The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine Receptors—A Review of Literature

Upregulated CXCL14 is associated with poor survival outcomes and promotes ovarian cancer cells proliferation

(2020) Xue Li et al.   CELL BIOCHEMISTRY AND FUNCTION

Hypoxia upregulates Cxcl12 in hepatocytes by a complex mechanism involving hypoxia-inducible factors and transforming growth factor-β

(2020) Jenna Strickland et al.   CYTOKINE

Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway

(2020) Victor Delprat et al.   Scientific Reports

Chemokines and their Receptors: Multifaceted Roles in Cancer Progression and Potential Value as Cancer Prognostic Markers

(2020) Ha Thi Thu Do et al.   Cancers

Inhibition of GPR35 Preserves Mitochondrial Function after Myocardial Infarction by Targeting Calpain 1/2

(2020) Ken Chen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial

(2020) Bruno Bockorny et al.   NATURE MEDICINE

Possibility of cancer-stem-cell-targeted radioimmunotherapy for acute myelogenous leukemia using 211At-CXCR4 monoclonal antibody

(2020) Noboru Oriuchi et al.   Scientific Reports

Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti–PD-L1 immunotherapy

(2020) Zhaoting Li et al.   Science Advances

Bone mesenchymal stem cells are recruited via CXCL8‐CXCR2 and promote EMT through TGF‐β signal pathways in oral squamous carcinoma

(2020) Lin Meng et al.   CELL PROLIFERATION

CXCL10 mediates breast cancer tamoxifen resistance and promotes estrogen-dependent and independent proliferation

(2020) Xiuming Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effect of chemokine CXCL14 on in vitro angiogenesis of human hepatocellular carcinoma cells

(2020) Yuanguang Liu et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer

(2020) Crescenzo D’Alterio et al.   Cancers

CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway

(2020) Chih-Lun Cheng et al.   Cells

CXCR4 Antagonist AMD3100 Reverses the Resistance to Tamoxifen in Breast Cancer via Inhibiting AKT Phosphorylation

(2020) Jun Zhou et al.   Molecular Therapy-Oncolytics

CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells

(2019) C. Tulotta et al.   Scientific Reports

Cancer-associated fibroblasts enhance tumor-associated macrophages enrichment and suppress NK cells function in colorectal cancer

(2019) Rongsheng Zhang et al.   Cell Death & Disease

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4+ T-Cell–Dependent Control of Senescence

(2019) Jana C. Mossanen et al.   GASTROENTEROLOGY

Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation

(2019) Nahyeon Kang et al.   BMC CANCER

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

(2019) Najah Albadari et al.   Expert Opinion on Drug Discovery

RELA promotes hypoxia‐induced angiogenesis in human umbilical vascular endothelial cells via LINC01693/miR‐302d/CXCL12 axis

(2019) Yang Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transcriptional regulation of FoxM1 by HIF‑1α mediates hypoxia‑induced EMT in prostate cancer

(2019) Cong Tang et al.   ONCOLOGY REPORTS

Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment

(2019) Xiao-Jing Chen et al.   Cell Death & Disease

The safety and efficacy of anti-PD-1/anti-PD-L1 antibody therapy in the treatment of previously treated, advanced gastric or gastro-oesophageal junction cancer: A meta-analysis of prospective clinical trials

(2019) Xiaofei Ni et al.   Clinics and Research in Hepatology and Gastroenterology

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment

(2019) Reynders et al.   Cells

Anti-CXCR4 Antibody Combined With Activated and Expanded Natural Killer Cells for Sarcoma Immunotherapy

(2019) Maria Vela et al.   Frontiers in Immunology

Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors

(2019) Marijo Bilusic et al.   Journal for ImmunoTherapy of Cancer

Role of CXCR3 signaling in response to anti-PD-1 therapy

(2019) Xiao Han et al.   EBioMedicine

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

(2019) Yoram Vodovotz et al.   Annals of Translational Medicine

CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction

(2019) Joji Kusuyama et al.   BIOCHEMICAL JOURNAL

Hypoxia modifies the polarization of macrophages and their inflammatory microenvironment, and inhibits malignant behavior in cancer cells

(2019) Xixian Ke et al.   Oncology Letters

Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow

(2019) Ryo Takahashi et al.   BIOMEDICINE & PHARMACOTHERAPY

Blocking migration of regulatory T cells to leukemic hematopoietic microenvironment delays disease progression in mouse leukemia model

(2019) Rong Wang et al.   CANCER LETTERS

Hypoxia induced Sonic Hedgehog signaling regulates cancer stemness, epithelial-to-mesenchymal transition and invasion in cholangiocarcinoma

(2019) Vikas Bhuria et al.   EXPERIMENTAL CELL RESEARCH

PHD2 exerts anti-cancer and anti-inflammatory effects in colon cancer xenografts mice via attenuating NF-κB activity

(2019) Li Wang et al.   LIFE SCIENCES

Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor

(2019) Bao-Hua Li et al.   MOLECULAR IMMUNOLOGY

Selective inhibition of endothelial NF-κB signaling attenuates chronic intermittent hypoxia-induced atherosclerosis in mice

(2018) Dongmei Song et al.   ATHEROSCLEROSIS

HIF-1α induces immune escape of prostate cancer by regulating NCR1/NKp46 signaling through miR-224

(2018) Chao-hao Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CXCR4 antagonist AMD3100 enhances the response of MDA-MB-231 triple-negative breast cancer cells to ionizing radiation

(2018) K.X. Zhou et al.   CANCER LETTERS

Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge

(2018) Sho Koyasu et al.   CANCER SCIENCE

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

(2018) Xianmin Mu et al.   CELL CYCLE

HIF-1α promotes the migration and invasion of hepatocellular carcinoma cells via the IL-8–NF-κB axis

(2018) Wenming Feng et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis

(2018) Min Li et al.   GENE

Enzalutamide and CXCR7 inhibitor combination treatment suppresses cell growth and angiogenic signaling in castration-resistant prostate cancer models

(2018) Yong Luo et al.   INTERNATIONAL JOURNAL OF CANCER

Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35

(2018) Nurul A. S. Binti Mohd Amir et al.   JOURNAL OF IMMUNOLOGY

SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP‑2

(2018) Meng Xu et al.   ONCOLOGY REPORTS

Tumor-associated macrophages promote the metastasis of ovarian carcinoma cells by enhancing CXCL16/CXCR6 expression

(2018) Lan Hong et al.   PATHOLOGY RESEARCH AND PRACTICE

HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice

(2018) Claire-Sophie Devignes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells

(2018) S. Jamaludin et al.   Oncology Letters

Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation

(2018) Mana Taki et al.   Nature Communications

Hypoxia enhances indoleamine 2,3-dioxygenase production in dendritic cells

(2018) Xiang Song et al.   Oncotarget

Rat astrocytes during anoxia: Secretome profile of cytokines and chemokines

(2018) Zeinab Adel Samy et al.   Brain and Behavior

Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells

(2018) Xian Wu et al.   Advanced Science

Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy

(2018) Yiliang Li et al.   Frontiers in Immunology

Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines

(2018) Edmund K. Moon et al.   OncoImmunology

Bone marrow-derived CXCR4-overexpressing MSCs display increased homing to intestine and ameliorate colitis-associated tumorigenesis in mice

(2018) Xiao-Bin Zheng et al.   Gastroenterology Report

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CXCL1 and CXCL2 produced by tumor promote the generation of monocytic myeloid-derived suppressor cells

(2018) Huifang Shi et al.   CANCER SCIENCE

Hypoxia promotes the migration and invasion of human hepatocarcinoma cells through the HIF-1α–IL-8–Akt axis

(2018) Maoyun Fei et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Selective depletion of metastatic stem cells as therapy for human colorectal cancer

(2018) María Virtudes Céspedes et al.   EMBO Molecular Medicine

Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma

(2018) Khalid Amine Timani et al.   Molecular Cancer

A feed-forward loop between nuclear translocation of CXCR4 and HIF-1α promotes renal cell carcinoma metastasis

(2018) Yi Bao et al.   ONCOGENE

Arylsulfonamide 64B inhibits hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma

(2018) Erwin G. Van Meir et al.   CLINICAL CANCER RESEARCH

The use of cobalt chloride as a chemical hypoxia model

(2018) Jorge Muñoz-Sánchez et al.   JOURNAL OF APPLIED TOXICOLOGY

HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk

(2018) Yingying Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Gregory A Roth et al.   LANCET

Non-platelet-derived CXCL4 differentially regulates cytotoxic and regulatory T cells through CXCR3 to suppress the immune response to colon cancer

(2018) Shaorong Deng et al.   CANCER LETTERS

CXCR4 targeted dendrimer for anti-cancer drug delivery and breast cancer cell migration inhibition

(2017) Chuda Chittasupho et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells

(2017) Tomonori Oka et al.   JOURNAL OF IMMUNOLOGY

Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer

(2017) Shih-Chieh Lin et al.   JOURNAL OF PATHOLOGY

Papillary renal cell carcinoma-derived chemerin, IL-8, and CXCL16 promote monocyte recruitment and differentiation into foam-cell macrophages

(2017) Krzysztof M Krawczyk et al.   LABORATORY INVESTIGATION

Bevacizumab and paclitaxel–carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial

(2017) Robert L Coleman et al.   LANCET ONCOLOGY

Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population

(2017) K. Mahkamova et al.   WORLD JOURNAL OF SURGERY

Opposite response to hypoxia by breast cancer cells between cell proliferation and cell migration: A clue from microRNA expression profile

(2017) Ming Zhang et al.   Oncology Letters

Survival benefit of glioblastoma patients after FDA approval of temozolomide concomitant with radiation and bevacizumab: A population-based study

(2017) Ping Zhu et al.   Oncotarget

CXCL13 is androgen-responsive and involved in androgen induced prostate cancer cell migration and invasion

(2017) Long Fan et al.   Oncotarget

Targeting CXCR4 reverts the suppressive activity of T-regulatory cells in renal cancer

(2017) Sara Santagata et al.   Oncotarget

A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke

(2017) Hsu-Tung Lee et al.   Theranostics

Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice

(2017) Zixi Hu et al.   Theranostics

Role of tumor microenvironment in tumorigenesis

(2017) Maonan Wang et al.   Journal of Cancer

Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction

(2017) Manja Idorn et al.   OncoImmunology

Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer

(2017) Xiaowei Chen et al.   OncoImmunology

Genetic engineering of human NK cells to express CXCR2 improves migration to renal cell carcinoma

(2017) Veronika Kremer et al.   Journal for ImmunoTherapy of Cancer

CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity

(2017) Kosuke Tanegashima et al.   EBioMedicine

Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression

(2017) Jie Qin et al.   Scientific Reports

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways

(2017) Karim Ullah et al.   Scientific Reports

CXCL1–Chemokine (C-X-C Motif) Receptor 2 Signaling Stimulates the Recruitment of Bone Marrow–Derived Mesenchymal Cells into Diffuse-Type Gastric Cancer Stroma

(2016) Hiroaki Kasashima et al.   AMERICAN JOURNAL OF PATHOLOGY

HIF-1  regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment

(2016) R. Valsecchi et al.   BLOOD

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

VEGF expression is regulated by HIF-1α and ARNT in 3D KYSE-70, esophageal cancer cell spheroids

(2016) Jun Terashima et al.   CELL BIOLOGY INTERNATIONAL

“Inverse signaling” of the transmembrane chemokine CXCL16 contributes to proliferative and anti-apoptotic effects in cultured human meningioma cells

(2016) Kirsten Hattermann et al.   Cell Communication and Signaling

Hypoxia/ischemia promotes CXCL10 expression in cardiac microvascular endothelial cells by NFkB activation

(2016) Jing-Bo Xia et al.   CYTOKINE

Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells

(2016) Katrin Gutsche et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nanotherapy silencing the interleukin-8 gene produces regression of prostate cancer by inhibition of angiogenesis

(2016) Ravikumar Aalinkeel et al.   IMMUNOLOGY

A simple method to induce hypoxia-induced vascular endothelial growth factor-A (VEGF-A) expression in T24 human bladder cancer cells

(2016) Jonas Magno Santos Cesário et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Repertaxin, an inhibitor of the chemokine receptors CXCR1 and CXCR2, inhibits malignant behavior of human gastric cancer MKN45 cells in vitro and in vivo and enhances efficacy of 5-fluorouracil

(2016) JUNPU WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Antitumor Effect of IP-10 by Using Two Different Approaches: Live Delivery System and Gene Therapy

(2016) Yasaman Taslimi et al.   Journal of Breast Cancer

CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation

(2016) Chang Xian Li et al.   JOURNAL OF HEPATOLOGY

Hypoxia promotes the invasion and metastasis of laryngeal cancer cells via EMT

(2016) Jianhong Zuo et al.   MEDICAL ONCOLOGY

Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils

(2016) Daniel Triner et al.   MOLECULAR AND CELLULAR BIOLOGY

A New Anti-CXCR4 Antibody That Blocks the CXCR4/SDF-1 Axis and Mobilizes Effector Cells

(2016) M. Broussas et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1

(2016) John W. Bullen et al.   Science Signaling

A Chemokine Receptor, CXCR4, Which Is Regulated by Hypoxia-Inducible Factor 2α, Is Crucial for Functional Endothelial Progenitor Cells Migration to Ischemic Tissue and Wound Repair

(2016) Tran Cam Tu et al.   STEM CELLS AND DEVELOPMENT

Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14

(2016) Louis Cicchini et al.   mBio

Hypoxia-NOTCH1-SOX2 signaling is important for maintaining cancer stem cells in ovarian cancer

(2016) Eun Jin Seo et al.   Oncotarget

Hypoxia induced CCL28 promotes angiogenesis in lung adenocarcinoma by targeting CCR3 on endothelial cells

(2016) Guichun Huang et al.   Scientific Reports

Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1

(2016) John W. Bullen et al.   Science Signaling

CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma

(2016) T. Chao et al.   Cancer Immunology Research

Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils

(2016) Ming Yuan et al.   Journal of Immunology Research

HIF2α is involved in the expansion of CXCR4-positive cancer stem-like cells in renal cell carcinoma

(2015) Carla Micucci et al.   BRITISH JOURNAL OF CANCER

The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell

(2015) Feng Xie et al.   CANCER LETTERS

The HIF-1α/CXCR4 pathway supports hypoxia-induced metastasis of human osteosarcoma cells

(2015) Guofeng Guan et al.   CANCER LETTERS

Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210

(2015) Muhammad Zaeem Noman et al.   CANCER RESEARCH

Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis

(2015) Hideyuki Konishi et al.   CANCER SCIENCE

Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments

(2015) Haruhito Kinoshita et al.   CARCINOGENESIS

CXCL7-induced macrophage infiltration in lung tumor is independent of CXCR2 expression

(2015) Nese Unver et al.   CYTOKINE

Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy

(2015) I. Spinello et al.   HAEMATOLOGICA

First-in-Human Experience of CXCR4-Directed Endoradiotherapy with 177Lu- and 90Y-Labeled Pentixather in Advanced-Stage Multiple Myeloma with Extensive Intra- and Extramedullary Disease

(2015) K. Herrmann et al.   JOURNAL OF NUCLEAR MEDICINE

Cycling hypoxia induces chemoresistance through the activation of reactive oxygen species-mediated B-cell lymphoma extra-long pathway in glioblastoma multiforme

(2015) Wei-Ling Chen et al.   Journal of Translational Medicine

The Transcription Factor ZNF395 Is Required for the Maximal Hypoxic Induction of Proinflammatory Cytokines in U87-MG Cells

(2015) Christine Herwartz et al.   MEDIATORS OF INFLAMMATION

Tip110 Regulates the Cross Talk between p53 and Hypoxia-Inducible Factor 1α under Hypoxia and Promotes Survival of Cancer Cells

(2015) Khalid Amine Timani et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis

(2015) X. Sun et al.   MOLECULAR CANCER RESEARCH

CXCL16 induces angiogenesis in autocrine signaling pathway involving hypoxia-inducible factor 1α in human umbilical vein endothelial cells

(2015) XIAOWEN YU et al.   ONCOLOGY REPORTS

Biology of Hypoxia

(2015) Paul N. Span et al.   SEMINARS IN NUCLEAR MEDICINE

HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models

(2015) Yun Hyun Huh et al.   ARTHRITIS RESEARCH & THERAPY

Hypoxia promotes C-X-C chemokine receptor type 4 expression through microRNA-150 in pancreatic cancer cells

(2015) JIN-SHAN SUN et al.   Oncology Letters

Combining CXCL10 gene therapy and radiotherapy improved therapeutic efficacy in cervical cancer HeLa cell xenograft tumor models

(2015) MING ZHAO et al.   Oncology Letters

Temporal regulation of HIF-1 and NF-κB in hypoxic hepatocarcinoma cells

(2015) Yuan Jiang et al.   Oncotarget

Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy

(2015) I. Spinello et al.   HAEMATOLOGICA

Cycling Hypoxia Induces a Specific Amplified Inflammatory Phenotype in Endothelial Cells and Enhances Tumor-Promoting Inflammation In Vivo

(2015) Céline Tellier et al.   NEOPLASIA

Tumor stroma and chemokines control T-cell migration into melanoma following Temozolomide treatment

(2015) Kar Wai Tan et al.   OncoImmunology

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

(2015) Chakrapani Tripathi et al.   Oncotarget

CXCL4L1 and CXCL4 signaling in human lymphatic and microvascular endothelial cells and activated lymphocytes: involvement of mitogen-activated protein (MAP) kinases, Src and p70S6 kinase

(2014) Katrien Van Raemdonck et al.   ANGIOGENESIS

Divergent roles of CXCR3 isoforms in promoting cancer stem-like cell survival and metastasis

(2014) Yanchun Li et al.   BREAST CANCER RESEARCH AND TREATMENT

HIF-1a Plays a Role in the Chemotactic Migration of Hepatocarcinoma Cells Through the Modulation of CXCL6 Expression

(2014) Hui Tian et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MicroRNA Regulates Vascular Endothelial Growth Factor Expression in Chondrosarcoma Cells

(2014) Xiaojuan Sun et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

CXCL14 is no direct modulator of CXCR4

(2014) Maik Otte et al.   FEBS LETTERS

Inhibition of dual specificity phosphatase-2 by hypoxia promotes interleukin-8-mediated angiogenesis in endometriosis

(2014) Kuei-Yang Hsiao et al.   HUMAN REPRODUCTION

MicroRNA-155 deficiency enhances the recruitment and functions of myeloid-derived suppressor cells in tumor microenvironment and promotes solid tumor growth

(2014) Junfeng Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Cutting Edge: GPR35/CXCR8 Is the Receptor of the Mucosal Chemokine CXCL17

(2014) José L. Maravillas-Montero et al.   JOURNAL OF IMMUNOLOGY

The Association of CXCR3 and Renal Cell Carcinoma Metastasis

(2014) Takanobu Utsumi et al.   JOURNAL OF UROLOGY

Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer

(2014) Benoît Romain et al.   Molecular Cancer

miR141-CXCL1-CXCR2 Signaling-Induced Treg Recruitment Regulates Metastases and Survival of Non-Small Cell Lung Cancer

(2014) M. Lv et al.   MOLECULAR CANCER THERAPEUTICS

Expression and effect of CXCL14 in colorectal carcinoma

(2014) KEZHI LIN et al.   Molecular Medicine Reports

A comparative encyclopedia of DNA elements in the mouse genome

(2014) Feng Yue et al.   NATURE

Hypoxia Promotes Migration and Induces CXCR4 Expression via HIF-1α Activation in Human Osteosarcoma

(2014) Mingjun Guo et al.   PLoS One

The Role of Factor Inhibiting HIF (FIH-1) in Inhibiting HIF-1 Transcriptional Activity in Glioblastoma Multiforme

(2014) Enfeng Wang et al.   PLoS One

Distinct Phenotypes of Human Prostate Cancer Cells Associate with Different Adaptation to Hypoxia and Pro-Inflammatory Gene Expression

(2014) Linda Ravenna et al.   PLoS One

Global Gene Expression Profiling in Three Tumor Cell Lines Subjected to Experimental Cycling and Chronic Hypoxia

(2014) Magdalena Olbryt et al.   PLoS One

Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

(2014) M. Ammirante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

(2014) P. Chaturvedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological characteristics of prostate cancer cells are regulated by hypoxia-inducible factor 1α

(2014) XIANG HUANG et al.   Oncology Letters

Chemokine (C-X-C motif) receptor 4 RNA interference inhibits bone metastasis in breast cancer

(2014) HENG ZENG et al.   Oncology Letters

Effect of Hypoxic Stress on Migration and Characteristics of Monocytes in Uveal Melanoma

(2014) Inge H. G. Bronkhorst et al.   JAMA Ophthalmology

CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α

(2013) Mine Esencay et al.   BMC CANCER

Specific Recruitment of    Regulatory T Cells in Human Breast Cancer

(2013) J. Ye et al.   CANCER RESEARCH

Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling

(2013) Veli-Pekka Ronkainen et al.   CARDIOVASCULAR RESEARCH

Int6/eIF3e silenced HIF2α stabilization enhances migration and tube formation of HUVECs via IL-6 and IL-8 signaling

(2013) Alexander Endler et al.   CYTOKINE

Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC

(2013) Mirna Balsamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis

(2013) Kosuke Tanegashima et al.   FEBS LETTERS

The effects of intermittent hypoxia on redox status, NF-κB activation, and plasma lipid levels are dependent on the lowest oxygen saturation

(2013) Miguel Quintero et al.   FREE RADICAL BIOLOGY AND MEDICINE

CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-β

(2013) J. Jablonska et al.   INTERNATIONAL JOURNAL OF CANCER

HAF drives the switch of HIF-1α to HIF-2α by activating the NF-κB pathway, leading to malignant behavior of T24 bladder cancer cells

(2013) ZHENFENG GUAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

(2013) P Storti et al.   LEUKEMIA

Hypoxia Stimulates the EMT of Gastric Cancer Cells through Autocrine TGFβ Signaling

(2013) Junko Matsuoka et al.   PLoS One

High-level expression of CXCR4 in breast cancer is associated with early distant and bone metastases

(2013) Chin-Sheng Hung et al.   TUMOR BIOLOGY

Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis

(2013) Younghun Jung et al.   Nature Communications

CXCR6 and CCR5 Localize T Lymphocyte Subsets in Nasopharyngeal Carcinoma

(2012) Greg Parsonage et al.   AMERICAN JOURNAL OF PATHOLOGY

CXCL17, an orphan chemokine, acts as a novel angiogenic and anti-inflammatory factor

(2012) Wei-Yu Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

CXCR3+ T Regulatory Cells Selectively Accumulate in Human Ovarian Carcinomas to Limit Type I Immunity

(2012) N. Redjimi et al.   CANCER RESEARCH

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

(2012) Norma Masson et al.   EMBO REPORTS

The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells

(2012) Fabiola Blengio et al.   IMMUNOBIOLOGY

pO2 Fluctuation Pattern and Cycling Hypoxia in Human Cervical Carcinoma and Melanoma Xenografts

(2012) Christine Ellingsen et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia enhances colon cancer migration and invasion through promotion of epithelial-mesenchymal transition

(2012) Kumiko Hongo et al.   JOURNAL OF SURGICAL RESEARCH

New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation

(2012) F. Jin et al.   MOLECULAR CANCER RESEARCH

Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model

(2012) JI-YE KEE et al.   ONCOLOGY REPORTS

Hypoxia induces CXCR4 expression and biological activity in gastric cancer cells through activation of hypoxia-inducible factor-1α

(2012) YOON SUK OH et al.   ONCOLOGY REPORTS

Hyperbaric oxygen therapy and cancer—a review

(2012) Ingrid Moen et al.   Targeted Oncology

Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism

(2011) Melanie J Voss et al.   BMC CANCER

In Vivo Profiling of Hypoxic Gene Expression in Gliomas Using the Hypoxia Marker EF5 and Laser-capture Microdissection

(2011) D. Marotta et al.   CANCER RESEARCH

Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells

(2011) Urszula Florczyk et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model

(2011) Shu-Chi Wang et al.   LABORATORY INVESTIGATION

Apparent PKA activity responds to intermittent hypoxia in bone cells: a redox pathway?

(2010) Yan-Liang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Molecular Pathways of Spontaneous and TNF-α–Mediated Neutrophil Apoptosis under Intermittent Hypoxia

(2010) Larissa Dyugovskaya et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

NF-κB suppresses HIF-1α response by competing for P300 binding

(2010) Daniela B.S. Mendonça et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches

(2010) I. G. Winkler et al.   BLOOD

Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4

(2010) Patricia A Cronin et al.   BMC CANCER

Up-regulation of pro-inflammatory genes as adaptation to hypoxia in MCF-7 cells and in human mammary invasive carcinoma microenvironment

(2010) Marco Tafani et al.   CANCER SCIENCE

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Hypoxia stimulates CXCR4 signalling in ileal carcinoids

(2010) Yvonne Arvidsson et al.   ENDOCRINE-RELATED CANCER

HIF-1α signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells

(2010) Viktor Malec et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxp3+ IL-17+ T cells promote development of cancer-initiating cells in colorectal cancer

(2010) Shaobo Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanism of Hypoxia-Induced NF- B

(2010) C. Culver et al.   MOLECULAR AND CELLULAR BIOLOGY

CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression

(2010) Xiaojuan Sun et al.   Molecular Cancer

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Alterations in VHL as potential biomarkers in renal-cell carcinoma

(2010) Lucy Gossage et al.   Nature Reviews Clinical Oncology

Chemokines mediate mesenchymal stem cell migration toward gliomas in vitro

(2010) Xu   ONCOLOGY REPORTS

Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity

(2010) Hsieh   ONCOLOGY REPORTS

Intermittent and sustained hypoxia induce a similar gene expression profile in human aortic endothelial cells

(2010) Vsevolod Y. Polotsky et al.   PHYSIOLOGICAL GENOMICS

Up-regulation of the Pro-inflammatory Chemokine CXCL16 is a Common Response of Tumor Cells to Ionizing Radiation

(2010) Satoko Matsumura et al.   RADIATION RESEARCH

HIF-1 Induction Attenuates Nrf2-Dependent IL-8 Expression in Human Endothelial Cells

(2009) Agnieszka Loboda et al.   ANTIOXIDANTS & REDOX SIGNALING

STAT1 represses hypoxia-inducible factor-1-mediated transcription

(2009) Miki Hiroi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

Chemokine C–X–C motif receptor 6 contributes to cell migration during hypoxia

(2009) Sensen Lin et al.   CANCER LETTERS

Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1α

(2009) Dong Hoon Shin et al.   FEBS Journal

Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells

(2009) S. K. Martin et al.   HAEMATOLOGICA

Selective upregulation of interleukin-8 by human rhabdomyosarcomas in response to hypoxia: therapeutic implications

(2009) Marcin Wysoczynski et al.   INTERNATIONAL JOURNAL OF CANCER

Stromal cell-derived factor-1 expression in pituitary adenoma tissues and upregulation in hypoxia

(2009) Ryutaro Nomura et al.   JOURNAL OF NEURO-ONCOLOGY

Hepatocyte growth factor induces hypoxia-related interleukin-8 expression in lung adenocarcinoma cells

(2009) Yung-Yen Chiang   MOLECULAR CARCINOGENESIS

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

CXCR4 Expression in Early Breast Cancer and Risk of Distant Recurrence

(2009) F. Andre et al.   ONCOLOGIST

Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

(2009) Lauren K. Dunn et al.   PLoS One

CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth

(2009) M. Augsten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic Trapping of CXCR4 in Hepatocellular Carcinoma Cell Lines

(2009) Seong-Woo Kim et al.   Cancer Research and Treatment

Hypoxia- and Vascular Endothelial Growth Factor-Induced Stromal Cell-Derived Factor-1α/CXCR4 Expression in Glioblastomas

(2008) David Zagzag et al.   AMERICAN JOURNAL OF PATHOLOGY

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure

(2008) M. Fiegl et al.   BLOOD

Comparison of angiogenesis-related factor expression in primary tumor cultures under normal and hypoxic growth conditions

(2008) Jamie M Heinzman et al.   Cancer Cell International

The Pervasive Presence of Fluctuating Oxygenation in Tumors

(2008) L. I. Cardenas-Navia et al.   CANCER RESEARCH

Induction of HIF-1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+signaling, prolyl hydroxylases, and mTOR

(2008) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3

(2008) A. Mueller et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neural Stem Cell Tropism to Glioma: Critical Role of Tumor Hypoxia

(2008) D. Zhao et al.   MOLECULAR CANCER RESEARCH

PHDs overactivation during chronic hypoxia "desensitizes" HIF  and protects cells from necrosis

(2008) A. Ginouves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Cells Enhance Tumor Cell Invasion through a Crosstalk Mediated by CXC Chemokine Signaling

(2008) Kristy A. Warner et al.   NEOPLASIA