Emerging Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer Immunotherapy

Endoplasmic reticulum-associated degradation and beyond: The multitasking roles for HRD1 in immune regulation and autoimmunity

(2020) Yuanming Xu et al.   JOURNAL OF AUTOIMMUNITY

The E3 ubiquitin ligase HRD1 promotes lung tumorigenesis by promoting sirtuin 2 ubiquitination and degradation

(2020) Liu Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

The emerging role of SPOP protein in tumorigenesis and cancer therapy

(2020) Yizuo Song et al.   Molecular Cancer

The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells

(2020) Yu Wang et al.   Cell Communication and Signaling

N-glycosylation and ubiquitinylation of PD-L1 do not restrict interaction with BMS-202: A molecular modeling study

(2020) Christian Bailly et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Rho‐associated protein kinase‐dependent moesin phosphorylation is required for PD‐L1 stabilization in breast cancer

(2020) Fanbiao Meng et al.   Molecular Oncology

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

(2020) Yang Gao et al.   NATURE CELL BIOLOGY

2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1

(2020) Zhanfei Chen et al.   Journal for ImmunoTherapy of Cancer

WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP

(2019) Seok Kim et al.   Cancers

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1

(2019) Hui Li et al.   GASTROENTEROLOGY

The role of PD-1/PD-L1 axis and macrophage in the progression and treatment of cancer

(2019) Jiajing Cai et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Ubiquitin Signaling and Degradation of Aggregate-Prone Proteins

(2019) Margarita Galves et al.   TRENDS IN BIOCHEMICAL SCIENCES

c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis

(2019) Chimera L. Lyle et al.   Cells

Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation

(2019) Liang Deng et al.   ONCOGENE

Increased CMTM6 can predict the clinical response to PD-1 inhibitors in non-small cell lung cancer patients

(2019) Young Wha Koh et al.   OncoImmunology

STUB1 suppresseses tumorigenesis and chemoresistance through antagonizing YAP1 signaling

(2019) Dong‐E Tang et al.   CANCER SCIENCE

USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation

(2019) Pingping Hou et al.   GENES & DEVELOPMENT

USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity

(2019) Xing Huang et al.   Cancer Immunology Research

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Targeting CMTM6 suppresses stem cell-like properties and enhances antitumor immunity in head and neck squamous cell carcinoma

(2019) Lei Chen et al.   Cancer Immunology Research

Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway

(2019) Chao Liu et al.   CELL DEATH AND DIFFERENTIATION

Blocking PD-L1 for anti-liver cancer immunity: USP22 represents a critical cotarget

(2019) Xing Huang et al.   Cellular & Molecular Immunology

Quantitative Assessment of CMTM6 in the Tumor Microenvironment and Association with Response to PD-1 Pathway Blockade in Advanced-Stage Non–Small Cell Lung Cancer

(2019) Jon Zugazagoitia et al.   Journal of Thoracic Oncology

Harnessing tumor-associated macrophages as aids for cancer immunotherapy

(2019) Xiaolei Li et al.   Molecular Cancer

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

(2019) Keelan Z. Guiley et al.   SCIENCE

c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth

(2019) Chimera Lyle et al.   Scientific Reports

Tumor Cell–Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer

(2019) Jinyang Li et al.   Cancer Immunology Research

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1 dependent mechanism

(2018) Johanna Melo-Cardenas et al.   BLOOD

USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma

(2018) Huijuan Zhang et al.   CANCER LETTERS

Loss of the Nuclear Pool of Ubiquitin Ligase CHIP/STUB1 in Breast Cancer Unleashes the MZF1-Cathepsin Pro-oncogenic Program

(2018) Haitao Luan et al.   CANCER RESEARCH

HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression

(2018) Liu Liu et al.   CELLULAR SIGNALLING

E3 ubiquitin ligases Cbl-b and c-Cbl downregulate PD-L1 in EGFR wild-type non-small cell lung cancer

(2018) Shuo Wang et al.   FEBS LETTERS

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer

(2018) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

The E3 ligase C-CBL inhibits cancer cell migration by neddylating the proto-oncogene c-Src

(2018) Gun-Woo Lee et al.   ONCOGENE

Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation

(2018) Wolfgang Dubiel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Deubiquitination and stabilization of programmed cell death ligand 1 by ubiquitin-specific peptidase 9, X-linked in oral squamous cell carcinoma

(2018) Wu Jingjing et al.   Cancer Medicine

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas

(2018) Xiudong Guan et al.   EBioMedicine

MiR-940 promotes the proliferation and migration of gastric cancer cells through up-regulation of programmed death ligand-1 expression

(2018) Yibo Fan et al.   EXPERIMENTAL CELL RESEARCH

DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer

(2018) Jing Li et al.   EXPERIMENTAL CELL RESEARCH

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

(2018) Xiangbo Meng et al.   NATURE

Uncovering the Structural Basis of a New Twist in Protein Ubiquitination

(2018) Kedar Puvar et al.   TRENDS IN BIOCHEMICAL SCIENCES

Squamous cell carcinoma–related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21protein complex during abscission

(2017) Guochang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration

(2017) Shuji Wakatsuki et al.   JOURNAL OF CELL BIOLOGY

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

(2017) Riccardo Mezzadra et al.   NATURE

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

(2017) Jinfang Zhang et al.   NATURE

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

Deubiquitylating enzymes and drug discovery: emerging opportunities

(2017) Jeanine A. Harrigan et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting DCUN1D1

(2017) Jing Xiao et al.   ONCOLOGY RESEARCH

Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition

(2017) Sebastian Peer et al.   Oncotarget

The role of ubiquitination and deubiquitination in the regulation of cell junctions

(2017) Junting Cai et al.   Protein & Cell

Cbl-b Deficiency Mediates Resistance to Programed Death-Ligand 1/Programed Death-1 Regulation

(2017) Mai Fujiwara et al.   Frontiers in Immunology

Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer

(2017) Lucile Jeusset et al.   Cancers

Deubiquitination and Stabilization of PD-L1 by CSN5

(2016) Seung-Oe Lim et al.   CANCER CELL

Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD

(2016) Ryan D. Baldridge et al.   CELL

Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome

(2016) Simone Cavadini et al.   NATURE

Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas

(2016) Sinyi Kong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PD-L1 expression in human cancers and its association with clinical outcomes

(2016) Jinming Yu et al.   OncoTargets and Therapy

USP21 prevents the generation of T-helper-1-like Treg cells

(2016) Yangyang Li et al.   Nature Communications

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

(2016) Chia-Wei Li et al.   Nature Communications

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

(2016) Yuanming Xu et al.   Nature Communications

MicroRNA-218 inhibits EMT, migration and invasion by targeting SFMBT1 and DCUN1D1 in cervical cancer

(2016) Zhaojing Jiang et al.   Oncotarget

WP1130 increases doxorubicin sensitivity in hepatocellular carcinoma cells through usp9x-dependent p53 degradation

(2015) Hao Liu et al.   CANCER LETTERS

La FAM fatale: USP9X in development and disease

(2015) Mariyam Murtaza et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The unravelling of the ubiquitin system

(2015) Aaron Ciechanover   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway

(2015) Kim C. Ohaegbulam et al.   TRENDS IN MOLECULAR MEDICINE

The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis

(2015) Lingyun Zhang et al.   Oncotarget

SCCRO Promotes Glioma Formation and Malignant Progression in Mice

(2015) Stephen R. Broderick et al.   NEOPLASIA

SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells

(2014) Ling Li et al.   Cell Stem Cell

USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma

(2014) ZHEN NING et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X

(2014) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells

(2014) Heming Li et al.   Molecular Cancer

Ubiquitin-specific protease 22-induced autophagy is correlated with poor prognosis of pancreatic cancer

(2014) JIN-XIAO LIANG et al.   ONCOLOGY REPORTS

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer

(2014) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHIP/Stub1 functions as a tumor suppressor and represses NF- B-mediated signaling in colorectal cancer

(2013) Y. Wang et al.   CARCINOGENESIS

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

(2013) Pascal Genschik et al.   EMBO JOURNAL

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

(2013) Zuojia Chen et al.   IMMUNITY

Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

(2013) Jorg van Loosdregt et al.   IMMUNITY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex

(2013) Yoon Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1

(2013) Aude Echalier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells

(2013) Thomas Gruber et al.   Journal of Molecular Cell Biology

Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

(2013) E. A. Akbay et al.   Cancer Discovery

Regulation of NF-κB by ubiquitination and degradation of the IκBs

(2012) Naama Kanarek et al.   IMMUNOLOGICAL REVIEWS

Identification of Ubiquitin-specific Protease 9X (USP9X) as a Deubiquitinase Acting on Ubiquitin-Peroxin 5 (PEX5) Thioester Conjugate

(2012) Cláudia P. Grou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCFβ-TRCPsuppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2

(2012) Shavali Shaik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

(2012) Zhenghong Lin et al.   MOLECULAR CELL

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

(2012) Pedro A. Pérez-Mancera et al.   NATURE

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages

(2011) Z. Deng et al.   BLOOD

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+T cells

(2011) Katarzyna Karwacz et al.   EMBO Molecular Medicine

USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1

(2011) Boyko S Atanassov et al.   EMBO REPORTS

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation

(2011) Shuji Wakatsuki et al.   NATURE CELL BIOLOGY

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Human ITCH E3 Ubiquitin Ligase Deficiency Causes Syndromic Multisystem Autoimmune Disease

(2010) Naomi J. Lohr et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Cbl-b-/- T Cells Demonstrate In Vivo Resistance to Regulatory T Cells but a Context-Dependent Resistance to TGF- 

(2010) C. O. Adams et al.   JOURNAL OF IMMUNOLOGY

Region-Specific Protein Abundance Changes in the Brain of MPTP-Induced Parkinson’s Disease Mouse Model

(2010) Xu Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Cbl-b in T-cell activation

(2010) Magdalena Paolino et al.   Seminars in Immunopathology

JAB1/CSN5: a new player in cell cycle control and cancer

(2010) Terry J Shackleford et al.   Cell Division

COP9-Associated CSN5 Regulates Exosomal Protein Deubiquitination and Sorting

(2009) Yuelong Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals

(2009) Xiujuan Qu et al.   FEBS LETTERS

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression

(2008) A. S. Adler et al.   CANCER RESEARCH

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

(2008) Brian T. Fife et al.   IMMUNOLOGICAL REVIEWS

The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression

(2008) Xiao-Yong Zhang et al.   MOLECULAR CELL