Regulation of NF-κB by ubiquitination and degradation of the IκBs

It takes two to tango: IκBs, the multifunctional partners of NF-κB

(2012) Michael Hinz et al.   IMMUNOLOGICAL REVIEWS

Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies

(2012) Kian-Huat Lim et al.   IMMUNOLOGICAL REVIEWS

Lessons from mathematically modeling the NF-κB pathway

(2012) Soumen Basak et al.   IMMUNOLOGICAL REVIEWS

Regulation of NF-κB by deubiquitinases

(2012) Edward W. Harhaj et al.   IMMUNOLOGICAL REVIEWS

Structural regulation of cullin-RING ubiquitin ligase complexes

(2011) David M Duda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

CKIα ablation highlights a critical role for p53 in invasiveness control

(2011) Ela Elyada et al.   NATURE

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

(2011) Matthew F Calabrese et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF- B-dependent lymphoma

(2010) M. A. Milhollen et al.   BLOOD

17-DMAG targets the nuclear factor- B family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

(2010) E. Hertlein et al.   BLOOD

Targeting transcription factor NFκB: comparative analysis of proteasome and IKK inhibitors

(2010) Alexander V. Gasparian et al.   CELL CYCLE

Combination Therapy of Bortezomib with Novel Targeted Agents: An Emerging Treatment Strategy

(2010) J. J. Wright   CLINICAL CANCER RESEARCH

Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF -TrCP by single substrate depletion

(2010) N. Kanarek et al.   GENES & DEVELOPMENT

IκBβ acts to inhibit and activate gene expression during the inflammatory response

(2010) Ping Rao et al.   NATURE

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

(2010) Li-Chung Hsu et al.   NATURE IMMUNOLOGY

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates

(2009) Gary Kleiger et al.   CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

NF-κB Inhibition through Proteasome Inhibition or IKKβ Blockade Increases the Susceptibility of Melanoma Cells to Cytostatic Treatment through Distinct Pathways

(2009) Katharina Amschler et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for Proteasomal Processing of the p105 NF-κB Precursor

(2009) Yelena Kravtsova-Ivantsiv et al.   MOLECULAR CELL

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Ubiquitination and Degradation of the Inhibitors of NF- B

(2009) N. Kanarek et al.   Cold Spring Harbor Perspectives in Biology

NF- B in the Nervous System

(2009) B. Kaltschmidt et al.   Cold Spring Harbor Perspectives in Biology

The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint

(2008) Florian Bassermann et al.   CELL

Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy

(2008) D.-F. Lee et al.   CLINICAL CANCER RESEARCH

IL-1, IL-18, and IL-33 families of cytokines

(2008) William P. Arend et al.   IMMUNOLOGICAL REVIEWS

KINK-1, a Novel Small-Molecule Inhibitor of IKKβ, and the Susceptibility of Melanoma Cells to Antitumoral Treatment

(2008) Margarete Schön et al.   JNCI-Journal of the National Cancer Institute

UV as an Amplifier Rather Than Inducer of NF-κB Activity

(2008) Ellen L. O'Dea et al.   MOLECULAR CELL

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

Understanding NF-κB signaling via mathematical modeling

(2008) Raymond Cheong et al.   Molecular Systems Biology

Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor–induced proliferation

(2008) Srividya Sriskantharajah et al.   NATURE IMMUNOLOGY

Introducing Spatial Information into Predictive NF-κB Modelling – An Agent-Based Approach

(2008) Mark Pogson et al.   PLoS One

New insights into NF-κB regulation and function

(2008) Shao-Cong Sun et al.   TRENDS IN IMMUNOLOGY