Haemoglobin scavenging in intracranial bleeding: biology and clinical implications

CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis

(2018) Liang Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study

(2018) James Galea et al.   JOURNAL OF NEUROSURGERY

A rare splice donor mutation in the haptoglobin gene associates with blood lipid levels and coronary artery disease

(2017) Eythor Bjornsson et al.   HUMAN MOLECULAR GENETICS

The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes

(2017) Jenna L Leclerc et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage

(2017) Jing Chen-Roetling et al.   NEUROBIOLOGY OF DISEASE

Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis

(2017) Ben Gaastra et al.   Oxidative Medicine and Cellular Longevity

CD163 Expression in Neurons After Experimental Intracerebral Hemorrhage

(2017) Ran Liu et al.   STROKE

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

Sulforaphane activates the cerebral vascular Nrf2–ARE pathway and suppresses inflammation to attenuate cerebral vasospasm in rat with subarachnoid hemorrhage

(2016) Xudong Zhao et al.   BRAIN RESEARCH

Microparticle derived proteins as potential biomarkers for cerebral vasospasm post subarachnoid hemorrhage. A preliminary study

(2016) Magdalena M. Przybycien-Szymanska et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Activation of the NLRP3 inflammasome by cellular labile iron

(2016) Kyohei Nakamura et al.   EXPERIMENTAL HEMATOLOGY

Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage

(2016) Jenna L Leclerc et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old mice

(2016) Zhen Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Low-density lipoprotein receptor-related protein-1 facilitates heme scavenging after intracerebral hemorrhage in mice

(2016) Gaiqing Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Haptoglobin increases the vulnerability of CD163-expressing neurons to hemoglobin

(2016) Jing Chen-Roetling et al.   JOURNAL OF NEUROCHEMISTRY

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage

(2016) Bo Ma et al.   Journal of Neuroinflammation

A reactivity-based probe of the intracellular labile ferrous iron pool

(2016) Benjamin Spangler et al.   Nature Chemical Biology

CD163 promotes hematoma absorption and improves neurological functions in patients with intracerebral hemorrhage

(2016) Qun Liu et al.   Neural Regeneration Research

Haptoglobin 2-2 Genotype Is Associated With Cerebral Salt Wasting Syndrome in Aneurysmal Subarachnoid Hemorrhage

(2016) Santosh B. Murthy et al.   NEUROSURGERY

Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage

(2016) Shenglong Cao et al.   STROKE

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

(2015) Yang Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage

(2015) Min Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intraventricular Fibrinolysis with Tissue Plasminogen Activator is Associated with Transient Cerebrospinal Fluid Inflammation: A Randomized Controlled Trial

(2015) Andreas H Kramer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1

(2015) Nils Schallner et al.   JOURNAL OF CLINICAL INVESTIGATION

CD163/Hemoglobin Oxygenase-1 Pathway Regulates Inflammation in Hematoma Surrounding Tissues after Intracerebral Hemorrhage

(2015) BaoHua Liu et al.   Journal of Stroke & Cerebrovascular Diseases

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

(2015)   LANCET

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome

(2015) Anwen Shao et al.   MOLECULAR NEUROBIOLOGY

Targeting secondary injury in intracerebral haemorrhage—perihaematomal oedema

(2015) Sebastian Urday et al.   Nature Reviews Neurology

Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage

(2015) Jenna L. Leclerc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte Overexpression of Heme Oxygenase-1 Improves Outcome After Intracerebral Hemorrhage

(2015) J. Chen-Roetling et al.   STROKE

Presence of Haptoglobin-2 Allele Is Associated with Worse Functional Outcomes After Spontaneous Intracerebral Hemorrhage

(2015) Santosh B. Murthy et al.   World Neurosurgery

CD163/Hemoglobin Oxygenase-1 Pathway Regulates Inflammation in Hematoma Surrounding Tissues after Intracerebral Hemorrhage

(2015) BaoHua Liu et al.   Journal of Stroke & Cerebrovascular Diseases

Pleiotropic Role of PPARγin Intracerebral Hemorrhage: An Intricate System Involving Nrf2, RXR, and NF-κB

(2014) Xiu-Rong Zhao et al.   CNS Neuroscience & Therapeutics

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin

(2014) Todd L. Mollan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance

(2014) Xiurong Zhao et al.   JOURNAL OF NEUROCHEMISTRY

Prognostic value of intrathecal heme oxygenase–1 concentration in patients with Fisher Grade III aneurysmal subarachnoid hemorrhage

(2014) Kuo-Chuan Wang et al.   JOURNAL OF NEUROSURGERY

Macrophage subsets in atherosclerosis

(2014) Giulia Chinetti-Gbaguidi et al.   Nature Reviews Cardiology

Rosiglitazone Attenuates Cerebral Vasospasm and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage

(2014) Bo-Feng Lin et al.   Neurocritical Care

Hemolysis-induced lethality involves inflammasome activation by heme

(2014) Fabianno F. Dutra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine β145

(2013) Chris E. Cooper et al.   ANTIOXIDANTS & REDOX SIGNALING

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

(2013) Miriam Lipiski et al.   ANTIOXIDANTS & REDOX SIGNALING

Time course of Keap1-Nrf2 pathway expression after experimental intracerebral haemorrhage: correlation with brain oedema and neurological deficit

(2013) H. Shang et al.   FREE RADICAL RESEARCH

Sulforaphane enhances the activity of the Nrf2–ARE pathway and attenuates inflammation in OxyHb-induced rat vascular smooth muscle cells

(2013) X.-D. Zhao et al.   INFLAMMATION RESEARCH

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms

(2013) K. Subramanian et al.   JOURNAL OF IMMUNOLOGY

Safety and pharmacokinetics of sodium nitrite in patients with subarachnoid hemorrhage: a Phase IIA study

(2013) Edward H. Oldfield et al.   JOURNAL OF NEUROSURGERY

Haptoglobin genotype and functional outcome after aneurysmal subarachnoid hemorrhage

(2013) Ellen Kantor et al.   JOURNAL OF NEUROSURGERY

Haptoglobin Phenotype Predicts Cerebral Vasospasm and Clinical Deterioration after Aneurysmal Subarachnoid Hemorrhage

(2013) Hiroyuki Ohnishi et al.   Journal of Stroke & Cerebrovascular Diseases

Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial

(2013) A David Mendelow et al.   LANCET

High Dose Deferoxamine in Intracerebral Hemorrhage (Hi-Def) Trial: Rationale, Design, and Methods

(2013) Sharon D. Yeatts et al.   Neurocritical Care

NRF2-regulation in brain health and disease: Implication of cerebral inflammation

(2013) Mats Sandberg et al.   NEUROPHARMACOLOGY

Lesional accumulation of heme oxygenase-1+ microglia/macrophages in rat traumatic brain injury

(2013) Yuqi Liu et al.   NEUROREPORT

Prospective, Randomized, Open-Label Phase II Trial on Concomitant Intraventricular Fibrinolysis and Low-Frequency Rotation After Severe Subarachnoid Hemorrhage

(2013) N. Etminan et al.   STROKE

Minimally Invasive Surgery Plus Recombinant Tissue-type Plasminogen Activator for Intracerebral Hemorrhage Evacuation Decreases Perihematomal Edema

(2013) W. Andrew Mould et al.   STROKE

Current Management of Delayed Cerebral Ischemia: Update from Results of Recent Clinical Trials

(2013) Shakira Brathwaite et al.   Translational Stroke Research

Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer’s disease

(2013) Roxana Carare et al.   Acta Neuropathologica Communications

Plasma Clearance of Hemoglobin and Haptoglobin in Mice and Effect of CD163 Gene Targeting Disruption

(2012) Anders Etzerodt et al.   ANTIOXIDANTS & REDOX SIGNALING

Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury

(2012) Zhiren Zhang et al.   BRAIN RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

(2012) A. D. Greenhalgh et al.   Disease Models & Mechanisms

Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions

(2012) Sambuddha Banerjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Design of a Prospective, Dose-Escalation Study Evaluating the Safety of Pioglitazone for Hematoma Resolution in Intracerebral Hemorrhage (SHRINC)

(2012) Nicole R. Gonzales et al.   International Journal of Stroke

The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage

(2012) James Galea et al.   JOURNAL OF NEUROCHEMISTRY

Elevated serum haptoglobin after traumatic brain injury is synthesized mainly in liver

(2012) Shuguang Yang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

(2012) Richard F Keep et al.   LANCET NEUROLOGY

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Lumbar Drainage of Cerebrospinal Fluid After Aneurysmal Subarachnoid Hemorrhage

(2012) Yahia Z. Al-Tamimi et al.   STROKE

Heterogenous distribution of ferroportin-containing neurons in mouse brain

(2011) Michael W. Boserup et al.   BIOMETALS

Activating Transcription Factor 1 Directs Mhem Atheroprotective Macrophages Through Coordinated Iron Handling and Foam Cell Protection

(2011) Joseph J. Boyle et al.   CIRCULATION RESEARCH

Experimental Subarachnoid Hemorrhage Causes Early and Long-Lasting Microarterial Constriction and Microthrombosis: An in-vivo Microscopy Study

(2011) Benjamin Friedrich et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage

(2011) Gang Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Method of Aneurysm Treatment Does Not Affect Clot Clearance After Aneurysmal Subarachnoid Hemorrhage

(2011) George M. Ibrahim et al.   NEUROSURGERY

Safety and Tolerability of Deferoxamine Mesylate in Patients With Acute Intracerebral Hemorrhage

(2011) Magdy Selim et al.   STROKE

Pilot Safety Trial of Deferiprone in 10 Subjects With Superficial Siderosis

(2011) Michael Levy et al.   STROKE

EARLYDRAIN- outcome after early lumbar CSF-drainage in aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial

(2011) Jürgen Bardutzky et al.   Trials

Time course of heme oxygenase-1 and oxidative stress after experimental intracerebral hemorrhage

(2010) Gaiqing Wang et al.   ACTA NEUROCHIRURGICA

Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice

(2010) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heme Oxygenase-2 Modulates Early Pathogenesis after Traumatic Injury to the Immature Brain

(2010) Tomoko Yoneyama-Sarnecky et al.   DEVELOPMENTAL NEUROSCIENCE

Kinetics and Specificity of Feline Leukemia Virus Subgroup C Receptor (FLVCR) Export Function and Its Dependence on Hemopexin

(2010) Zhantao Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemoglobin-Induced Oxidative Stress Contributes to Matrix Metalloproteinase Activation and Blood–Brain Barrier Dysfunction in vivo

(2010) Masataka Katsu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Intravenous Anakinra can Achieve Experimentally Effective Concentrations in the Central Nervous System within a Therapeutic Time Window: Results of a Dose-Ranging Study

(2010) James Galea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Uncoupling of Endothelial Nitric Oxide Synthase after Experimental Subarachnoid Hemorrhage

(2010) Mohammed Sabri et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice

(2010) Lifen Chen et al.   JOURNAL OF NEUROSURGERY

Quantitative Mass Spectrometry Defines an Oxidative Hotspot in Hemoglobin that is Specifically Protected by Haptoglobin

(2010) Tatiana Pimenova et al.   JOURNAL OF PROTEOME RESEARCH

Cerebrospinal Fluid Ferritin Level, a Sensitive Diagnostic Test in Late-Presenting Subarachnoid Hemorrhage

(2010) Axel Petzold et al.   Journal of Stroke & Cerebrovascular Diseases

Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development

(2010) E Mosconi et al.   Mucosal Immunology

Locally-administered Intrathecal Thrombolytics Following Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis

(2010) Andreas H. Kramer et al.   Neurocritical Care

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Haptoglobin phenotype and apolipoprotein E polymorphism: Relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injury

(2009) Gail D. Anderson et al.   EPILEPSY & BEHAVIOR

Neuroprotective Role of Haptoglobin after Intracerebral Hemorrhage

(2009) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Anti-haptoglobin antibody detection after febrile non-hemolytic transfusion reactions in a non-haptoglobin-deficient patient

(2009) Tsuyoshi Muta et al.   TRANSFUSION AND APHERESIS SCIENCE

A Multimodal Concept in Patients after Severe Aneurysmal Subarachnoid Hemorrhage: Results of a Controlled Single Centre Prospective Randomized Multimodal Phase I/II Trial on Cerebral Vasospasm

(2009) D. Hänggi et al.   Central European neurosurgery

The pathology of superficial siderosis of the central nervous system

(2008) Arnulf H. Koeppen et al.   ACTA NEUROPATHOLOGICA

The reaction of hydrogen peroxide with hemoglobin induces extensive α-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways

(2008) Florence Vallelian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage

(2008) J. Wang et al.   NEUROSCIENCE

Nitric Oxide Modulates Spreading Depolarization Threshold in the Human and Rodent Cortex

(2008) Gabor C. Petzold et al.   STROKE

Intracellular labile iron

(2007) William Breuer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY