Hemorrhage

(2011) Jaroslaw Aronowski et al.   STROKE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Nature of the Ferryl Heme in Compounds I and II

(2010) Andrea Gumiero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unconjugated Bilirubin Contributes to Early Inflammation and Edema after Intracerebral Hemorrhage

(2010) Matthew C Loftspring et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Accelerated hemolysis and neurotoxicity in neuron-glia-blood clot co-cultures

(2010) Kellie M. Jaremko et al.   JOURNAL OF NEUROCHEMISTRY

Heme Oxygenase Reveals Its Strategy for Catalyzing Three Successive Oxygenation Reactions

(2009) Toshitaka Matsui et al.   ACCOUNTS OF CHEMICAL RESEARCH

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin

(2009) Theresa N. Dang et al.   GLIA

Neuroprotective Role of Haptoglobin after Intracerebral Hemorrhage

(2009) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

A novel brain injury mechanism after intracerebral hemorrhage: The interaction between heme products and the immune system

(2009) Matthew C. Loftspring et al.   MEDICAL HYPOTHESES

Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke

(2009) Stephen R. Robinson et al.   REDOX REPORT

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling

Effects of Deferoxamine on Intracerebral Hemorrhage-Induced Brain Injury in Aged Rats

(2009) Masanobu Okauchi et al.   STROKE

Deferoxamine Reduces Intracerebral Hematoma-Induced Iron Accumulation and Neuronal Death in Piglets

(2009) Yuxiang Gu et al.   STROKE

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Erythrocyte programmed cell death

(2008) Michael Föller et al.   IUBMB LIFE

Imaging of intracranial haemorrhage

(2008) Chelsea S Kidwell et al.   LANCET NEUROLOGY