HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53

(2018) Anette Szczepny et al.   ONCOGENE

HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition

(2017) Mingang Hao et al.   JOURNAL OF PATHOLOGY

Up-regulation of chemokine receptor CCR4 is associated with Human Hepatocellular Carcinoma malignant behavior

(2017) Xi Cheng et al.   Scientific Reports

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

Expression of the chemokine CXCL14 in the tumour stroma is an independent marker of survival in breast cancer

(2016) Elin Sjöberg et al.   BRITISH JOURNAL OF CANCER

HIC1 and miR-23~27~24 clusters form a double-negative feedback loop in breast cancer

(2016) Yanbo Wang et al.   CELL DEATH AND DIFFERENTIATION

Tumor-associated macrophage or chemokine ligand CCL17 positively regulates the tumorigenesis of hepatocellular carcinoma

(2016) Fangyu Zhu et al.   MEDICAL ONCOLOGY

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

(2016) Alexandra Avgustinova et al.   Nature Communications

Hypermethylated in cancer 1(HIC1) suppresses non-small cell lung cancer progression by targeting interleukin-6/Stat3 pathway

(2016) Xiumin Wang et al.   Oncotarget

IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling

(2015) Jinchang Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

(2015) Maria-Giuseppina Procopio et al.   NATURE CELL BIOLOGY

Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice

(2015) Ryu-Ichiro Hata et al.   Scientific Reports

Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics

(2015) Nancy Dumont et al.   NEOPLASIA

Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer

(2014) Lihui Li et al.   JNCI-Journal of the National Cancer Institute

The Neddylation-Cullin 2-RBX1 E3 Ligase Axis Targets Tumor Suppressor RhoB for Degradation in Liver Cancer

(2014) Junfeng Xu et al.   MOLECULAR & CELLULAR PROTEOMICS

HIC1 Silencing in Triple-Negative Breast Cancer Drives Progression through Misregulation of LCN2

(2013) G. Cheng et al.   CANCER RESEARCH

HIC1 Modulates Prostate Cancer Progression by Epigenetic Modification

(2013) J. Zheng et al.   CLINICAL CANCER RESEARCH

CCR4 mediates CCL17 (TARC)-induced migration of human colon cancer cells via RhoA/Rho-kinase signaling

(2013) Amr A. Al-haidari et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Wnt-Signalling in the Embryonic Mammary Gland

(2013) Kata Boras-Granic et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Expression of CXCL14 and its anticancer role in breast cancer

(2012) Xiao-Li Gu et al.   BREAST CANCER RESEARCH AND TREATMENT

The chemokine receptor CCR4 promotes tumor growth and lung metastasis in breast cancer

(2011) Ji-Yu Li et al.   BREAST CANCER RESEARCH AND TREATMENT

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment

(2011) Casey Trimmer et al.   CANCER BIOLOGY & THERAPY

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

(2011) Jingqi Chen et al.   CANCER CELL

Generation of two modified mouse alleles of the Hic1 tumor suppressor gene

(2011) Vendula Pospichalova et al.   GENESIS

Loss of Hypermethylated in Cancer 1 (HIC1) in Breast Cancer Cells Contributes to Stress-induced Migration and Invasion through β-2 Adrenergic Receptor (ADRB2) Misregulation

(2011) Gaylor Boulay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

(2010) Yi Arial Zeng et al.   Cell Stem Cell

A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1

(2010) W Zhang et al.   ONCOGENE

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells

(2009) P. B. Olkhanud et al.   CANCER RESEARCH

Scavenger Chemokine (CXC Motif) Receptor 7 (CXCR7) Is a Direct Target Gene ofHIC1(Hypermethylated in Cancer 1)

(2009) Capucine Van Rechem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

(2008) Adam W. Studebaker et al.   CANCER RESEARCH

Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors

(2008) G. Trimis et al.   HUMAN MOLECULAR GENETICS

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia

(2008) M. Matsumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA