Squamous cell carcinoma–related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21protein complex during abscission

Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

(2017) Daniel C Scott et al.   Nature Chemical Biology

Squamous Cell Carcinoma-related Oncogene (SCCRO) Family Members Regulate Cell Growth and Proliferation through Their Cooperative and Antagonistic Effects on Cullin Neddylation

(2016) Weimin Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the mammalian family of DCN-type NEDD8 E3 ligases

(2016) Matthew J. Keuss et al.   JOURNAL OF CELL SCIENCE

MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma

(2016) Yi Zhang et al.   Oncotarget

The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia

(2016) Kun Han et al.   Oncotarget

SCCRO3 (DCUN1D3) Antagonizes the Neddylation and Oncogenic Activity of SCCRO (DCUN1D1)

(2014) Guochang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neddylation pathway regulates the proliferation and survival of macrophages

(2013) Lihui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oncogenic Function of SCCRO5/DCUN1D5 Requires Its Neddylation E3 Activity and Nuclear Localization

(2013) C. C. Bommelje et al.   CLINICAL CANCER RESEARCH

Aurora B and Cyclin B Have Opposite Effects on the Timing of Cytokinesis Abscission in Drosophila Germ Cells and in Vertebrate Somatic Cells

(2013) Juliette Mathieu et al.   DEVELOPMENTAL CELL

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase

(2013) P. Heir et al.   MOLECULAR AND CELLULAR BIOLOGY

ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C

(2012) J. G. Carlton et al.   SCIENCE

Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes

(2012) Julie K. Monda et al.   STRUCTURE

Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover

(2011) M. A. Milhollen et al.   CANCER RESEARCH

SCCRO (DCUN1D1) Promotes Nuclear Translocation and Assembly of the Neddylation E3 Complex

(2011) Guochang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and cellular effects of inhibiting Nedd8 conjugation

(2010) Yee Chin Leck et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells

(2010) J. J. Lin et al.   CANCER RESEARCH

A Dual E3 Mechanism for Rub1 Ligation to Cdc53

(2010) Daniel C. Scott et al.   MOLECULAR CELL

The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis

(2009) Sarah Maerki et al.   JOURNAL OF CELL BIOLOGY

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Novel substrates and functions for the ubiquitin-like molecule NEDD8: Figure 1

(2008) Dimitris P. Xirodimas   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

SCCRO (DCUN1D1) Is an Essential Component of the E3 Complex for Neddylation

(2008) Alexander Y. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation

(2008) Thimo Kurz et al.   MOLECULAR CELL

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

E3 ubiquitin ligases and mitosis: embracing the complexity

(2008) Izabela Sumara et al.   TRENDS IN CELL BIOLOGY