Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer’s patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability

Amyloid-Beta1-42 -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells

(2020) Beatriz Calvo-Flores Guzmán et al.   MOLECULES

Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain

(2020) Lindsay A. Welikovitch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

(2020) Fang Zhang et al.   Science Translational Medicine

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

(2020) Martí Colom-Cadena et al.   Alzheimers Research & Therapy

Amyloid Beta42 oligomers up‐regulate the excitatory synapses by potentiating presynaptic release while impairing postsynaptic NMDA receptors

(2020) Andrea Marcantoni et al.   JOURNAL OF PHYSIOLOGY-LONDON

Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

(2019) Yang He et al.   Nature Communications

Curcumin Alleviates β Amyloid-Induced Neurotoxicity in HT22 Cells via Upregulating SOD2

(2019) Shuping Du et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

(2019) Matthew J Betts et al.   BRAIN

Localization of amyloid beta peptides to locus coeruleus and medial prefrontal cortex in corticotropin releasing factor overexpressing male and female mice

(2019) Jennifer A. Ross et al.   Brain Structure & Function

Targeting the Synapse in Alzheimer’s Disease

(2019) Johanna Jackson et al.   Frontiers in Neuroscience

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

(2019) Woo Shik Shin et al.   Alzheimers Research & Therapy

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation

(2019) Woo Shik Shin et al.   Frontiers in Molecular Neuroscience

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

(2019) Yu Ding et al.   Frontiers in Neurology

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

(2019) Eleanor K. Pickett et al.   Cell Reports

Oxidative Stress and Decreased Mitochondrial Superoxide Dismutase 2 and Peroxiredoxins 1 and 4 Based Mechanism of Concurrent Activation of AMPK and mTOR in Alzheimer’s Disease

(2018) Shohreh Majd et al.   Current Alzheimer Research

GABA A Receptor Subtypes Regulate Stress-induced Colon Inflammation in Mice

(2018) Mohsen Seifi et al.   GASTROENTEROLOGY

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Image co-localization – co-occurrence versus correlation

(2018) Jesse S. Aaron et al.   JOURNAL OF CELL SCIENCE

GABAA receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus

(2018) Andrea Kwakowsky et al.   JOURNAL OF NEUROCHEMISTRY

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

(2018) David Weinshenker   TRENDS IN NEUROSCIENCES

Spatiotemporal Distribution of GABAA Receptor Subunits Within Layer II of Mouse Medial Entorhinal Cortex: Implications for Grid Cell Excitability

(2018) Nina Berggaard et al.   Frontiers in Neuroanatomy

Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies

(2018) Andrew C. Peterson et al.   Frontiers in Aging Neuroscience

GABA Attenuates Amyloid Toxicity by Downregulating its Endocytosis and Improves Cognitive Impairment

(2018) Xiaqin Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors

(2018) Elena Neumann et al.   NEUROPHARMACOLOGY

Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross-seeding behavior

(2018) Gaurav Ghag et al.   PROTEIN SCIENCE

Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex

(2018) Lindsay A. Welikovitch et al.   ACTA NEUROPATHOLOGICA

Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors

(2018) Elba Campos-Lira et al.   Frontiers in Neuroscience

In vivo induction of membrane damage by β-amyloid peptide oligomers

(2018) Carl Julien et al.   Acta Neuropathologica Communications

Pupillary Responses as a Biomarker of Early Risk for Alzheimer’s Disease

(2017) Eric L. Granholm et al.   JOURNAL OF ALZHEIMERS DISEASE

Oligomeric amyloid-β peptide disrupts olfactory information output by impairment of local inhibitory circuits in rat olfactory bulb

(2017) Bin Hu et al.   NEUROBIOLOGY OF AGING

Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability

(2016) Martijn C. de Wilde et al.   Alzheimers & Dementia

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Locus Coeruleus in time with the making of memories

(2015) Susan J Sara   CURRENT OPINION IN NEUROBIOLOGY

Olfactory dysfunction: its early temporal relationship and neural correlates in the pathogenesis of Alzheimer’s disease

(2015) Mak Adam Daulatzai   JOURNAL OF NEURAL TRANSMISSION

Amyloid-  Impairs Synaptic Inhibition via GABAA Receptor Endocytosis

(2015) D. Ulrich   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety

(2015) Jordan G. McCall et al.   NEURON

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus

(2014) Nicole L. Corteen et al.   Brain Structure & Function

Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase

(2014) Javier Sanchez-Padilla et al.   NATURE NEUROSCIENCE

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

(2014) Pasquale Picone et al.   Oxidative Medicine and Cellular Longevity

Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions

(2014) Eydith Comenencia-Ortiz et al.   PSYCHOPHARMACOLOGY

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

(2013) Johanna L. Crimins et al.   AGEING RESEARCH REVIEWS

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

(2013) Jian Luo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn

(2013) V.-S. Eckle et al.   NEUROSCIENCE

Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain

(2013) H. Hörtnagl et al.   NEUROSCIENCE

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease

(2012) Katsuya Harada et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tonic Inhibition in Principal Cells of the Amygdala: A Central Role for  3 Subunit-Containing GABAA Receptors

(2012) A. Marowsky et al.   JOURNAL OF NEUROSCIENCE

Localization of GABA-A receptor alpha subunits on neurochemically distinct cell types in the rat locus coeruleus

(2011) Nicole L. Corteen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity

(2011) Fuxiang Bao et al.   NEUROBIOLOGY OF AGING

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

The Brainstem Noradrenergic Systems in Stress, Anxiety and Depression

(2010) K. Itoi et al.   JOURNAL OF NEUROENDOCRINOLOGY

Tuning arousal with optogenetic modulation of locus coeruleus neurons

(2010) Matthew E Carter et al.   NATURE NEUROSCIENCE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neonatal rearing conditions distinctly shape locus coeruleus neuronal activity, dendritic arborization, and sensitivity to corticotrophin-releasing factor

(2009) Jerome D. Swinny et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution

(2009) Zhenglin Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential localization of γ-aminobutyric acid type a and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: An immunohistochemical study

(2009) H.J. Waldvogel et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergent regulation of locus coeruleus activity as an adaptive response to stress

(2008) Rita J. Valentino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition

(2008) Tija C. Jacob et al.   NATURE REVIEWS NEUROSCIENCE

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA