Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity

The Bruton tyrosine kinase inhibitor ibrutinib abrogates triggering receptor on myeloid cells 1-mediated neutrophil activation

(2017) Nicole Stadler et al.   HAEMATOLOGICA

Human NACHT, LRR, and PYD domain–containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase

(2017) Xiao Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Analysis of the risk of infection in patients with chronic lymphocytic leukemia in the era of novel therapies

(2017) AnnaLynn M. Williams et al.   LEUKEMIA & LYMPHOMA

The Bruton’s tyrosine kinase inhibitor ibrutinib exerts immunomodulatory effects through regulation of tumor-infiltrating macrophages

(2017) Lingyan Ping et al.   Oncotarget

Transcriptome profiling of monocytes from XLA patients revealed the innate immune function dysregulation due to the BTK gene expression deficiency

(2017) Hoda Mirsafian et al.   Scientific Reports

The Bruton tyrosine kinase inhibitor ibrutinib abrogates triggering receptor on myeloid cells 1-mediated neutrophil activation

(2017) Nicole Stadler et al.   HAEMATOLOGICA

The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement

(2017) Filomena Monica Cavaliere et al.   PLoS One

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation

(2016) Stephanie Volmering et al.   IMMUNITY

c-Src Suppresses Dendritic Cell Antitumor Activity via T Cell Ig and Mucin Protein-3 Receptor

(2016) Ravindra Gujar et al.   JOURNAL OF IMMUNOLOGY

A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation

(2016) E Grassilli et al.   ONCOGENE

Preclinical investigation of ibrutinib, a Bruton’s kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes

(2016) Li Wei et al.   Oncotarget

A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells

(2016) Gayathri Natarajan et al.   OncoImmunology

The Inflammasomes and Autoinflammatory Syndromes

(2015) Lori Broderick et al.   Annual Review of Pathology-Mechanisms of Disease

Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer

(2015) Leila Kokabee et al.   CANCER BIOLOGY & THERAPY

Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus

(2015) S. Herbst et al.   EMBO Molecular Medicine

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma

(2015) Wyndham H Wilson et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

(2015) A. J. Gunderson et al.   Cancer Discovery

Ibrutinib enhances IL-17 response by modulating the function of bone marrow derived dendritic cells

(2015) Gayathri Natarajan et al.   OncoImmunology

Bruton tyrosine kinase mediates TLR9-dependent human dendritic cell activation

(2014) Vassilios Lougaris et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Etk/BMX, a Btk Family Tyrosine Kinase, and Mal Contribute to the Cross-Talk between MyD88 and FAK Pathways

(2014) N. Semaan et al.   JOURNAL OF IMMUNOLOGY

Dual Functions of Bruton's Tyrosine Kinase and Tec Kinase during Fc  Receptor-Induced Signaling and Phagocytosis

(2014) J. Jongstra-Bilen et al.   JOURNAL OF IMMUNOLOGY

Essential Roles for the Tec Family Kinases Tec and Btk in M-CSF Receptor Signaling Pathways That Regulate Macrophage Survival

(2014) M. Melcher et al.   JOURNAL OF IMMUNOLOGY

Immunoregulation of Dendritic Cells by the Receptor T cell Ig and Mucin Protein-3 via Bruton’s Tyrosine Kinase and c-Src

(2014) Neeraj Maurya et al.   JOURNAL OF IMMUNOLOGY

Ibrutinib inhibits collagen-mediated but not ADP-mediated platelet aggregation

(2014) S Kamel et al.   LEUKEMIA

Bruton's Tyrosine Kinase and Protein Kinase C µ Are Required for TLR7/9-Induced IKKα and IRF-1 Activation and Interferon-β Production in Conventional Dendritic Cells

(2014) Yan-Feng Li et al.   PLoS One

A novel isoform of the B cell tyrosine kinase BTK protects breast cancer cells from apoptosis

(2013) Cheryl Eifert et al.   GENES CHROMOSOMES & CANCER

The Tyrosine Kinase Btk Regulates the Macrophage Response to Listeria monocytogenes Infection

(2013) Afitap Derya Köprülü et al.   PLoS One

The B-cell receptor signaling pathway as a therapeutic target in CLL

(2012) J. A. Woyach et al.   BLOOD

Tyrosine Kinase Btk Is Required for NK Cell Activation

(2012) Yan Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils

(2012) Fumiko Honda et al.   NATURE IMMUNOLOGY

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

(2012) K.-G. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Btk is a positive regulator in the TREM-1/DAP12 signaling pathway

(2011) T. Ormsby et al.   BLOOD

Toll-like receptor 4–, 7–, and 8–activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines

(2011) Thomas U. Marron et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Novel Role for Bruton's Tyrosine Kinase in Hepatocyte Growth Factor-mediated Immunoregulation of Dendritic Cells

(2011) Eshu Singhal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bruton's Tyrosine Kinase Is Required for TLR-Dependent Heme Oxygenase-1 Gene Activation via Nrf2 in Macrophages

(2011) V. Vijayan et al.   JOURNAL OF IMMUNOLOGY

Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia

(2010) K. Fiedler et al.   BLOOD

TLR signaling and effector functions are intact in XLA neutrophils

(2010) Thomas U. Marron et al.   CLINICAL IMMUNOLOGY

Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis

(2010) Julie A Di Paolo et al.   Nature Chemical Biology

Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia

(2007) Hiromichi Taneichi et al.   CLINICAL IMMUNOLOGY