Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Characterization of the metabolic effects of irisin on skeletal musclein vitro

(2014) R. A. Vaughan et al.   DIABETES OBESITY & METABOLISM

Implication of Circulating Irisin Levels with Brown Adipose Tissue and Sarcopenia in Humans

(2014) Hae Yoon Choi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel Molecular Aspects of Ghrelin and Leptin in the Control of Adipobiology and the Cardiovascular System

(2014) Amaia Rodríguez   Obesity Facts

Irisin and exercise training in humans – Results from a randomized controlled training trial

(2013) Anne Hecksteden et al.   BMC Medicine

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans

(2013) Maria T Vamvini et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

(2013) Tizhong Shan et al.   FASEB JOURNAL

The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans

(2013) Frode Norheim et al.   FEBS Journal

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

(2013) José María Moreno-Navarrete et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effects of obesity, diabetes and exercise onFndc5gene expression and irisin release in human skeletal muscle and adipose tissue:in vivoandin vitrostudies

(2013) Timea Kurdiova et al.   JOURNAL OF PHYSIOLOGY-LONDON

Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats

(2013) Michael D. Roberts et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

Irisin, the metabolic syndrome and follistatin in humans

(2013) Pontus A. Boström et al.   Nature Reviews Endocrinology

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

(2013) Arturo Roca-Rivada et al.   PLoS One

Effects of Lipid-Lowering Drugs on Irisin in Human Subjects In Vivo and in Human Skeletal Muscle Cells Ex Vivo

(2013) Ioanna Gouni-Berthold et al.   PLoS One

Absence of Functional Leptin Receptor Isoforms in the POUND (Leprdb/lb) Mouse Is Associated with Muscle Atrophy and Altered Myoblast Proliferation and Differentiation

(2013) Phonepasong Arounleut et al.   PLoS One

Irisin and FNDC5 in retrospect

(2013) Harold P Erickson   Adipocyte

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Myonectin (CTRP15), a Novel Myokine That Links Skeletal Muscle to Systemic Lipid Homeostasis

(2012) Marcus M. Seldin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis

(2012) Saurabh Chatterjee et al.   JOURNAL OF HEPATOLOGY

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

(2012) M.-S. Hashemi et al.   NEUROSCIENCE

Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines

(2012) Naveen Sharma et al.   Nutrition & Metabolism

Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index

(2012) Andreas Stengel et al.   PEPTIDES

Transcriptional analysis of brown adipose tissue in leptin-deficient mice lacking inducible nitric oxide synthase: evidence of the role of Med1 in energy balance

(2012) Sara Becerril et al.   PHYSIOLOGICAL GENOMICS

Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines

(2012) Marcus M. Seldin et al.   Adipocyte

Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis

(2011) Thomas Braun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Abnormally decreased NO and augmented CO production in islets of the leptin-deficient ob/ob mouse might contribute to explain hyperinsulinemia and islet survival in leptin-resistant type 2 obese diabetes

(2011) Javier Jimenez-Feltstrom et al.   REGULATORY PEPTIDES

Impaired Muscle Regeneration in Ob/ob and Db/db Mice

(2011) Mai-Huong Nguyen et al.   TheScientificWorldJOURNAL

Myogenin and Class II HDACs Control Neurogenic Muscle Atrophy by Inducing E3 Ubiquitin Ligases

(2010) Viviana Moresi et al.   CELL

Deletion of Inducible Nitric-Oxide Synthase in Leptin-Deficient Mice Improves Brown Adipose Tissue Function

(2010) Sara Becerril et al.   PLoS One

Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes

(2009) A Rodríguez et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice

(2009) Neira Sáinz et al.   PLoS One

PRDM16: the interconvertible adipo-myocyte switch

(2009) Gema Frühbeck et al.   TRENDS IN CELL BIOLOGY

The role of exercise and PGC1α in inflammation and chronic disease

(2008) Christoph Handschin et al.   NATURE

Gender Dimorphism in Skeletal Muscle Leptin Receptors, Serum Leptin and Insulin Sensitivity

(2008) Borja Guerra et al.   PLoS One