c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth

c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis

(2019) Chimera L. Lyle et al.   Cells

Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells

(2019) Kankana Bardhan et al.   Scientific Reports

c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/β-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation

(2018) Sowmiya Kumaradevan et al.   AMERICAN JOURNAL OF PATHOLOGY

E3 ubiquitin ligases Cbl-b and c-Cbl downregulate PD-L1 in EGFR wild-type non-small cell lung cancer

(2018) Shuo Wang et al.   FEBS LETTERS

PD-L1+ tumor-associated macrophages and PD-1+ tumor infiltrating lymphocytes predict survival in primary testicular lymphoma

(2018) Marjukka Pollari et al.   HAEMATOLOGICA

PD-L1+ tumor-associated macrophages and PD-1+ tumor infiltrating lymphocytes predict survival in primary testicular lymphoma

(2018) Marjukka Pollari et al.   HAEMATOLOGICA

Targeting Macrophages in Cancer: From Bench to Bedside

(2018) Ashleigh R. Poh et al.   Frontiers in Oncology

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

(2018) Wei Wang et al.   CANCER CELL

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

(2018) Xiangbo Meng et al.   NATURE

Colorectal Cancer Incidence Patterns in the United States, 1974–2013

(2017) Rebecca L. Siegel et al.   JNCI-Journal of the National Cancer Institute

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Ubiquitination and the Regulation of Membrane Proteins

(2017) Natalie Foot et al.   PHYSIOLOGICAL REVIEWS

Colorectal Cancer Incidence Patterns in the United States, 1974–2013

(2017) Rebecca L. Siegel et al.   JNCI-Journal of the National Cancer Institute

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

(2016) Shohei Koyama et al.   Nature Communications

c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors

(2016) Moshe Shashar et al.   Oncotarget

The c-Cbl Ubiquitin Ligase Regulates Nuclear β-Catenin and Angiogenesis by Its Tyrosine Phosphorylation Mediated through the Wnt Signaling Pathway

(2015) Sowmya Shivanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

c-Cbl, a Ubiquitin E3 Ligase That Targets Active β-Catenin

(2013) Vipul Chitalia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases

(2012) Bhopal Mohapatra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

(2010) Charlotte M Niemeyer et al.   NATURE GENETICS

Phagocytosis in Macrophages Lacking Cbl Reveals an Unsuspected Role for Fc  Receptor Signaling and Actin Assembly in Target Binding

(2009) B. M. Dale et al.   JOURNAL OF IMMUNOLOGY

Jade-1 inhibits Wnt signalling by ubiquitylating β-catenin and mediates Wnt pathway inhibition by pVHL

(2008) Vipul C. Chitalia et al.   NATURE CELL BIOLOGY