Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge

Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma

(2017) Meiying Ji et al.   Oncology Letters

Dual-negative expression of Nrf2 and NQO1 predicts superior outcomes in patients with non-small cell lung cancer

(2017) Ying-Hui Tong et al.   Oncotarget

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

(2017) Ryota Nakashima et al.   Scientific Reports

Regulation of HIF-1α stability by lysine methylation

(2016) Sung Hee Baek et al.   BMB Reports

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

(2016) Stephen P. Burr et al.   Cell Metabolism

Nuclear respiratory factor-1 (NRF-1) regulated hypoxia-inducible factor-1α (HIF-1α) under hypoxia in HEK293T

(2016) Dan Wang et al.   IUBMB LIFE

Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance

(2016) Hiroshi Harada   JOURNAL OF RADIATION RESEARCH

NQO1 inhibits proteasome-mediated degradation of HIF-1α

(2016) Eun-Taex Oh et al.   Nature Communications

Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

(2016) Yunho Kim et al.   Nature Communications

LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis

(2016) Chan Joo Yeom et al.   Oncotarget

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

(2015) Amal M. El-Naggar et al.   CANCER CELL

AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol

(2015) Shuyang Chen et al.   CELL CYCLE

Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing

(2015) Reinhard Depping et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

(2015) Yoko Goto et al.   Nature Communications

Mitochondrial autophagy: Life and breath of the cell

(2014) Gregg L. Semenza   Autophagy

IFN-  Induces Transcription of Hypoxia-Inducible Factor-1  to Inhibit Proliferation of Human Endothelial Cells

(2014) S. A. Gerber et al.   JOURNAL OF IMMUNOLOGY

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

(2014) L Zeng et al.   ONCOGENE

SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation

(2014) K-S Seo et al.   ONCOGENE

The P-body component USP52/PAN2 is a novel regulator ofHIF1AmRNA stability

(2013) John S. Bett et al.   BIOCHEMICAL JOURNAL

HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia

(2013) Albino Troilo et al.   EMBO REPORTS

Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors

(2012) Chan Yeom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microtubules Regulate Hypoxia-inducible Factor-1α Protein Trafficking and Activity

(2012) Marisa Carbonaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Change of Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of Hypoxia-Inducible Factor 1 and KDM3A

(2012) I. Mimura et al.   MOLECULAR AND CELLULAR BIOLOGY

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression

(2012) F Fallone et al.   ONCOGENE

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

(2012) Gregg L. Semenza   TRENDS IN MOLECULAR MEDICINE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

(2011) Ya-Min Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Can We Overcome Tumor Hypoxia in Radiation Therapy?

(2011) Hiroshi HARADA   JOURNAL OF RADIATION RESEARCH

Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1α

(2010) Dazhong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Casein kinase 1 regulates human hypoxia-inducible factor HIF-1

(2010) A. Kalousi et al.   JOURNAL OF CELL SCIENCE

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α

(2010) M Koslowski et al.   ONCOGENE

Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

(2009) Nobuko Koshikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors

(2008) Hiroshi Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical CRM1-dependent Nuclear Export Signal Mediates Regulation of Hypoxia-inducible Factor-1α by MAPK

(2008) Ilias Mylonis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY