The muscle to bone axis (and viceversa): An encrypted language affecting tissues and organs and yet to be codified?

Calcium supplements: Good for the bone, bad for the heart? A systematic updated appraisal

(2020) Marco B. Morelli et al.   ATHEROSCLEROSIS

Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression

(2020) Zhihao Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease

(2020) Vincenzo Musolino et al.   Scientific Reports

The Efficacy and Safety of Ipriflavone in Postmenopausal Women with Osteopenia or Osteoporosis: A Systematic Review and Meta-analysis

(2020) Qinsheng Hu et al.   PHARMACOLOGICAL RESEARCH

Exercising your fat (metabolism) into shape: a muscle-centred view

(2020) Anne Gemmink et al.   DIABETOLOGIA

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

(2020) Eben G Estell et al.   eLife

Muscle, Bone, and Fat Crosstalk: the Biological Role of Myokines, Osteokines, and Adipokines

(2020) Ben Kirk et al.   Current Osteoporosis Reports

Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets

(2020) Shingo Takada et al.   Frontiers in Cardiovascular Medicine

Early rehabilitation in older patients hospitalized with acute decompensated heart failure: A retrospective cohort study

(2020) Shiho Takada et al.   AMERICAN HEART JOURNAL

CKD autophagy activation and skeletal muscle atrophy—a preliminary study of mitophagy and inflammation

(2019) Yue yue Zhang et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

(2019) Bumsoo Ahn et al.   Journal of Cachexia Sarcopenia and Muscle

FGF23, Biomarker or Target?

(2019) Cristian Rodelo-Haad et al.   Toxins

Mechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible Therapeutic Measures

(2019) María Rubio-Ruiz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sarcopenia: revised European consensus on definition and diagnosis

(2019) Alfonso J Cruz-Jentoft et al.   AGE AND AGEING

The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications

(2019) Jessica Maiuolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis

(2019) GuoBin Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The role of the fibroblast growth factor family in bone‐related diseases

(2019) Jicheng Wang et al.   Chemical Biology & Drug Design

Epigenetic regulation of bone remodeling by natural compounds

(2019) Nishikant Raut et al.   PHARMACOLOGICAL RESEARCH

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk

(2019) Jiao Wu et al.   Journal of Cachexia Sarcopenia and Muscle

Neuromuscular Junction as an Entity of Nerve-Muscle Communication

(2019) Elisa Lepore et al.   Cells

Updated concept of sarcopenia based on muscle–bone relationship

(2019) Mitsutaka Yakabe et al.   JOURNAL OF BONE AND MINERAL METABOLISM

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

Skeletal muscle wasting in chronic kidney disease: the emerging role of microRNAs

(2019) Kate A Robinson et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality

(2019) Flavia G. De Carvalho et al.   Nutrients

Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis

(2019) Gregory Livshits et al.   AGEING RESEARCH REVIEWS

Bone turnover: Biology and assessment tools

(2018) Pawel Szulc   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Osteosarcopenia

(2018) James Paintin et al.   BRITISH JOURNAL OF HOSPITAL MEDICINE

More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases

(2018) Mathieu Buonafine et al.   CLINICAL SCIENCE

The emerging role of follistatin under stresses and its implications in diseases

(2018) Lingda Zhang et al.   GENE

A Complex Role for Lipocalin 2 in Bone Metabolism: Global Ablation in Mice Induces Osteopenia Caused by an Altered Energy Metabolism

(2018) Mattia Capulli et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteosarcopenia in Patients with Hip Fracture Is Related with High Mortality

(2018) Jun-Il Yoo et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and c-kit pos CD45 neg CD31 neg cardiac stem cell activation

(2018) Cristina Carresi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mineral and bone disorders in chronic heart failure

(2018) E. V. Reznik et al.   KARDIOLOGIYA

Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse

(2018) T. Bettis et al.   OSTEOPOROSIS INTERNATIONAL

β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

(2018) Yukiko Kitase et al.   Cell Reports

miRNA-23a/27a attenuates muscle atrophy and renal fibrosis through muscle-kidney crosstalk

(2018) Aiqing Zhang et al.   Journal of Cachexia Sarcopenia and Muscle

Sarcopenia and risk of nonalcoholic fatty liver disease: A meta-analysis

(2018) Karn Wijarnpreecha et al.   Saudi Journal of Gastroenterology

Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity

(2018) Kelsey H. Collins et al.   Frontiers in Physiology

Physiological Actions of Fibroblast Growth Factor-23

(2018) Reinhold G. Erben   Frontiers in Endocrinology

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

(2018) Xingxing Kong et al.   Cell Metabolism

Sarcopenia Contributes to the Progression of Nonalcoholic Fatty Liver Disease- Related Fibrosis: A Meta-Analysis

(2018) Xiaoyan Pan et al.   DIGESTIVE DISEASES

STAT3 in Skeletal Muscle Function and Disorders

(2018) Eleonora Guadagnin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/β-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures

(2018) Arturo Pujia et al.   Nutrients

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2018) Hyeonwoo Kim et al.   CELL

Use it or lose it to age: A review of bone and muscle communication

(2018) Lynda Bonewald   BONE

Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics

(2017) Anna Chiara Nascimbeni et al.   FEBS Journal

Myostatin signaling is up-regulated in female patients with advanced heart failure

(2017) Junichi Ishida et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Blocking of the Ubiquitin-Proteasome System Prevents Inflammation-Induced Bone Loss by Accelerating M-CSF Receptor c-Fms Degradation in Osteoclast Differentiation

(2017) Kyunghee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication

(2017) Yiwen Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Muscle-Adipose Tissue Cross Talk

(2017) Kristin I. Stanford et al.   Cold Spring Harbor Perspectives in Medicine

Bone Mineral Density and Risk of Heart Failure in Older Adults: The Cardiovascular Health Study

(2017) Raymond B. Fohtung et al.   Journal of the American Heart Association

Muscle wasting in young patients with dilated cardiomyopathy

(2017) Marjan Hajahmadi et al.   Journal of Cachexia Sarcopenia and Muscle

Bone Quality in Chronic Kidney Disease: Definitions and Diagnostics

(2017) Erin M. B. McNerny et al.   Current Osteoporosis Reports

Locally Produced BDNF Promotes Sclerotic Change in Alveolar Bone after Nerve Injury

(2017) Hiroko Ida-Yonemochi et al.   PLoS One

Sarcopenia is associated with severe liver fibrosis in patients with non-alcoholic fatty liver disease

(2016) S. Petta et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Immobilization and long-term recovery results in large changes in bone structure and strength but no corresponding alterations of osteocyte lacunar properties

(2016) Fiona Linnea Bach-Gansmo et al.   BONE

Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism

(2016) Baosheng Guo et al.   CALCIFIED TISSUE INTERNATIONAL

Nerve Growth Factor Promotes Angiogenesis and Skeletal Muscle Fiber Remodeling in a Murine Model of Hindlimb Ischemia

(2016) Yong-Jun Li et al.   CHINESE MEDICAL JOURNAL

Disrupted autophagy undermines skeletal muscle adaptation and integrity

(2016) Elliot J. Jokl et al.   MAMMALIAN GENOME

Muscle-bone interactions: From experimental models to the clinic? A critical update

(2016) Michaël R. Laurent et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

E3 ubiquitin ligases as novel targets for inflammatory diseases

(2016) Santosh Kumar Goru et al.   PHARMACOLOGICAL RESEARCH

Irisin promotes osteoblast proliferation and differentiation via activating the MAP kinase signaling pathways

(2016) Xiaoyong Qiao et al.   Scientific Reports

Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation

(2016) Vincenzo Musolino et al.   Journal of Cachexia Sarcopenia and Muscle

The beneficial role of proteolysis in skeletal muscle growth and stress adaptation

(2016) Ryan A. V. Bell et al.   Skeletal Muscle

Role of autophagy in bone and muscle biology

(2016) Maria Teresa Valenti et al.   World Journal of Stem Cells

Effects of Treatment of Treadmill Combined with Electro-Acupuncture on Tibia Bone Mass and Substance PExpression of Rabbits with Sciatic Nerve Injury

(2016) Yan Wang et al.   PLoS One

Sarcopenia – The search for emerging biomarkers

(2015) Alexander Kalinkovich et al.   AGEING RESEARCH REVIEWS

Muscle and bone, two interconnected tissues

(2015) Camille Tagliaferri et al.   AGEING RESEARCH REVIEWS

Role of IGF-I signaling in muscle bone interactions

(2015) Daniel D. Bikle et al.   BONE

Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity

(2015) Vanessa Pellegrinelli et al.   DIABETES

The “Mechanostat Theory” of Frost and the OPG/RANKL/RANK System

(2015) Joanna B. Tyrovola et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interactions Between Muscle Tissues and Bone Metabolism

(2015) Naoyuki Kawao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phenotype of Osteosarcopenia in Older Individuals With a History of Falling

(2015) Ya Ruth Huo et al.   Journal of the American Medical Directors Association

Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice

(2015) Berno Dankbar et al.   NATURE MEDICINE

Emerging molecules in the interface between skeletal system and innate immunity

(2015) Kenta Maruyama et al.   PHARMACOLOGICAL RESEARCH

Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action

(2015) Vikas Dutt et al.   PHARMACOLOGICAL RESEARCH

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

(2014) Sue C. Bodine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids

(2014) Mayurbhai Himatbhai Sahani et al.   Autophagy

Alcohol-induced autophagy contributes to loss in skeletal muscle mass

(2014) Samjhana Thapaliya et al.   Autophagy

Autophagy in osteoblasts is involved in mineralization and bone homeostasis

(2014) Marie Nollet et al.   Autophagy

The Rise and Fall of NGAL in Acute Kidney Injury

(2014) Johan Mårtensson et al.   BLOOD PURIFICATION

Skeletal Muscle: A Brief Review of Structure and Function

(2014) Walter R. Frontera et al.   CALCIFIED TISSUE INTERNATIONAL

IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α

(2014) Xingxing Kong et al.   CELL

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways

(2014) J. Rodriguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Postoperative Prevention of Falls in Older Adults with Fragility Fractures

(2014) Oddom Demontiero et al.   CLINICS IN GERIATRIC MEDICINE

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

(2014) A Rodríguez et al.   INTERNATIONAL JOURNAL OF OBESITY

Autophagy dysregulation in cell culture and animals models of spinal muscular atrophy

(2014) Sara K. Custer et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

(2014) Guo-Xiao Wang et al.   NATURE MEDICINE

The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: Role in nitrate tolerance

(2014) Vincenzo Mollace et al.   PHARMACOLOGICAL RESEARCH

Can Antioxidants Protect Against Disuse Muscle Atrophy?

(2014) Scott K. Powers   SPORTS MEDICINE

Irisin Enhances Osteoblast DifferentiationIn Vitro

(2014) Graziana Colaianni et al.   International Journal of Endocrinology

Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014

(2014) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Osteosarcopenic obesity: the role of bone, muscle, and fat on health

(2014) Michael J. Ormsbee et al.   Journal of Cachexia Sarcopenia and Muscle

Evidence for an Interaction Between Exercise and Nutrition for Improving Bone and Muscle Health

(2014) Robin M. Daly et al.   Current Osteoporosis Reports

Therapies for Musculoskeletal Disease: Can we Treat Two Birds with One Stone?

(2014) Christian M. Girgis et al.   Current Osteoporosis Reports

Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia

(2013) Fabio Penna et al.   AMERICAN JOURNAL OF PATHOLOGY

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Prognostic Value of Plasma Neutrophil Gelatinase–Associated Lipocalin for Mortality in Patients With Heart Failure

(2013) Vincent M. van Deursen et al.   Circulation-Heart Failure

Fibroblast Growth Factor 23 and Cardiovascular Mortality after Kidney Transplantation

(2013) L. C. Baia et al.   Clinical Journal of the American Society of Nephrology

Linkage between muscle and bone

(2013) Hiroshi Kaji   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Bone and Skeletal Muscle: Neighbors With Close Ties

(2013) Douglas J DiGirolamo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies

(2013) M. Sandri et al.   JOURNAL OF CELL SCIENCE

New insights into osteoporosis: the bone-fat connection

(2013) M. Kawai et al.   JOURNAL OF INTERNAL MEDICINE

NF-κB signaling and bone resorption

(2013) Y. Abu-Amer   OSTEOPOROSIS INTERNATIONAL

Standardising the descriptive epidemiology of osteoporosis: recommendations from the Epidemiology and Quality of Life Working Group of IOF

(2013) J. A. Kanis et al.   OSTEOPOROSIS INTERNATIONAL

Skeletal muscle autophagy: a new metabolic regulator

(2013) Brian A. Neel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanical Signaling for Bone Modeling and Remodeling

(2012) Alexander G. Robling et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

TWEAK and TRAF6 regulate skeletal muscle atrophy

(2012) Ashok Kumar et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486

(2012) Jing Xu et al.   KIDNEY INTERNATIONAL

The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

(2012) P. K. Paul et al.   MOLECULAR AND CELLULAR BIOLOGY

Chaperones in autophagy

(2012) Susmita Kaushik et al.   PHARMACOLOGICAL RESEARCH

MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

(2011) Michael S. Lustgarten et al.   AGING CELL

Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks

(2011) Simon S. Wing et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy

(2011) Jinze Xu et al.   EXPERIMENTAL GERONTOLOGY

Trabecular and cortical bone density and architecture in women after 60 days of bed rest using high-resolution pQCT: WISE 2005

(2011) Gabriele Armbrecht et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Vitamin D Status Is Associated With Arterial Stiffness and Vascular Dysfunction in Healthy Humans

(2011) Ibhar Al Mheid et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Erk1 Positively Regulates Osteoclast Differentiation and Bone Resorptive Activity

(2011) Yongzheng He et al.   PLoS One

Cancer Causes Cardiac Atrophy and Autophagy in a Sexually Dimorphic Manner

(2010) P. F. Cosper et al.   CANCER RESEARCH

PGC1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss

(2010) Wei Wei et al.   Cell Metabolism

Genetic Deletion of Myostatin From the Heart Prevents Skeletal Muscle Atrophy in Heart Failure

(2010) Joerg Heineke et al.   CIRCULATION

Anabolic and catabolic pathways regulating skeletal muscle mass

(2010) John J McCarthy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2

(2010) S. Lieu et al.   Disease Models & Mechanisms

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Exercise-induced oxidative stress in humans: Cause and consequences

(2010) Scott K. Powers et al.   FREE RADICAL BIOLOGY AND MEDICINE

Osteopontin deposition in remodeling bone: An osteoblast mediated event

(2010) Marc D. McKee et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inflammaging: The driving force in osteoporosis?

(2010) P. Lencel et al.   MEDICAL HYPOTHESES

Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity

(2009) Michael S. Lustgarten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

(2009) Margaret E. Benny Klimek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases

(2009) Rodolfo Gomez et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Fat targets for skeletal health

(2009) Masanobu Kawai et al.   Nature Reviews Rheumatology

Normal Bone Anatomy and Physiology

(2008) B. Clarke   Clinical Journal of the American Society of Nephrology

Osteocytes in the pathogenesis of osteoporosis

(2008) Kyoji Ikeda   Geriatrics & Gerontology International

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

(2008) Orlando M. Gutiérrez et al.   NEW ENGLAND JOURNAL OF MEDICINE