Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism

Glycolysis – a key player in the inflammatory response

(2020) Gonzalo Soto‐Heredero et al.   FEBS Journal

Inhibition of glycolysis ameliorate arthritis in adjuvant arthritis rats by inhibiting synoviocyte activation through AMPK/NF-кB pathway

(2020) Ying Wang et al.   INFLAMMATION RESEARCH

Glycolysis and mitochondrial function regulate the radical oxygen species production induced by platelet-activating factor in bovine polymorphonuclear leukocytes

(2020) John Quiroga et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Andrographis paniculata and Its Bioactive Diterpenoids Protect Dermal Fibroblasts against Inflammation and Oxidative Stress

(2020) Eugenie Mussard et al.   Antioxidants

From Overnutrition to Liver Injury: AMP-Activated Protein Kinase in Nonalcoholic Fatty Liver Diseases

(2020) Peng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells

(2020) Xiaofei Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Andrographolide modulates HNF4α activity imparting on hepatic metabolism

(2020) Minyi Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The interplay between immunosenescence and age-related diseases

(2020) Florencia Barbé-Tuana et al.   Seminars in Immunopathology

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

(2020) Ammad Ahmad Farooqi et al.   Cancers

Visualization of GLUT1 Trafficking in Live Cancer Cells by the Use of a Dual-Fluorescence Reporter

(2020) Zhen-Yan Li et al.   ACS Omega

Oleic and Linoleic Acids Induce the Release of Neutrophil Extracellular Traps via Pannexin 1-Dependent ATP Release and P2X1 Receptor Activation

(2020) Pablo Alarcón et al.   Frontiers in Veterinary Science

The Role of HIF in Immunity and Inflammation

(2020) Anne F. McGettrick et al.   Cell Metabolism

NET formation – mechanisms and how they relate to other cell death pathways

(2020) Thibault Rosazza et al.   FEBS Journal

TLR4/AP-1-Targeted Anti-Inflammatory Intervention Attenuates Insulin Sensitivity and Liver Steatosis

(2020) Xiang Hu et al.   MEDIATORS OF INFLAMMATION

Specialized pro-resolving mediators: It’s anti-oxidant stress role in multiple disease models

(2020) Fuquan Wang et al.   MOLECULAR IMMUNOLOGY

Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases

(2020) Claudia Orrù et al.   Cancers

Control of Cell Identity by the Nuclear Receptor HNF4 in Organ Pathophysiology

(2020) Vanessa Dubois et al.   Cells

Mitochondria-derived ATP participates in the formation of neutrophil extracellular traps induced by platelet-activating factor through purinergic signaling in cows

(2020) John Quiroga et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Andrographolide restores glucose uptake in rat hippocampal neurons

(2020) Camila Gherardelli et al.   JOURNAL OF NEUROCHEMISTRY

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

A double‐blind, randomized, placebo‐controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis

(2019) Juan L. Hancke et al.   PHYTOTHERAPY RESEARCH

Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities

(2019) Wang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotection of Andrographolide Against Microglia-Mediated Inflammatory Injury and Oxidative Damage in PC12 Neurons

(2019) Yuanzhen Xu et al.   NEUROCHEMICAL RESEARCH

Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology

(2019) Mithunan Ravindran et al.   Biomolecules

The hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis

(2019) Hongming Lv et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis–NETosis Balance of Neutrophils

(2019) Xiaohong Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs

(2019) Ming-Xia Duan et al.   MEDIATORS OF INFLAMMATION

Neutrophil Extracellular Traps and Liver Disease

(2019) Moira B. Hilscher et al.   SEMINARS IN LIVER DISEASE

Andrographolide, A Natural Antioxidant: An Update

(2019) Eugenie Mussard et al.   Antioxidants

Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK

(2019) Nami Kim et al.   BIOCHEMICAL PHARMACOLOGY

JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression

(2019) Katie L. Owen et al.   Cancers

Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis

(2018) Xiaobo Yang et al.   DNA AND CELL BIOLOGY

Andrographolide Antagonizes TNF-α-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-κB and Src/MAPKs/AP-1 Axis in Human Colorectal Cancer HCT116 Cells

(2018) Miaomiao Yuan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Andrographolide affects Th1/Th2/Th17 responses of peripheral blood mononuclear cells from ulcerative colitis patients

(2018) Qin Zhu et al.   Molecular Medicine Reports

JAK/STAT – Emerging Players in Metabolism

(2018) David W. Dodington et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis

(2018) Trudy McGarry et al.   Arthritis & Rheumatology

Andrographolide enhances redox status of liver cells by regulating microRNA expression

(2018) Swati Khole et al.   FREE RADICAL BIOLOGY AND MEDICINE

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

(2018) Yulin Peng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The ERK and JNK pathways in the regulation of metabolic reprogramming

(2018) Salvatore Papa et al.   ONCOGENE

Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation

(2018) Jan Rossaint et al.   Frontiers in Immunology

Andrographolide Inhibits Inflammatory Cytokines Secretion in LPS-Stimulated RAW264.7 Cells through Suppression of NF-κB/MAPK Signaling Pathway

(2017) Yu Li et al.   Evidence-based Complementary and Alternative Medicine

Andrographolide Benefits Rheumatoid Arthritis via Inhibiting MAPK Pathways

(2017) Zun-zhong Li et al.   INFLAMMATION

Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway

(2017) Yi Ding et al.   MICROBES AND INFECTION

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway

(2017) Chen-wei Pan et al.   Oncotarget

Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome

(2017) Muhammad T. Islam   Frontiers in Pharmacology

Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis

(2017) Swati Gupta et al.   INFLAMMOPHARMACOLOGY

Andrographolide protects liver cells from H 2 O 2 induced cell death by upregulation of Nrf-2/HO-1 mediated via adenosine A 2a receptor signalling

(2016) Smriti P.K. Mittal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Central insulin-mediated regulation of hepatic glucose production [Review]

(2016) Hiroshi Inoue   ENDOCRINE JOURNAL

Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells

(2016) Hung-Chih Lin et al.   ENVIRONMENTAL TOXICOLOGY

Adenosine monophosphate-activated protein kinase activation and suppression of inflammatory response by cell stretching in rabbit synovial fibroblasts

(2016) Wanlop Kunanusornchai et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes

(2016) Ricard Garcia-Carbonell et al.   Arthritis & Rheumatology

Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis

(2016) Susan Hua et al.   Frontiers in Pharmacology

Crosstalk of HNF4 α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids

(2016) Hong Lu   Acta Pharmaceutica Sinica B

AMP-activated protein kinase: Structure, function, and role in pathological processes

(2015) D. S. Novikova et al.   BIOCHEMISTRY-MOSCOW

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

NF-κB and HIF crosstalk in immune responses

(2015) Laura D'Ignazio et al.   FEBS Journal

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

(2015) Yi Bao et al.   JOURNAL OF CELL BIOLOGY

Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes via inhibition of HIF-1α signaling

(2015) Guo-feng Li et al.   LIFE SCIENCES

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

(2015) Elena Doménech et al.   NATURE CELL BIOLOGY

Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes

(2015) Hongming Miao et al.   Scientific Reports

AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages

(2014) Yun Wang et al.   ANNALS OF THE RHEUMATIC DISEASES

Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/491 through Akt in hepatocytes, myotubes and incubated rat skeletal muscle

(2014) Rudy J. Valentine et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells

(2014) Chia-Yang Lu et al.   BIOCHEMICAL PHARMACOLOGY

Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin

(2014) Sarandeep S. S. Boyanapalli et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Obesity indices and inflammatory markers in obese non-diabetic normo- and hypertensive patients: a comparative pilot study

(2014) Mariusz Stępień et al.   Lipids in Health and Disease

A Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent That Suppresses Tumor Metastasis

(2014) Jigang Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Andrographis paniculata(Burm. f.) Wall. ex Nees: A Review of Ethnobotany, Phytochemistry, and Pharmacology

(2014) Md. Sanower Hossain et al.   TheScientificWorldJOURNAL

Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells

(2013) Jin-Ching Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammation Amplifier, a New Paradigm in Cancer Biology

(2013) T. Atsumi et al.   CANCER RESEARCH

AP-1/IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated fromAndrographis paniculata

(2013) Ting Shen et al.   Evidence-based Complementary and Alternative Medicine

Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB

(2013) Tao Zhu et al.   PLoS One

Changes in the contents of four active diterpenoids at different growth stages in Andrographis paniculata (Burm.f.) Nees (Chuanxinlian)

(2013) Nanthanit Pholphana et al.   Chinese Medicine

Andrographis paniculata Extract (HMPL-004) for Active Ulcerative Colitis

(2012) William J Sandborn et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity

(2012) SP Guan et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses

(2012) Se Eun Byeon et al.   MEDIATORS OF INFLAMMATION

Hypolipidemic Effects of Andrographolide and Neoandrographolide in Mice and Rats

(2012) Tao Yang et al.   PHYTOTHERAPY RESEARCH

A NET Outcome

(2012) Thea Lu et al.   Frontiers in Immunology

Anti-inflammatory effect of novel andrographolide derivatives through inhibition of NO and PGE2 production

(2011) Gui-Fu Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Andrographolide Inhibits ICAM-1 Expression and NF-κB Activation in TNF-α-Treated EA.hy926 Cells

(2011) Che-Yi Chao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of TNF-α-Induced Inflammation by Andrographolide via Down-Regulation of the PI3K/Akt Signaling Pathway

(2011) Haw-Wen Chen et al.   JOURNAL OF NATURAL PRODUCTS

Andrographolide attenuates tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes

(2010) Lina Jin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oxidative stress in the brain of nicotine-induced toxicity: protective role of Andrographis paniculata Nees and vitamin E

(2009) Subhasis Das et al.   Applied Physiology Nutrition and Metabolism

Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin

(2009) Jing Zhou et al.   BIOCHEMICAL PHARMACOLOGY

Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial

(2009) R. A. Burgos et al.   CLINICAL RHEUMATOLOGY

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Reactive Oxygen Species Facilitate Adipocyte Differentiation by Accelerating Mitotic Clonal Expansion

(2009) Haemi Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant, antioedema and analgesic activities ofAndrographis paniculataextracts and their active constituent andrographolide

(2009) F. L. Lin et al.   PHYTOTHERAPY RESEARCH

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Simvastatin activates Keap1/Nrf2 signaling in rat liver

(2008) Ioannis G. Habeos et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Role of hypoxia-inducible factor-1  in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes

(2008) J. K. Ahn et al.   RHEUMATOLOGY