The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

(2013) Akihito Ohta et al.   BIOCHEMICAL JOURNAL

Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

(2013) Nathan W. Pierce et al.   CELL

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

(2013) Peter Canning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation-dependent localization of PLK1 in mitosis

(2013) Jochen Beck et al.   NATURE CELL BIOLOGY

A Quantitative Proteomic Analysis Uncovers the Relevance of CUL3 in Bladder Cancer Aggressiveness

(2013) Laura Grau et al.   PLoS One

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

(2013) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CSN- and CAND1-dependent remodelling of the budding yeast SCF complex

(2013) Aleksandra Zemla et al.   Nature Communications

CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire

(2013) Shuangding Wu et al.   Nature Communications

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

(2013) Mai Wakabayashi et al.   Cell Reports

A Homozygous Mutation in KCTD7 Links Neuronal Ceroid Lipofuscinosis to the Ubiquitin-Proteasome System

(2012) John F. Staropoli et al.   AMERICAN JOURNAL OF HUMAN GENETICS

KBTBD13 interacts with Cullin 3 to form a functional ubiquitin ligase

(2012) Nyamkhishig Sambuughin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis

(2012) H. Ohnuki et al.   BLOOD

Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase

(2012) Christopher J. Pelham et al.   Cell Metabolism

Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control

(2012) A. Mocciaro et al.   JOURNAL OF CELL SCIENCE

Translational Homeostasis via the mRNA Cap-Binding Protein, eIF4E

(2012) Akiko Yanagiya et al.   MOLECULAR CELL

TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer

(2012) Francois Gonzalvez et al.   MOLECULAR CELL

Ubiquitin-dependent regulation of COPII coat size and function

(2012) Lingyan Jin et al.   NATURE

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

(2012) Hélène Louis-Dit-Picard et al.   NATURE GENETICS

Germline-Specific MATH-BTB Substrate Adaptor MAB1 Regulates Spindle Length and Nuclei Identity in Maize

(2012) M. Juranic et al.   PLANT CELL

The Light-Response BTB1 and BTB2 Proteins Assemble Nuclear Ubiquitin Ligases That Modify Phytochrome B and D Signaling in Arabidopsis

(2012) M. J. Christians et al.   PLANT PHYSIOLOGY

Cullin-3 regulates late endosome maturation

(2012) J. Huotari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptor Protein Self-Assembly Drives the Control of a Cullin-RING Ubiquitin Ligase

(2012) Wesley J. Errington et al.   STRUCTURE

The Cullin-RING Ubiquitin-Protein Ligases

(2011) Zhihua Hua et al.   Annual Review of Plant Biology

Molecular organization of the cullin E3 ligase adaptor KCTD11

(2011) Stefania Correale et al.   BIOCHIMIE

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

(2011) Wei-Chien Yuan et al.   CANCER CELL

The Cullin7 E3 ubiquitin ligase: A novel player in growth control

(2011) Antonio Sarikas et al.   CELL CYCLE

Polar-localized NPH3-like proteins regulate polarity and endocytosis of PIN-FORMED auxin efflux carriers

(2011) M. Furutani et al.   DEVELOPMENT

MATH/BTB CRL3 Receptors Target the Homeodomain-Leucine Zipper ATHB6 to Modulate Abscisic Acid Signaling

(2011) E. Lechner et al.   DEVELOPMENTAL CELL

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Ubiquitin Ligase Activity of Cul3-KLHL7 Protein Is Attenuated by Autosomal Dominant Retinitis Pigmentosa Causative Mutation

(2011) Yu Kigoshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer

(2011) Kelsie L. Thu et al.   Journal of Thoracic Oncology

Progressive Myoclonic Epilepsy-Associated Gene KCTD7 is a Regulator of Potassium Conductance in Neurons

(2011) Régis Azizieh et al.   MOLECULAR NEUROBIOLOGY

Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

(2011) C Li et al.   ONCOGENE

Modulation of Phototropic Responsiveness in Arabidopsis through Ubiquitination of Phototropin 1 by the CUL3-Ring E3 Ubiquitin Ligase CRL3NPH3

(2011) D. Roberts et al.   PLANT CELL

Arabidopsisα Aurora Kinases Function in Formative Cell Division Plane Orientation

(2011) Daniël Van Damme et al.   PLANT CELL

Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response

(2011) C. Ferry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

(2011) D. C. Scott et al.   SCIENCE

Protein Phosphatase 2A Controls Ethylene Biosynthesis by Differentially Regulating the Turnover of ACC Synthase Isoforms

(2011) Kyle R. Skottke et al.   PLoS Genetics

Dominant Mutations in KBTBD13, a Member of the BTB/Kelch Family, Cause Nemaline Myopathy with Cores

(2010) Nyamkhishig Sambuughin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy

(2010) Sebahattin Cirak et al.   BRAIN

Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics

(2010) Eric J. Bennett et al.   CELL

Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation

(2010) Jeong-Eun Kim et al.   CELLULAR SIGNALLING

Plant stomata: a checkpoint of host immunity and pathogen virulence

(2010) Weiqing Zeng et al.   CURRENT OPINION IN BIOTECHNOLOGY

Selective proteolysis sets the tempo of the cell cycle

(2010) Katia Marrocco et al.   CURRENT OPINION IN PLANT BIOLOGY

The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses

(2010) Yu-Ru Lee et al.   EMBO JOURNAL

A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation

(2010) D. F. Sobieszczuk et al.   GENES & DEVELOPMENT

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

(2010) Kathryn C. Claiborn et al.   JOURNAL OF CLINICAL INVESTIGATION

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

(2010) Uta Kossatz et al.   JOURNAL OF CLINICAL INVESTIGATION

A Dual E3 Mechanism for Rub1 Ligation to Cdc53

(2010) Daniel C. Scott et al.   MOLECULAR CELL

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Proteasome-Mediated Turnover of the Transcription Coactivator NPR1 Plays Dual Roles in Regulating Plant Immunity

(2009) Steven H. Spoel et al.   CELL

Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization

(2009) J. Merlet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

The Cul3/Klhdc5 E3 Ligase Regulates p60/Katanin and Is Required for Normal Mitosis in Mammalian Cells

(2009) Cristina M. Cummings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Rapsyn Stability by the CUL-3-containing E3 Ligase Complex

(2009) Seunghee Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis

(2009) Sarah Maerki et al.   JOURNAL OF CELL BIOLOGY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement

(2009) Yuezhou Chen et al.   MOLECULAR CELL

Recent advances and emerging trends in plant hormone signalling

(2009) Aaron Santner et al.   NATURE

Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays

(2009) Yifat Merbl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

(2009) Qing Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer

(2009) J. Liu et al.   SCIENCE

Arabidopsis CULLIN3 Genes Regulate Primary Root Growth and Patterning by Ethylene-Dependent and -Independent Mechanisms

(2009) Alexis Thomann et al.   PLoS Genetics

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Coordinated Activation of the Nuclear Ubiquitin Ligase Cul3-SPOP by the Generation of Phosphatidylinositol 5-Phosphate

(2008) Matthew W. Bunce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels

(2008) Matthew J. Christians et al.   PLANT JOURNAL

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling

(2008) H.-C. S. Yen et al.   SCIENCE