Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells

Andrographolide inhibits hypoxia-inducible factor-1 through phosphatidylinositol 3-kinase/AKT pathway and suppresses breast cancer growth

(2015) Jie Li et al.   OncoTargets and Therapy

Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells

(2014) Chia-Yang Lu et al.   BIOCHEMICAL PHARMACOLOGY

Modulation of thioacetamide-induced hepatic inflammations, angiogenesis and fibrosis by andrographolide in mice

(2014) Tzung-Yan Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats

(2014) Haw-Wen Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A survey of medicinal plants used by the Deb barma clan of the Tripura tribe of Moulvibazar district, Bangladesh

(2014) Mohammad Kabir et al.   Journal of Ethnobiology and Ethnomedicine

Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells

(2013) Che-Yi Chao et al.   CARCINOGENESIS

Preventive effects of andrographolide on the development of diabetes in autoimmune diabetic NOD mice by inducing immune tolerance

(2013) Chengliang Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells

(2013) M-H Wu et al.   ONCOGENE

Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells

(2013) Atsushi Sato et al.   Stem Cell Research

Silibinin inhibits VEGF secretion and age-related macular degeneration in a hypoxia-dependent manner through the PI-3 kinase/Akt/mTOR pathway

(2012) CH Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Redox Signaling in Cardiac Physiology and Pathology

(2012) Joseph R. Burgoyne et al.   CIRCULATION RESEARCH

Effects of Induction/Inhibition of Endogenous Heme Oxygenase-1 on Lipid Metabolism, Endothelial Function, and Atherosclerosis in Rabbits on a High Fat Diet

(2012) Danan Liu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Epigenetic mechanisms for silencing glutathione S-transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer

(2011) Sheau-Chung Tang et al.   CANCER

Induction of Heme Oxygenase 1 Attenuates Placental Ischemia–Induced Hypertension

(2011) Eric M. George et al.   HYPERTENSION

Andrographolide Inhibits ICAM-1 Expression and NF-κB Activation in TNF-α-Treated EA.hy926 Cells

(2011) Che-Yi Chao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway

(2011) Ko-Chen Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibition of TNF-α-Induced Inflammation by Andrographolide via Down-Regulation of the PI3K/Akt Signaling Pathway

(2011) Haw-Wen Chen et al.   JOURNAL OF NATURAL PRODUCTS

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin

(2011) Eric M. George et al.   International Journal of Hypertension

Induction of Heme Oxygenase 1 and Inhibition of Tumor Necrosis Factor α-Induced Intercellular Adhesion Molecule Expression by Andrographolide in EA.hy926 Cells

(2010) Ai-Lin Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells

(2010) Hui-Hsuan Lin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-κB Pathway

(2009) Zhang Bao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation

(2009) Dyah W. Anggrahini et al.   CARDIOVASCULAR RESEARCH

Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells

(2009) Preamrudee Poomthavorn et al.   ENDOCRINE-RELATED CANCER

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Induction of HIF-1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+signaling, prolyl hydroxylases, and mTOR

(2008) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Andrographolide Up-Regulates Cellular-Reduced Glutathione Level and Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury

(2008) A. Y. H. Woo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS