Mechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible Therapeutic Measures

Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study

(2018) Gyuri Kim et al.   Cardiovascular Diabetology

Quercetin Reduces Tumor Necrosis Factor Alpha-Induced Muscle Atrophy by Upregulation of Heme Oxygenase-1

(2018) Yeji Kim et al.   JOURNAL OF MEDICINAL FOOD

Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies

(2018) John A. Batsis et al.   Nature Reviews Endocrinology

TNF-α and cancer cachexia: Molecular insights and clinical implications

(2017) Hetal J. Patel et al.   LIFE SCIENCES

Sarcopenia in patients (pts) with hepatocelluar carcinoma (HCC).

(2017) J. Meza-Junco et al.   JOURNAL OF CLINICAL ONCOLOGY

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation

(2016) Johanna Ábrigo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sarcopenia associated with renal function in the patients with type 2 diabetes

(2016) Rongrong Yang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas

(2016) María Gabriela Morales et al.   Disease Models & Mechanisms

Insulin resistance and sarcopenia: mechanistic links between common co-morbidities

(2016) Mark E Cleasby et al.   JOURNAL OF ENDOCRINOLOGY

Oral Drugs Related with Muscle Wasting and Sarcopenia. A Review

(2016) Lluis Campins et al.   PHARMACOLOGY

Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes

(2016) Hiroyasu Mori et al.   Journal of Diabetes Investigation

Alcohol consumption as a risk factor for sarcopenia - a meta-analysis

(2016) Michal Steffl et al.   BMC Geriatrics

Dietary protein intake in sarcopenic obese older women

(2016) Espedita Muscariello et al.   Clinical Interventions in Aging

Heavy Alcohol Consumption with Alcoholic Liver Disease Accelerates Sarcopenia in Elderly Korean Males: The Korean National Health and Nutrition Examination Survey 2008-2010

(2016) Do Seon Song et al.   PLoS One

Type 2 diabetes mellitus is associated with increased risks of sarcopenia and pre-sarcopenia in Chinese elderly

(2016) Taotao Wang et al.   Scientific Reports

Association between low muscle mass, functional limitations and hospitalisation in heart failure: NHANES 1999–2004

(2015) Julia R. DiBello et al.   AGE AND AGEING

Hormone replacement therapy and longevity

(2015) F. Comhaire   ANDROLOGIA

Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease

(2015) James A. Carson et al.   BONE

Relationship between sarcopenic obesity-related phenotypes and inflammatory markers in postmenopausal women

(2015) Maurílio Tiradentes Dutra et al.   CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING

Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity

(2015) Vanessa Pellegrinelli et al.   DIABETES

Obesity Appears to Be Associated With Altered Muscle Protein Synthetic and Breakdown Responses to Increased Nutrient Delivery in Older Men, but Not Reduced Muscle Mass or Contractile Function

(2015) Andrew J. Murton et al.   DIABETES

The Combination of Resveratrol and Quercetin Attenuates Metabolic Syndrome in Rats by Modifying the Serum Fatty Acid Composition and by Upregulating SIRT 1 and SIRT 2 Expression in White Adipose Tissue

(2015) Ana Elena Peredo-Escárcega et al.   Evidence-based Complementary and Alternative Medicine

Sarcopenia in post-menopausal women: Is there any role for vitamin D?

(2015) Panagiotis Anagnostis et al.   MATURITAS

Renin-Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle

(2015) Claudio Cabello-Verrugio et al.   MEDICINAL RESEARCH REVIEWS

Combination Antisense Treatment for Destructive Exon Skipping of Myostatin and Open Reading Frame Rescue of Dystrophin in Neonatal mdx Mice

(2015) Ngoc B Lu-Nguyen et al.   MOLECULAR THERAPY

Irisin – a myth rather than an exercise-inducible myokine

(2015) Elke Albrecht et al.   Scientific Reports

Gender-specific differences in the development of sarcopenia in the rodent model of the ageing high-fat rat

(2015) Robert Kob et al.   Journal of Cachexia Sarcopenia and Muscle

Sarcopenic obesity and myosteatosis are associated with higher mortality in patients with cirrhosis

(2015) Aldo J. Montano-Loza et al.   Journal of Cachexia Sarcopenia and Muscle

Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity

(2015) Mei Sian Chong et al.   Clinical Interventions in Aging

Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: From sarcopenic obesity to cachexia

(2014) Gianni Biolo et al.   CLINICAL NUTRITION

The Effects of Vitamin D on Skeletal Muscle Strength, Muscle Mass, and Muscle Power: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2014) Charlotte Beaudart et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle

(2014) Manon M Roustit et al.   JOURNAL OF ENDOCRINOLOGY

Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy

(2014) Ngoc Hoan Le et al.   MEDIATORS OF INFLAMMATION

Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adults

(2014) David Scott et al.   Obesity

Lkb1 Is Indispensable for Skeletal Muscle Development, Regeneration, and Satellite Cell Homeostasis

(2014) Tizhong Shan et al.   STEM CELLS

Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

(2013) M. Sandri et al.   BIOGERONTOLOGY

Medicinal Agents and Metabolic Syndrome

(2013) M.E. Rubio-Ruiz et al.   CURRENT MEDICINAL CHEMISTRY

Serum adipocyte fatty acid-binding protein levels are independently associated with sarcopenic obesity

(2013) Tae Nyun Kim et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity

(2013) Mats I. Nilsson et al.   FASEB JOURNAL

Estrogen replacement and skeletal muscle: mechanisms and population health

(2013) Peter M. Tiidus et al.   JOURNAL OF APPLIED PHYSIOLOGY

A Randomized Study on the Effect of Vitamin D3Supplementation on Skeletal Muscle Morphology and Vitamin D Receptor Concentration in Older Women

(2013) Lisa Ceglia et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

Sarcopenic obesity

(2013) Matthew F. Bouchonville et al.   Current Opinion in Endocrinology Diabetes and Obesity

Sarcopenic Obesity and Endocrinal Adaptation with Age

(2013) Kunihiro Sakuma et al.   International Journal of Endocrinology

The effect of vitamin D on insulin resistance in patients with type 2 diabetes

(2013) Afsaneh Talaei et al.   Diabetology & Metabolic Syndrome

Relationship between Low Free Testosterone Levels and Loss of Muscle Mass

(2013) Atsumu Yuki et al.   Scientific Reports

Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders

(2013) Rosamund C. Smith et al.   Current Opinion in Supportive and Palliative Care

Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women

(2012) Xuewen Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome: Lessons From the Fructose-Fed Rat Model

(2012) Y. Marcus et al.   DIABETES

Metabolic Effects of a Growth Hormone-Releasing Factor in Obese Subjects with Reduced Growth Hormone Secretion: A Randomized Controlled Trial

(2012) Hideo Makimura et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Role of Androgens and Estrogens on Healthy Aging and Longevity

(2012) A. M. Horstman et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Associação entre sarcopenia, obesidade sarcopênica e força muscular com variáveis relacionadas de qualidade de vida em idosas

(2012) Luiz S. Silva Neto et al.   Brazilian Journal of Physical Therapy

Adipose tissue-derived PAI-1: A molecular link for thrombo-inflammatory disease states?

(2012) Klaus T. Preissner   THROMBOSIS AND HAEMOSTASIS

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans

(2011) P.-M. Badin et al.   DIABETES

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

(2011) C. Zhang et al.   DIABETOLOGIA

Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet

(2011) P. M. Jamieson et al.   DIABETOLOGIA

Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway

(2011) C. Zhang et al.   DIABETOLOGIA

Re: Adverse Events Associated With Testosterone Administration

(2011) Abraham Morgentaler   EUROPEAN UROLOGY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

(2011) Y. S. Hori et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Altered Growth Hormone, Cortisol, and Leptin Secretion in Healthy Elderly Persons With Sarcopenia and Mixed Body Composition Phenotypes

(2011) D. L. Waters et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Dynapenia and Aging: An Update

(2011) Todd M. Manini et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation

(2011) DAVID L. ALLEN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes

(2011) Marika Leenders et al.   NUTRITION REVIEWS

The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial

(2011) James T. Dalton et al.   Journal of Cachexia Sarcopenia and Muscle

Impaired overload-induced hypertrophy is associated with diminished mTOR signaling in insulin-resistant skeletal muscle of the obese Zucker rat

(2010) Anjaiah Katta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypophosphatemia is responsible for skeletal muscle weakness of vitamin D deficiency

(2010) Laurie Schubert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sarcopenia

(2010) David R. Thomas   CLINICS IN GERIATRIC MEDICINE

Adipocyte-myocyte crosstalk in skeletal muscle insulin resistance; is there a role for thyroid hormone?

(2010) Bas Havekes et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model

(2010) Balindiwe Sishi et al.   EXPERIMENTAL PHYSIOLOGY

Genetic Studies Reveal the Role of the Endocrine and Metabolic Systems in Aging

(2010) Nir Barzilai et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Muscles and their myokines

(2010) B. K. Pedersen   JOURNAL OF EXPERIMENTAL BIOLOGY

Does Accumulation of Advanced Glycation End Products Contribute to the Aging Phenotype?

(2010) R. D. Semba et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Preventing sarcopaenia in older people

(2010) R. Visvanathan et al.   MATURITAS

PGC-1α-mediated adaptations in skeletal muscle

(2010) Jesper Olesen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Estrogen Regulates Estrogen Receptors and Antioxidant Gene Expression in Mouse Skeletal Muscle

(2010) Kristen A. Baltgalvis et al.   PLoS One

Secreted proteins from adipose tissue and skeletal muscle – adipokines, myokines and adipose/muscle cross-talk

(2010) Paul Trayhurn et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Advantages of dietary, exercise-related, and therapeutic interventions to prevent and treat sarcopenia in adult patients: an update

(2010) Debra Waters   Clinical Interventions in Aging

Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia

(2009) Emilie A Wilkes et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Obesity in older adults: relationship to functional limitation

(2009) Gordon L Jensen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes

(2009) R. A. DeFronzo et al.   DIABETES CARE

A Novel Synthetic Androgen Receptor Ligand, S42, Works as a Selective Androgen Receptor Modulator and Possesses Metabolic Effects with Little Impact on the Prostate

(2009) Liu Min et al.   ENDOCRINOLOGY

Measures of bioavailable serum testosterone and estradiol and their relationships with muscle mass, muscle strength and bone mineral density in postmenopausal women: a cross-sectional study

(2009) Tineke A C M van Geel et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Prevalence of sarcopenia and sarcopenic obesity in Korean adults: the Korean sarcopenic obesity study

(2009) T N Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

(2009) I Akpan et al.   INTERNATIONAL JOURNAL OF OBESITY

Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women

(2009) Christina M. Dieli-Conwright et al.   JOURNAL OF APPLIED PHYSIOLOGY

Changes in Basal and Insulin and Amino Acid Response of Whole Body and Skeletal Muscle Proteins in Obese Men

(2009) Christelle Guillet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Higher Inflammatory Marker Levels in Older Persons: Associations With 5-Year Change in Muscle Mass and Muscle Strength

(2009) L. A. Schaap et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Elevated Serum Advanced Glycation End Products and Poor Grip Strength in Older Community-Dwelling Women

(2009) M. Dalal et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity

(2009) Tingqing Guo et al.   PLoS One

The Influence of Estrogen on Skeletal Muscle

(2009) Deborah L. Enns et al.   SPORTS MEDICINE

Nutritional Supplements with Oral Amino Acid Mixtures Increases Whole-Body Lean Mass and Insulin Sensitivity in Elderly Subjects with Sarcopenia

(2008) Sebastiano B. Solerte et al.   AMERICAN JOURNAL OF CARDIOLOGY

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy

(2008) Kathryn R. Wagner et al.   ANNALS OF NEUROLOGY

Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

(2008) James G. Ryall et al.   BIOGERONTOLOGY

Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis

(2008) Micah J Drummond et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Sarcopenic obesity: definition, cause and consequences

(2008) Sari Stenholm et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Dietary protein recommendations and the prevention of sarcopenia

(2008) Douglas Paddon-Jones et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Lean Phenotype and Resistance to Diet-Induced Obesity in Vitamin D Receptor Knockout Mice Correlates with Induction of Uncoupling Protein-1 in White Adipose Tissue

(2008) Carmen J. Narvaez et al.   ENDOCRINOLOGY

The aging population – Is there a role for endocrine interventions?

(2008) Ralf Nass et al.   GROWTH HORMONE & IGF RESEARCH

The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance

(2008) A. M. Traish et al.   JOURNAL OF ANDROLOGY

Serum Total and Bioavailable Testosterone Levels, Central Obesity, and Muscle Strength Changes with Aging in Healthy Chinese Men

(2008) Leung-Wing Chu et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Single muscle fiber contractile properties in adults with muscular dystrophy treated with MYO-029

(2008) Lisa S. Krivickas et al.   MUSCLE & NERVE

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY