Article
Oncology
Yihe Yan, Leting Zheng, Qiang Du, Hamza Yazdani, Kun Dong, Yarong Guo, David A. Geller
Summary: IRF-1 regulates anti-tumor immunity in HCC by modulating CXCL10 and CXCR3, inhibiting proliferation and promoting apoptosis. It overcomes proliferation partly through activating the CXCL10/CXCR3 autocrine axis.
Article
Oncology
Tomonori Higuchi, Yumiko Hashida, Kazuhiko Matsuo, Kosuke Kitahata, Takako Ujihara, Ichiro Murakami, Takashi Nakayama, Masanori Daibata
Summary: Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma associated with chronic inflammation (DLBCL-CI) develops in the setting of long-standing inflammation. This type of lymphoma may have specific expression profiles of chemokines involved in the pathogenesis of DLBCL-CI. EBV-positive pyothorax-associated lymphoma (PAL) is a prototype of DLBCL-CI and represents a valuable model for the study of this disease category.
Article
Microbiology
Xin Yu, Ying Chen, Lele Cui, Kaming Yang, Xumeng Wang, Linyuan Lei, Yanping Zhang, Xinyi Kong, Wanwen Lao, Zhenlin Li, Yang Liu, Yuetong Li, Changlong Bi, Chao Wu, Aixia Zhai
Summary: This study found that CXCL8, CXCL9, CXCL10, and CXCL11 can be used as serum biomarkers to forecast liver injury caused by HBV infection, using a combination of bioinformatics, cell experiments, and clinical correlation analysis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jan-Hendrik Riedel, Lennart Robben, Hans-Joachim Paust, Yu Zhao, Nariaki Asada, Ning Song, Anett Peters, Anna Kaffke, Alina Borchers, Gisa Tiegs, Larissa Seifert, Nicola M. Tomas, Elion Hoxha, Ulrich O. Wenzel, Tobias B. Huber, Thorsten Wiech, Jan-Eric Turner, Christian F. Krebs, Ulf Panzer
Summary: Glucocorticoids, a cornerstone of therapy for autoimmune and chronic inflammatory diseases, exert their therapeutic effects by reducing the number of proinflammatory T cells in the kidney. This study found that high-dose steroid treatment decreases the recruitment of CXCR3(+)CD4(+) T cells to the inflamed kidneys by acting directly on renal tissue cells, leading to an amelioration of the disease course. The study identified the CXCL9/CXCL10-CXCR3 axis as a previously unrecognized cellular and molecular target of glucocorticoids.
Article
Microbiology
Farzaneh Hassanshahi, Mojgan Noroozi Karimabad, Elahe Miranzadeh, Gholamhossein Hassanshahi, Seyedeh Atekeh Torabizadeh, Ali Jebali
Summary: The study investigated the association between Brucella infection and the chemokines CXCL9, 10, and 11. The results showed that the serum levels of these chemokines were significantly increased in patients with acute brucellosis, suggesting their potential as markers for the disease.
CURRENT MICROBIOLOGY
(2023)
Article
Oncology
Jack Y. Lee, Bianca Nguyen, Anandaroop Mukhopadhyay, Mia Han, Jun Zhang, Ravindra Gujar, Jon Salazar, Reneta Hermiz, Lauren Svenson, Erica Browning, H. Kim Lyerly, David A. Canton, Daniel Fisher, Adil Daud, Alain Algazi, Joseph Skitzki, Christopher G. Twitty
Summary: This study demonstrates that localized IL-12 and CXCL9 treatment can reshape the tumor microenvironment, promote immune cell activation, and induce anti-tumor responses. Additionally, this combination treatment shows synergy with anti-PD-1 therapies.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Immunology
Xuan Wang, Mara Lennard Richard, Tomika S. Caldwell, Kamala Sundararaj, Shuzo Sato, Tamara K. Nowling, Xian K. Zhang
Summary: The transcription factor Fli-1 is involved in the pathogenesis of lupus disease by regulating the expression of CXCL10 and CXCR3, which play important roles in renal inflammation and damage. Targeting Fli-1 or the CXCL10-CXCR3 axis may provide new approaches for lupus treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Johanna Huoman, Sadia Haider, Angela Simpson, Clare S. Murray, Adnan Custovic, Maria C. Jenmalm
Summary: Studies found that in children with asthma and/or allergic sensitization, elevated CCL18 levels at ages 1 and/or 8 were associated with a higher risk of developing asthma from early school age to adolescence. Similarly, chemokines CXCL10 and CXCL11 were also linked to the development of both allergic sensitization and asthma, with differential temporal effects present.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Developmental Biology
Yue Zhang, YingJiao Chen, Linyu Zhang, YiLun Wu, Ying Feng, Fang Ma
Summary: Trophoblast cells are crucial for embryo recognition, localization, and placental development during embryo implantation. High-throughput sequencing identified 438 differentially expressed mRNAs and 41 lncRNAs associated with embryo cessation. CLRN1-AS1 was found to significantly affect the adhesion function of trophoblast cells. It modulates the adhesion ability of trophoblast cells to the extracellular matrix by influencing the chemokines CXCL10/CXCL11.
Article
Virology
Victoria Callahan, Seth Hawks, Matthew A. Crawford, Caitlin W. Lehman, Holly A. Morrison, Hannah M. Ivester, Ivan Akhrymuk, Niloufar Boghdeh, Rafaela Flor, Carla Finkielstein, Irving Coy Allen, James Weger-Lucarelli, Nisha Duggal, Molly A. Hughes, Kylene Kehn-Hall
Summary: The study shows that SARS-CoV-2 infection induces an inflammatory state in human lung epithelial cells with elevated levels of pro-inflammatory chemokines and cytokines. Inhibition of the AKT pathway may reduce the induction of these chemokines, potentially providing specific targets for mitigating SARS-CoV-2 pathogenesis associated with hyperinflammation.
Article
Immunology
Yang Li, Shukun Han, Baokang Wu, Chongli Zhong, Yu Shi, Chao Lv, Lei Fu, Yizhou Zhang, Qi Lang, Zhiyun Liang, Yang Yu, Yu Tian
Summary: CXCL11 expression is higher in tumor tissue and has associations with prognosis, immune cell infiltration, tumor mutation burden, and microsatellite instability. Further investigation into CXCL11 may improve cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elisa F. Brandt, Maike Baues, Theresa H. Wirtz, Jan-Niklas May, Petra Fischer, Anika Beckers, Bjorn-Carsten Schure, Hacer Sahin, Christian Trautwein, Twan Lammers, Marie-Luise Berres
Summary: This study analyzed the function of chemokine CXCL10 in fibrosis-associated hepatocarcinogenesis and found that CXCL10 has a significant impact on shaping the tumor microenvironment. CXCL10 deficiency attenuated hepatocarcinogenesis and altered tumor-associated immune response and chemokine networks. The results demonstrate that interfering with CXCL10 could be a novel asset for improving therapeutic strategies in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wenlu Xiao, Hao Huang, Panpan Zheng, Yingting Liu, Yaping Chen, Junjun Chen, Xiao Zheng, Lujun Chen, Jingting Jiang
Summary: Thermal ablation enhances tumor antigen presentation to the immune system and activates tumor-specific T cells, while the interaction between macrophages and CD8(+)T cells through the CXCL10/CXCR3 pathway contributes to the therapeutic effect. Combination therapy of thermal ablation and PD-1 blockade shows a synergistic anti-tumor effect, and the CXCL10/CXCR3 axis plays a vital role in this combination treatment.
Article
Biology
Veethika Pandey, Alicia Fleming-Martinez, Ligia Bastea, Heike R. Doeppler, Jillian Eisenhauer, Tam Le, Brandy Edenfield, Peter Storz
Summary: This study highlights the importance of CXCL10/CXCR3 signaling in the early phase of murine pancreatic cancer, demonstrating its role in mediating chemotaxis, proliferation, and maintenance of inflammatory identity in macrophages within the pancreas. Inhibition of CXCL10/CXCR3 signaling shifts macrophage populations to a tumor-promoting phenotype, increasing fibrosis and lesion progression.
Review
Oncology
Aissata Aimee Goita, Dominique Guenot
Summary: This review discusses the role of the CXCL12 axis and its receptors CXCR4 and CXCR7 in colorectal cancer, highlighting their potential as therapeutic targets.
Review
Oncology
Damla Isci, Giulia D'Uonnolo, May Wantz, Bernard Rogister, Arnaud Lombard, Andy Chevigne, Martyna Szpakowska, Virginie Neirinckx
Summary: This study aims to decipher the functions of several chemokine receptors in gliomas and highlight the clinical relevance of chemokine receptors in targeted therapeutic approaches for glioma patients. It investigates the expression profile and complex roles of chemokine receptors in glioma patients based on publicly available patient-derived transcriptomic data and emphasizes the importance of patient-derived material for the development of chemokine receptor-targeting therapies.
Editorial Material
Oncology
Yosra Messai, Muhammad Zaeem Noman, Meriem Hasmim, Bassam Janji, Andres Tittarelli, Marie Boutet, Veronique Baud, Elodie Viry, Katy Billot, Arash Nanbakhsh, Thouraya Ben Safta, Catherine Richon, Sophie Ferlicot, Emmanuel Donnadieu, Sophie Couve, Betty Gardie, Florence Orlanducci, Laurence Albiges, Jerome Thiery, Daniel Olive, Bernard Escudier, Salem Chouaib
Article
Biochemistry & Molecular Biology
Malina Xiao, Caroline Duhem, Anwar Chammout, Guy Berchem, Bassam Janji
Summary: The expression of PD-L1 has been used as a biomarker for cancer patients, but its dynamic and heterogeneous expression raises questions about its reliability. Understanding the molecular basis of PD-L1 expression is crucial for determining its value as a reliable biomarker in clinical settings.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Nicole Kiweler, Catherine Delbrouck, Vitaly Pozdeev, Laura Neises, Leticia Soriano-Baguet, Kim Eiden, Feng Xian, Mohaned Benzarti, Lara Haase, Eric Koncina, Maryse Schmoetten, Christian Jaeger, Muhammad Zaeem Noman, Alexei Vazquez, Bassam Janji, Gunnar Dittmar, Dirk Brenner, Elisabeth Letellier, Johannes Meiser
Summary: The study reveals that antifolate treatment results in an uncoupled mitochondrial one-carbon metabolism, which supports cancer cell migration. Inhibition of serine de novo synthesis reduces cancer cell migration, and specifically inhibiting mitochondrial serine catabolism can strongly inhibit pulmonary metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Giulia D'Uonnolo, Nathan Reynders, Max Meyrath, Dayana Abboud, Tomasz Uchanski, Toon Laeremans, Brian F. Volkman, Bassam Janji, Julien Hanson, Martyna Szpakowska, Andy Chevigne
Summary: This study provides an in-depth comparative analysis of the CXCR3-A and CXCR3-B isoforms, revealing significant differences in receptor features and signaling. It highlights the beta-arrestin bias and atypical nature of CXCR3-B.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Ali Kishk, Maria Pires Pacheco, Tony Heurtaux, Lasse Sinkkonen, Jun Pang, Sabrina Fritah, Simone P. Niclou, Thomas Sauter
Summary: This review highlights the evolution of genome-scale models for neurodegenerative diseases and glioma, discussing the advantages and drawbacks of each approach and proposing improvements.
Article
Immunology
Meriem Hasmim, Malina Xiao, Kris Van Moer, Akinchan Kumar, Alexandra Oniga, Michel Mittelbronn, Caroline Duhem, Anwar Chammout, Guy Berchem, Jean Paul Thiery, Marianna Volpert, Brett Hollier, Muhammad Zaeem Noman, Bassam Janji
Summary: This study reveals a new mechanism of CD73 regulation in triple-negative breast cancer, suggesting that CD73 blocking could be an attractive therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Delphine Sauvage, Manon Bosseler, Elodie Viry, Georgia Kanli, Anais Oudin, Guy Berchem, Olivier Keunen, Bassam Janji
Summary: This study evaluates the therapeutic benefit of combining anti-PD-1 with JQ1 in a neuroblastoma mouse model and provides pre-clinical proof of concept for a new combination immunotherapy approach that may be effective in treating high-risk childhood neuroblastoma.
Article
Oncology
David Capper, Guido Reifenberger, Pim J. French, Leonille Schweizer, Michael Weller, Mehdi Touat, Simone P. Niclou, Philipp Euskirchen, Christine Haberler, Monika E. Hegi, Sebastian Brandner, Emilie Le Rhun, Roberta Ruda, Marc Sanson, Ghazaleh Tabatabai, Felix Sahm, Patrick Y. Wen, Pieter Wesseling, Matthias Preusser, Martin J. van den Bent
Summary: The mainstay of treatment for adult patients with gliomas, glioneuronal and neuronal tumors consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic cancers, targeted treatments are a part of the standard of care, however, the predictive significance of most of these targets in central nervous system (CNS) tumors remains less well-studied.
Article
Multidisciplinary Sciences
Justine S. Paradis, Xiang Feng, Brigitte Murat, Robert E. Jefferson, Badr Sokrat, Martyna Szpakowska, Mireille Hogue, Nick D. Bergkamp, Franziska M. Heydenreich, Martine J. Smit, Andy Chevigne, Michel Bouvier, Patrick Barth
Summary: This article presents a computational approach for predicting receptor self-associations and designing receptor oligomers with various quaternary structures and signaling properties. Using this approach, the chemokine receptor CXCR4 dimers were successfully designed to have different conformations and abilities to activate distinct intracellular signaling proteins. The study also revealed the existence of a bias switch at the dimer interface of several G protein-coupled receptors, including CXCR4, mu-Opioid, and type-2 Vasopressin receptors, that selectively control the activation of G proteins vs beta-arrestin-mediated pathways.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Muhammad Zaeem Noman, Irene Adelaide Bocci, Manale Karam, Kris Van Moer, Manon Bosseler, Akinchan Kumar, Guy Berchem, Christian Auclair, Bassam Janji
Summary: The study reveals that Harmine, by increasing the expression of MHC-I, enhances the immune features of melanoma cells and inhibits tumor growth. Combination therapy with ACB1801 and anti-PD1 shows improved therapeutic benefits. Clinical data further supports the use of ACB1801 in combination with anti-PD1/PD-L1 therapy to improve survival in cancer patients with a defect in MHC-I expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Oncology
Meriem Hasmim, Guy Berchem, Bassam Janji
Summary: This article discusses the upregulation of CD73 by SNAI1 in triple negative breast cancer cells, which drives epithelial-to-mesenchymal transition (EMT). The authors also explore the relevance of combining CD73-based therapy with EMT inhibitors to improve treatment outcomes.
Editorial Material
Oncology
Simone P. Niclou, Anna Golebiewska
Article
Neurosciences
Nuria Sanchez-Fernandez, Laura Gomez-Acero, Laura I. Sarasola, Josep Argerich, Andy Chevigne, Kenneth A. Jacobson, Francisco Ciruela, Victor Fernandez-Duenas, Ester Aso
Summary: This study investigated the effect of cannabidiol (CBD) on the function of adenosine A2A receptors (A2AR). The results showed that CBD can decrease the coupling between A2AR and Gas protein, leading to a reduction in cAMP generation.
ACTA NEUROPSYCHIATRICA
(2023)
Review
Cell Biology
Alice Benoit, Guillaume Vogin, Caroline Duhem, Guy Berchem, Bassam Janji
Summary: Immunotherapy with immune checkpoint inhibitors (ICI) has shown significant clinical benefits for cancer patients. However, a majority of patients do not respond well to ICI due to lack of immune cell infiltration in the tumor microenvironment. This review discusses the factors contributing to cold tumors and strategies to transform them into inflamed hot tumors, with a focus on targeting hypoxia for metabolic reprogramming and improving ICI efficacy.
