Article
Gastroenterology & Hepatology
Megan T. Hoffman, Samantha B. Kemp, Daniel J. Salas-Escabillas, Yaqing Zhang, Nina G. Steele, Stephanie The, Daniel Long, Simone Benitz, Wei Yan, Robert F. Margolskee, Filip Bednar, Marina Pasca di Magliano, Hui-Ju Wen, Howard C. Crawford
Summary: This study demonstrates that inhibiting GNAT3 can increase the release of tumor-promoting cytokines, alter the MDSC population, and promote the progression of metastatic PDA.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Steven H. Sun, Brooke Benner, Himanshu Savardekar, Gabriella Lapurga, Logan Good, David Abood, Erin Nagle, Megan Duggan, Andrew Stiff, Mallory J. DiVincenzo, Lorena P. Suarez-Kelly, Amanda Campbell, Lianbo Yu, Robert Wesolowski, Harrison Howard, Hiral Shah, Kari Kendra, William E. Carson
Summary: In melanoma patients receiving immune checkpoint inhibitors, MDSC levels increased significantly in some responders, while PMN-MDSC decreased and CD14+CD15+ MDSC increased significantly in PD patients. Changes in MDSC levels may have prognostic value in immune checkpoint inhibitor therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zibing Wang, Yuqing Liu, Ling Peng, Brian Till, Yuwei Liao, Shumin Yuan, Xiang Yan, Lin Chen, Qiang Fu, Zhihai Qin
Summary: The role of B cells in the anti-tumor immune response is controversial. An increase in the number of B cells in the peripheral blood of some tumor patients has been associated with poor immunotherapy efficacy. This study suggests that CD11b(+) myeloid cells promote B cell proliferation, activation, and survival, and targeting B cells may increase the efficacy of immunotherapy in tumor-bearing hosts.
Article
Gastroenterology & Hepatology
Huarong Chen, Yasi Pan, Qiming Zhou, Cong Liang, Chi-Chun Wong, Yunfei Zhou, Dan Huang, Weixin Liu, Jianning Zhai, Hongyan Gou, Hao Su, Xiaoting Zhang, Hongzhi Xu, Yifei Wang, Wei Kang, William Ka Kei Wu, Jun Yu
Summary: This study identifies METTL3 as a potential therapeutic target for CRC immunotherapy. Silencing or inhibiting METTL3 reduces MDSC accumulation, sustains activation and proliferation of CD4(+) and CD8(+) T cells, and ultimately suppresses CRC development. Inhibition of METTL3 plus anti-PD1 treatment shows promising antitumor efficacy against CRC.
Article
Immunology
Tianju Liu, Francina Gonzalez De Los Santos, Andrew E. Rinke, Chuling Fang, Kevin R. Flaherty, Sem H. Phan
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease without effective therapy. This study investigated the role of myeloid-derived suppressor cells (MDSCs) expressing B7H3 in IPF. The expansion of MDSCs correlated with disease severity in IPF patients. B7H3-mediated MDSCs activated lung fibroblasts and myofibroblast differentiation, and also suppressed T-cell proliferation. Inhibition of MDSC recruitment with anti-B7H3 antibodies reduced inflammation and fibrosis in a mouse model of pulmonary fibrosis. These findings suggest that MDSCs and B7H3 may play a significant role in the progression of IPF and could be potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jinyu Zhang, Bal Krishna Chand Thakuri, Juan Zhao, Lam N. Nguyen, Lam N. T. Nguyen, Sushant Khanal, Dechao Cao, Xindi Dang, Madison Schank, Zeyuan Lu, Xiao Y. Wu, Zheng D. Morrison, Mohamed El Gazzar, Yong Jiang, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao
Summary: The RUNXOR-RUNX1 axis promotes the differentiation and suppressive functions of MDSCs by regulating multiple immunosuppressive signaling molecules, representing a potential target for immunotherapy in conjunction with antiviral therapy in people living with HIV (PLHIV).
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Paola Grazioli, Andrea Orlando, Nike Giordano, Claudia Noce, Giovanna Peruzzi, Behnaz Abdollahzadeh, Isabella Screpanti, Antonio Francesco Campese
Summary: This study reveals that dysregulation of the Notch signaling pathway in T cells promotes the production of MDSCs in a T-ALL mouse model. IL-6 is found to mediate the induction of MDSCs in both mouse and human models.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shinan Li, Fujie Li, Xinying Liu, Xiaoxu Zhu, Wanlin Gao, Xiaokun Shen
Summary: In this study, Pam3CSK4 injection was found to attenuate tumor growth, decrease MDSCs, and restore T cell function; Pam3CSK4 promoted MDSC polarization by targeting Runx1, while a Runx1 inhibitor reversed this effect; TLR2 and Runx1 play critical roles in regulating the differentiation and function of MDSCs, potentially through the ferroptosis pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Huimin Tao, Mingyu Liu, Yuan Wang, Shufeng Luo, Yongquan Xu, Bin Ye, Limin Zheng, Kun Meng, Lian Li
Summary: Studies show that icaritin can suppress tumor progression and increase the survival of mice with HCC by reducing MDSC accumulation and activation, while enhancing cytotoxic T cell activity. Icaritin achieves this by downregulating splenic EMH, leading to decreased MDSC generation and activation, thereby dampening tumoral immunosuppression and promoting anti-tumor immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Germana Grassi, Stefania Notari, Simona Gili, Veronica Bordoni, Rita Casetti, Eleonora Cimini, Eleonora Tartaglia, Davide Mariotti, Chiara Agrati, Alessandra Sacchi
Summary: SARS-CoV-2 is the causative agent of COVID-19, which can lead to severe respiratory distress syndrome. The immune response in COVID-19 patients is impaired, and there is a massive expansion of MDSCs. The early expansion of MDSCs can predict the fatal outcome of the infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Padma Kadiyala, Ahmed M. Elhossiny, Eileen S. Carpenter
Summary: This review focuses on the application of single-cell RNA sequencing to define the myeloid compartment in human PDAC and elucidate the crosstalk between myeloid cells and the other components of the tumor immune microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Geetu Rose Varghese, Dipyaman Patra, Vishnu Sunil Jaikumar, Arathi Rajan, Neetha R. Latha, Priya Srinivas
Summary: This study demonstrates that ss hCG suppresses the host antitumor immune response and contributes to tumour progression in BRCA1 deficient TNBC. These findings will aid in the development of new immunotherapeutic approaches for treating BRCA1 defective TNBC by regulating ss hCG.
Review
Oncology
Amit Grover, Emilio Sanseviero, Elina Timosenko, Dmitry Gabrilovich
Summary: MDSCs are important regulators of immune responses in cancer, and their association with negative clinical outcomes makes them attractive therapeutic targets. However, the complex nature of MDSC biology presents a substantial challenge for therapeutic targeting. This review discusses the challenges and potential solutions in targeting MDSCs for therapeutic intervention.
Article
Biochemistry & Molecular Biology
Viva J. Rase, Reid Hayward, James M. Haughian, Nicholas A. Pullen
Summary: Immunotherapies relying on type 1 immunity have shown limited effectiveness in solid breast tumors. This study investigated the role of type 3 immunity in breast cancer and found that IL-6 depletion combined with immunotherapy could improve outcomes by expanding T(h)17 cell populations and reducing T(h)22 cells and MDSC. This suggests that targeting IL-6 could be a potential strategy to overcome immunotherapy resistance in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jia-Nan Cheng, Yi-Xiao Yuan, Bo Zhu, Qingzhu Jia
Summary: MDSCs play a crucial role in regulating immune responses, promoting tumor progression, and predicting therapeutic outcomes. Targeting MDSCs could potentially improve treatment efficacy in cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Huifang Shi, Juechao Zhang, Xiaoqing Han, Huihan Li, Mingshu Xie, Yingying Sun, Wenguang Liu, Xueqing Ba, Xianlu Zeng
INTERNATIONAL JOURNAL OF CANCER
(2017)
Article
Cell Biology
Peter German, David Saenz, Peter Szaniszlo, Leopoldo Aguilera-Aguirre, Lang Pan, Muralidhar L. Hegde, Attila Bacsi, Gyorgy Hajas, Zsolt Radak, Xueqing Ba, Sankar Mitra, John Papaconstantinou, Istvan Boldogh
MECHANISMS OF AGEING AND DEVELOPMENT
(2017)
Article
Multidisciplinary Sciences
Yueshuang Ke, Yanlong Han, Xiaolan Guo, Jitao Wen, Ke Wang, Xue Jiang, Xue Tian, Xueqing Ba, Istvan Boldogh, Xianlu Zeng
NATURE COMMUNICATIONS
(2017)
Article
Biochemical Research Methods
Yueshuang Ke, Ke Wang, Hui Xu, Chenxin Wang, Jing Zhang, Xianlu Zeng, Ruoxi Wang, Istvan Boldogh, Xueqing Ba
MOLECULAR AND CELLULAR PROBES
(2018)
Article
Cell Biology
Ruoxi Wang, Chunshuang Li, Ping Qiao, Yaoyao Xue, Xu Zheng, Hongyu Chen, Xianlu Zeng, Wenguang Liu, Istvan Boldogh, Xueqing Ba
CELL DEATH & DISEASE
(2018)
Article
Cell Biology
Liangping Su, Hongyuan Li, Cheng Huang, Tingting Zhao, Yongjun Zhang, Xueqing Ba, Zhongwei Li, Yu Zhang, Baiqu Huang, Jun Lu, Yanmei Zhao, Xiaoxue Li
Article
Biochemistry & Molecular Biology
Wenjing Hao, Tianyang Qi, Lang Pan, Ruoxi Wang, Bing Zhu, Leopoldo Aguilera-Aguirre, Zsolt Radak, Tapas K. Hazra, Spiros A. Vlahopoulos, Attila Bacsi, Allan R. Brasier, Xueqing Ba, Istvan Boldogh
Review
Biochemistry & Molecular Biology
Xueqing Ba, Istvan Boldogh
Review
Biochemistry & Molecular Biology
Ruoxi Wang, Wenjing Hao, Lang Pan, Istvan Boldogh, Xueqing Ba
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
Article
Multidisciplinary Sciences
Torkild Visnes, Armando Cazares-Korner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisee Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga-Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J. Homan, Bishoy M. F. Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina von Nicolai, Carlos Benitez-Buelga, Tobias Koolmeister, Dag Ivanic, Petar Iliev, Martin Scobie, Hans E. Krokan, Pawel Baranczewski, Per Artursson, Mikael Altun, Annika Jenmalm Jensen, Christina Kalderen, Xueqing Ba, Roman A. Zubarev, Pal Stenmark, Istvan Boldogh, Thomas Helleday
Review
Biochemistry & Molecular Biology
Yueshuang Ke, Jing Zhang, Xueping Lv, Xianlu Zeng, Xueqing Ba
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Yueshuang Ke, Xueping Lv, Xingyue Fu, Jing Zhang, Ameer Ali Bohio, Xianlu Zeng, Wenjing Hao, Ruoxi Wang, Istvan Boldogh, Xueqing Ba
Summary: PARylation is an important post-translational modification that increases the formation of HuR oligomer/multimer, which in turn promotes the disassociation of miRISC and stabilizes pro-inflammatory gene mRNAs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lang Pan, Wenjing Hao, Yaoyao Xue, Ke Wang, Xu Zheng, Jixian Luo, Xueqing Ba, Yang Xiang, Xiaoqun Qin, Jesper Bergwik, Lloyd Tanner, Arne Egesten, Allan R. Brasier, Istvan Boldogh
Summary: This study reveals that reactive oxygen species (ROS) can induce epithelial cell-state transition and ECM deposition during airway injury. They found that oxidative DNA damage, specifically the formation of 8-oxoG lesions, functions as a pioneer factor in transcriptional reprogramming of airway epithelial cells. These findings provide important insights into the role of oxidative DNA damage in mediating profibrotic processes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Physiology
Leopoldo Aguilera-Aguirre, Wenging Hao, Lang Pan, Xiaoxue Li, Alfredo Saavedra-Molina, Attila Bacsi, Zsolt Radak, Sanjiv Sur, Allan R. Brasier, Xueqing Ba, Istvan Boldogh
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2017)