Article
Oncology
Junguo Bu, Wen Yan, Yan Huang, Kehai Lin
Summary: Colorectal cancer (CRC) is a commonly diagnosed cancer, but resistance to chemotherapy reduces its effectiveness. CXCL17 is an inflammatory factor that plays a crucial role in tumorigenesis. However, the function of the CXCL17-GPR35 axis in CRC and drug resistance is not fully understood.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Graeme Milligan
Summary: Despite being poorly characterised, orphan G-protein-coupled receptor 35 (GPR35) has attracted significant interest as a therapeutic target. Differences in pharmacology between human and rodent orthologues of the receptor have restricted preclinical disease models, but recent developments in ligands, transgenic mouse models, and analysis of single-nucleotide polymorphisms (SNPs) have improved understanding and stimulated disease-targeted proof-of-concept studies. This opinion article provides new insights into the biology of GPR35 and discusses its therapeutic potential in various diseases.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Review
Immunology
Berna Kaya, Hassan Melhem, Jan Hendrik Niess
Summary: Diet and gut microbial metabolites play a crucial role in mediating host immune responses and maintaining intestinal health. The metabolite-sensing GPCRs, especially GPR35, are important for signaling that affects host cell function and survival. There is a link between GPR35 and intestinal diseases, with studies showing that it is activated by metabolites such as KYNA, CXCL17, and LPA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sean Patrick Giblin, James Edward Pease
Summary: CXCL17 is a chemotactic cytokine known for its ability to direct leukocyte migration. It is specifically expressed in mucosal tissues and may play specific roles in the tongue, stomach, and lung. Contrary to previous beliefs, recent studies suggest that GPR35 is not its receptor but rather related to the serotonin metabolite 5-hydroxyindoleacetic acid. Additionally, the structure of CXCL17 differs from typical chemokines. This article summarizes the discovery of CXCL17 and discusses the subsequent characterization of this protein.
Review
Biochemistry & Molecular Biology
Vitaly A. Sineshchekov
Summary: The phytochrome (phy) system in plants, consisting of a small number of phytochromes with phyA and phyB as major ones, is responsible for detecting light in the red-far-red region of the solar spectrum. It plays a crucial role in plant development throughout all stages of its life cycle, from seed germination to senescence. PhyA is particularly involved in regulating this cycle, mediating three different types of reactions. It is the sole light receptor in the far-red spectral region, crucial for the survival of plants under a dense plant canopy. The existence of two distinct phyA types, major and light-labile, and minor and light-stable, may explain the diverse modes of phyA action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Hassan Melhem, Berna Kaya, Tanay Kaymak, Philipp Wuggenig, Emilio Flint, Julien Roux, Koen C. Oost, Claudia Cavelti-Weder, Maria L. Balmer, Jean-Claude Walser, Rodrigo A. Morales, Christian U. Riedel, Prisca Liberali, Eduardo J. Villablanca, Jan Hendrik Niess
Summary: This study reveals the critical role of Gpr35 in goblet cell function and its regulation of goblet cell numbers and microbiota balance through maintaining normal pyroptosis levels. It is essential for maintaining intestinal health and the symbiotic relationship between host and microbiota.
MUCOSAL IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Juan Carlos Hernandez-Mondragon, Dexter A. Hernandez-Hernandez, Minerva Crespo-Ramirez, Oscar Prospero-Garcia, Luisa Rocha-Arrieta, Kjell Fuxe, Dasiel O. Borroto-Escuela, Miguel Perez de la Mora
Summary: Enhancing the interaction between dopamine D2 receptors (D2Rs) and oxytocin receptors (OXTRs) in the central amygdala may enhance anxiolytic effects. The coadministration of oxytocin and a D2R agonist improved the anxiolytic effects in rats. In situ proximity ligation assay and BRET2 assay provided evidence for the existence of D2R-OXTR heterocomplexes.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Dong-Soon Im
Summary: GPR35, an orphan receptor, has been found to have 5-HIAA as a high potency ligand, and a transgenic knock-in mouse line with human ortholog of GPR35 has been developed for therapeutic experiments. This article reviews the recent advances and prospective therapeutic directions in GPR35 research.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Chunyan Zhao, Bin Wang, Yifan Liu, Chengcheng Feng, Shihong Xu, Wenqi Wang, Qinghua Liu, Jun Li
Summary: This study confirms the presence of two Kiss/Kissr systems in turbot, and suggests their positive involvement in controlling the reproduction of turbot. These findings provide preliminary information on how the Kiss/Kissr system regulates seasonal reproduction in turbot broodstock.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marco A. Saraiva
Summary: The investigation focused on early Syn aggregates revealed that the micellar-like aggregates formed at around 10 μM and evolved into smaller aggregates (possibly oligomers) at higher protein concentrations. These active species seem to play a role in the protein aggregation mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Ryo Yamane, Kazuki Komatsu, Jun Gouchi, Yoshiya Uwatoko, Shinichi Machida, Takanori Hattori, Hayate Ito, Hiroyuki Kagi
Summary: The study reveals that under high pressure, ice can exhibit different forms of hydrogen-ordered phases, deepening our understanding of the polymorphism of ice and opening up the possibility of completing the phase diagram of ice.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Nina Divorty, Laura Jenkins, Amlan Ganguly, Adrian J. Butcher, Brian D. Hudson, Stefan Schulz, Andrew B. Tobin, Stuart A. Nicklin, Graeme Milligan
Summary: G protein-coupled receptor 35 (GPR35) plays diverse roles in lower gut inflammation and pain. The phosphorylation of specific sites in GPR35a is crucial for its interaction with arrestin-3 and the internalization of the receptor. Phospho-site-specific antisera can effectively detect the activation status of GPR35 and be used in drug discovery and target validation programs.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Oncology
Jiawei Yue, Hui Guo, Peng Xu, Jinhong Ma, Yumin Wu
Summary: Lung cancer is a common and aggressive cancer type. Activation of GPR35 may promote tumor development by enhancing the production of IL-5 and IL-13, leading to the formation of the ILC2-MDSC axis. Additionally, GPR35 is a poor prognostic factor in patients with lung adenocarcinoma. Targeting GPR35 could be a potential strategy for cancer immunotherapy.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Psychology, Social
Adam W. Qureshi, Rebecca L. Monk, Shelby Quinn, Bethan Gannon, Kayleigh Mcnally, Derek Heim
Summary: This study extends our understanding of how crowd emotions spread to individuals by examining the impact of dynamic crowd stimuli on self-reported emotions, attention, and muscle movement. The results suggest that crowd emotions shape affective responses in observers, even without direct attention.
JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY
(2023)
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Gustavo Ramirez-Martinez, Montserrat Sandoval-Vega, Citlaltepetl Salinas-Lara, Carlos Sanchez-Garibay, Cesar Luna-Rivero, Erika Mariana Hernandez-Montiel, Luis Alejandro Fernandez-Lopez, Maria Fernanda Cabrera-Cornejo, Eduardo Misael Choreno-Parra, Alfredo Cruz-Lagunas, Andrea Dominguez, Eduardo Marquez-Garcia, Carlos Cabello-Gutierrez, Francina Valezka Bolanos-Morales, Lourdes Mena-Hernandez, Diego Delgado-Zaldivar, Daniel Rebolledo-Garcia, Parmenides Guadarrama-Ortiz, Nora E. Regino-Zamarripa, Criselda Mendoza-Milla, Ethel A. Garcia-Latorre, Tatiana Sofia Rodiguez-Reyna, Diana Cervantes-Rosete, Carmen M. Hernandez-Cardenas, Shabaana A. Khader, Albert Zlotnik, Joaquin Zuniga
Summary: The study found that serum levels of CXCL17 were increased only in patients with pandemic influenza A(H1N1), and its expression in lung tissue had specific patterns, while no similar observations were made in COVID-19 and TB patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Allergy
James E. Pease, Timothy J. Williams
CLINICAL AND EXPERIMENTAL ALLERGY
(2018)
Editorial Material
Allergy
James E. Pease, Timothy J. Williams
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Immunology
Jennifer Goldblatt, Richard Ashley Lawrenson, Luke Muir, Saloni Dattani, Ashley Hoffland, Tomoko Tsuchiya, Shiro Kanegasaki, Shiranee Sriskandan, James E. Pease
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Franz Puttur, Laura Denney, Lisa G. Gregory, Juho Vuononvirta, Robert Oliver, Lewis J. Entwistle, Simone A. Walker, Mark B. Headley, Ewan J. McGhee, James E. Pease, Matthew F. Krummel, Leo M. Carli, Clare M. Lloyd
SCIENCE IMMUNOLOGY
(2019)
Article
Cell Biology
Caroline A. Anderson, Pallavi Patel, Jonathan M. Viney, Rhian M. Phillips, Roberto Solari, James E. Pease
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Review
Medicine, General & Internal
Leila Motedayen Aval, James E. Pease, Rohini Sharma, David J. Pinato
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Immunology
Bavithra Vijayakumar, Karim Boustani, Patricia P. Ogger, Artemis Papadaki, James Tonkin, Christopher M. Orton, Poonam Ghai, Kornelija Suveizdyte, Richard J. Hewitt, Sujal R. Desai, Anand Devaraj, Robert J. Snelgrove, Philip L. Molyneaux, Justin L. Garner, James E. Peters, Pallav L. Shah, Clare M. Lloyd, James A. Harker
Summary: Patients with persistent lung disease after COVID-19 discharge exhibit abnormal immune-proteomic profiles in the airways, characterized by elevated levels of proteins associated with cell death, tissue repair, and epithelial injury. The severity of airway dysfunction correlates with increased cytotoxic lymphocyte counts, while more extensive lung abnormalities are associated with elevated B cell numbers and altered monocyte subsets. Long-term follow-up indicates that these abnormalities resolve over time.
Review
Immunology
Sophie McKenna, Kristin Krohn Huse, Sean Giblin, Max Pearson, Mohammed Said Majid Al Shibar, Shiranee Sriskandan, Stephen Matthews, James Edward Pease
Summary: Bacteria, such as streptococci, have evolved sophisticated strategies to evade the host immune system, including the use of proteases like SpyCEP and C5a peptidase to neutralize key immune response molecules such as CXCL8 and C5a. Targeting these proteases through vaccination or small-molecule antagonists may provide protection against streptococcal infections.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Multidisciplinary Sciences
Sophie McKenna, Sean Patrick Giblin, Rosemarie Anne Bunn, Yingqi Xu, Stephen John Matthews, James Edward Pease
Summary: Chemokines play significant roles in the immune system and human disease, making the production of folded and bioactive recombinant chemokines crucial for their study. This study presents a novel method for producing soluble chemokines in large quantities without the need for refolding, streamlining the generation of recombinant chemokines.
Article
Medicine, General & Internal
Michael Popoola, Marston Hillier
Summary: Purple urine bag syndrome is a curious condition characterized by purple discoloration of a urinary catheter bag caused by a urinary tract infection. Predisposing factors include old age, long-term catheterization, chronic constipation, and limited mobility. Lack of knowledge about this uncommon syndrome among clinicians may have implications on patient outcomes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Respiratory System
Karim Boustani, Poonam Ghai, Rachele Invernizzi, Richard J. Hewitt, Toby M. Maher, Quan-Zhen Li, Philip L. Molyneaux, James A. Harker
Summary: This study extensively characterized the airway and peripheral autoantibody profiles in patients with fibrotic interstitial lung disease (fILD) and identified a subset of patients with a local autoimmune signature in their airways. The presence of airway autoantibodies did not affect survival probability or lung function changes in the overall cohort. However, further investigation is needed to understand the mechanisms by which these autoantibodies contribute to the disease.
Article
Pharmacology & Pharmacy
J. E. Pease
Summary: Inflammation is a key component in various clinically important disorders, with neutrophil recruitment playing a crucial role. C5a is a potent chemoattractant for neutrophils, while Avacopan, a small molecule antagonist of C5aR1, inhibits neutrophil recruitment and shows potential efficacy in treating ANCA-induced vasculitis.
DRUGS OF THE FUTURE
(2021)
Article
Biochemistry & Molecular Biology
Sophie McKenna, Enrico Malito, Sarah L. Rouse, Francesca Abate, Giuliano Bensi, Emiliano Chiarot, Francesca Micoli, Francesca Mancini, Danilo Gomes Moriel, Guido Grandi, Danuta Mossakowska, Max Pearson, Yingqi Xu, James Pease, Shiranee Sriskandan, Immaculada Margarit, Matthew J. Bottomley, Stephen Matthews
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2020)
Review
Immunology
Sergio M. Pontejo, Philip M. Murphy, James E. Pease
JOURNAL OF INNATE IMMUNITY
(2018)