Article
Biochemistry & Molecular Biology
Rachele Di Donato, Raffaella Bonecchi, Francesca Albano
Summary: Chemokines have local functions in controlling leukocyte extravasation and also play additional roles in regulating hematopoiesis and leukocyte differentiation at a systemic level. Atypical chemokine receptors (ACKRs) are regulators of the chemokine system and have a selective role in neutrophil production and differentiation. This review provides an overview of the role of chemokines and chemokine receptors in neutrophil biology with a focus on the regulation exerted by ACKRs.
Article
Oncology
Shweta Arora, Salman Khan, Almaz Zaki, Gulnaz Tabassum, Mohd Mohsin, Humaira Naaz Bhutto, Tanveer Ahmad, Tasneem Fatma, Mansoor Ali Syed
Summary: This article discusses the role of chemokines and non-coding RNAs in modulating tumor progression, as well as their communication in the tumor microenvironment and potential as novel therapeutic targets.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Immunology
Dominic D. Skinner, Amber R. Syage, Gema M. Olivarria, Colleen Stone, Bailey Hoglin, Thomas E. Lane
Summary: By characterizing the molecular and cellular changes in transgenic mice, this study reveals the changes in the profile of neutrophils associated with increased white matter damage in mice persistently infected with a neurotropic coronavirus.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Joanna Ewa Sowa, Krzysztof Tokarski
Summary: This review summarizes the mechanisms underlying chemokine regulation of neuron-glia crosstalk at molecular, cellular, network, and behavioral levels, in order to propose new treatment strategies for promoting brain repair and reducing neurological impairment.
PHARMACOLOGICAL REPORTS
(2021)
Article
Multidisciplinary Sciences
Cameron R. Bastow, Mark D. Bunting, Ervin E. Kara, Duncan R. McKenzie, Adriana Caon, Sapna Devi, Lynn Tolley, Scott N. Mueller, Ian H. Frazer, Natasha Harvey, Mark R. Condina, Clifford Young, Peter Hoffmann, Shaun R. McColl, Iain Comerford
Summary: This study reveals the mechanism by which ACKR4 controls DC migration in barrier tissues, identifying the existence of two forms of CCL21 in steady-state conditions and their regulation by ACKR4. It enhances understanding of functional chemokine gradient formation by showing how ACKR4 affects CCL21 gradients in barrier tissues and downstream lymph nodes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Sofia R. Gardeta, Eva M. Garcia-Cuesta, Gianluca D'Agostino, Blanca Soler Palacios, Adriana Quijada-Freire, Pilar Lucas, Jorge Bernardino de la Serna, Carolina Gonzalez-Riano, Coral Barbas, Jose Miguel Rodriguez-Frade, Mario Mellado
Summary: The local lipid environment plays an important role in regulating CXCR4 organization and function, and modulating chemokine-triggered directed cell migration. Treatment of T cells with bacterial sphingomyelinase alters the lipid composition of the cell membrane, affecting membrane fluidity and CXCR4 nanoclustering and dynamics.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Andrea Bonnin Marquez, Emiel P. C. van der Vorst, Sanne L. Maas
Summary: Atherosclerosis is a major cause of cardiovascular diseases, and chemokines and their receptors play a crucial role in its pathophysiological development. Targeting these factors through various methods shows promise in ameliorating atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Teizo Yoshimura, Chunning Li, Yuze Wang, Akihiro Matsukawa
Summary: Breast cancer is a common cancer worldwide, and metastasis is the main cause of cancer-related death. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was identified as a chemotactic factor for monocytes, and its role in cancer development and progression was investigated. Studies showed positive correlations between MCP-1 production in tumors and TAM infiltration, as well as cancer progression. MCP-1 was found to promote breast cancer metastasis to the lung and brain, but not bone. The mechanisms of MCP-1 production in the breast cancer microenvironment were also reported.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Oncology
Mudassier Ahmad, Anupam Dhasmana, Prateek Suresh Harne, Asif Zamir, Bilal Bin Hafeez
Summary: Tumor heterogeneity is a crucial factor in the resistance to chemotherapy and limited efficacy in hepatocellular carcinoma (HCC). Chemokines, a sub-family of cytokines, play a key role in HCC heterogeneity by affecting cell survival, growth, migration, and angiogenesis. Understanding the impact of chemokines on genetic, epigenetic, metabolic, immune cell composition, and tumor microenvironment levels can contribute to the development of personalized medicine strategies for HCC.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Alessio Ardizzone, Rossella Basilotta, Alessia Filippone, Lelio Crupi, Marika Lanza, Sofia Paola Lombardo, Cristina Colarossi, Dorotea Sciacca, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo
Summary: Primary brain tumors are highly heterogeneous and invasive, leading to high mortality rates worldwide. Current therapies have improved survival rates, but new therapeutic strategies are needed. Immunotherapy approaches, targeting the immunosuppressive microenvironment, have shown promise in CNS tumors. Chemokines, a group of proteins that regulate immune cell recruitment and tumor growth, are examined as potential targets for immunotherapy in primary brain tumors.
Review
Oncology
Jiakang Jin, Jinti Lin, Ankai Xu, Jianan Lou, Chao Qian, Xiumao Li, Yitian Wang, Wei Yu, Huimin Tao
Summary: CCL2 plays a crucial role in tumor microenvironment by recruiting macrophages and stromal cells, impacting tumor progression both negatively and positively by influencing the immune response.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hunter G. Lindsay, Colby J. Hendrix, Josue D. Gonzalez Murcia, Christopher Haynie, K. Scott Weber
Summary: Neuroinflammation plays a significant role in neurodegenerative disorders, and the role of atypical chemokine receptors (ACKRs) in these conditions has been identified. ACKRs modulate inflammatory responses by regulating chemokine abundance, location, and availability. The ability of ACKRs to alter chemokine levels makes them an appealing therapeutic target for neurodegenerative conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Tao Fan, Yu Liu, Hengchang Liu, Liyu Wang, He Tian, Yujia Zheng, Bo Zheng, Liyan Xue, Fengwei Tan, Qi Xue, Shungeng Gao, Chunxiang Li, Jie He
Summary: This study characterized the expression profiles of chemokine and chemokine receptor family members in LUAD, and constructed a prognosis signature based on five chemokines and chemokine receptors. The signature was verified to be an independent prognostic factor for LUAD and provided a robust prognostic biomarker, showing potential for predicting immunotherapy response.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Oncology
Raffaella Bonecchi, Alberto Mantovani, Sebastien Jaillon
Summary: Neutrophils, the main leukocyte subset in human blood, have a crucial role in defending against infections and also play a significant role in the tumor stroma. Tumor-associated neutrophils can have both protumor and antitumor activities, and chemokines and chemokine receptors are considered targets to improve their antitumoral function in cancer immunotherapy. Targeting chemokines or chemokine receptors can modulate neutrophil activity and enhance their antitumor properties.
Review
Biochemistry & Molecular Biology
Katarzyna Pawlik, Joanna Mika
Summary: Neuropathic pain is a chronic condition that significantly reduces patients' quality of life. Currently used analgesics are not effective and may cause side effects. Recent studies highlight the role of chemokines in neuropathy and their potential as analgesic targets. Chemokine receptors can be blocked or inhibited to relieve neuropathic pain and enhance opioid analgesia. Multi-target chemokine receptor antagonists have also shown promise as effective painkillers. Modulating the chemokine family can greatly improve the lives of neuropathic pain patients.
Article
Nanoscience & Nanotechnology
Christina Schmitt, Anna Lechanteur, Francois Cossais, Coralie Bellefroid, Philipp Arnold, Ralph Lucius, Janka Held-Feindt, Geraldine Piel, Kirsten Hattermann
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Vivian Adamski, Kirsten Hattermann, Carolin Kubelt, Gesa Cohrs, Ralph Lucius, Michael Synowitz, Susanne Sebens, Janka Held-Feindt
Article
Engineering, Biomedical
Christina Schmitt, Florian Rasch, Francois Cossais, Janka Held-Feindt, Ralph Lucius, Adrian Romani Vazquez, Ali Shaygan Nia, Martin R. Lohe, Xinliang Feng, Yogendra K. Mishra, Rainer Adelung, Fabian Schutt, Kirsten Hattermann
Summary: Brain implants using graphene-based scaffolds show promising potential for a wide range of nervous tissue diseases. Studies have found that these scaffolds have slight effects on glial cell populations, which are important in scar formation, and these effects can be eliminated by curcumin, suggesting a possible protective application for brain implants.
BIOMEDICAL MATERIALS
(2021)
Article
Medical Laboratory Technology
Guranda Chitadze, Marcus Lettau, Christian Peters, Stefanie Luecke, Charlotte Flueh, Elgar Susanne Quabius, Michael Synowitz, Janka Held-Feindt, Dieter Kabelitz
Summary: The study revealed false positive reactivity of PE-labeled anti-NKG2D antibody 149810 on granulocytes from dexamethasone-treated GBM patients, while no such reactivity was observed with the APC-labeled or unconjugated version of the same clone.
CYTOMETRY PART B-CLINICAL CYTOMETRY
(2022)
Article
Biochemistry & Molecular Biology
Deniz Caylioglu, Rieke Johanna Meyer, Dana Hellmold, Carolin Kubelt, Michael Synowitz, Janka Held-Feindt
Summary: The study demonstrates the potent cytotoxic effects of AT101 on GBM stem-like cells, especially upon co-culture with stem-like cell-conditioned medium. This treatment approach may prevent GBM recurrences by inhibiting specific signaling pathways and regulating receptor expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Marie N. M. Volmar, Jiying Cheng, Haitham Alenezi, Sven Richter, Alisha Haug, Zonera Hassan, Maria Goldberg, Yuping Li, Mengzhuo Hou, Christel Herold-Mende, Cecile L. Maire, Katrin Lamszus, Charlotte Flueh, Janka Held-Feindt, Gaetano Gargiulo, Geoffrey J. Topping, Franz Schilling, Dieter Saur, Gunter Schneider, Michael Synowitz, Joel A. Schick, Roland E. Kalin, Rainer Glass
Summary: The study reveals that CBD can convert NF-kappa B into a tumor suppressor, sensitizing a cohort of tumors with low levels of reactive oxygen species to CBD-induced cell death, while high ROS levels in other tumors block this effect.
Article
Critical Care Medicine
Gesa Cohrs, Ann-Kathrin Blumenroether, Jan-Philip Suerie, Michael Synowitz, Janka Held-Feindt, Friederike Knerlich-Lukoschus
Summary: This study investigated the cellular and molecular mechanisms underlying the functional decline in myelomeningocele (MMC) placodes using a retinoic acid-induced MMC rat model. The findings showed inflammatory cells and glial activation in later gestational stages, along with significant changes in cytokine expression levels at different embryonic stages. These results contribute to understanding the pathophysiological mechanisms and potential therapeutic targets for open spinal dysraphism.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Carolin Kubelt, Henri Molkewehrum, Ralph Lucius, Michael Synowitz, Janka Held-Feindt, Ann-Kristin Helmers
Summary: Deep brain stimulation appears to modulate inflammatory processes, with controversial effects on the induction or suppression of inflammatory mediators. An in-vitro model simulating clinical stimulation patterns showed induced expression of inflammatory mediators by electrical stimulation in specific brain cell lines.
NEUROMOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Margarethe Hauck, Jan Dittmann, Berit Zeller-Plumhoff, Roshani Madurawala, Dana Hellmold, Carolin Kubelt, Michael Synowitz, Janka Held-Feindt, Rainer Adelung, Stephan Wulfinghoff, Fabian Schuett
Summary: Localized therapy approaches have emerged as an alternative route to overcome the limitations of systemic therapies. To achieve effective treatment, the release kinetics of drug delivery systems (DDS) need to be controlled. This study presents a computationally supported reservoir-based DDS development for patient-specific release kinetics, allowing for precise adaptation of release profiles.
Editorial Material
Cell Biology
Friederike Knerlich-Lukoschus
NEURAL REGENERATION RESEARCH
(2023)
Article
Engineering, Biomedical
Dana Hellmold, Pietro Arnaldi, Michael Synowitz, Janka Held-Feindt, Mohsen Akbari
Summary: Current treatment strategies for GBM have limited effectiveness, so there is a need for more effective treatments. A localized drug delivery system called AT101-GlioMesh, which releases the drug AT101 at the tumor site, has shown promising results in inhibiting tumor recurrence and inducing cytotoxic effects on GBM cell lines.
BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Dana Hellmold, Carolin Kubelt, Tina Daunke, Silje Beckinger, Ottmar Janssen, Margarethe Hauck, Fabian Schuett, Rainer Adelung, Ralph Lucius, Jochen Haag, Susanne Sebens, Michael Synowitz, Janka Held-Feindt
Summary: Glioblastoma (GBM) is a difficult-to-treat disease with high resistance to chemotherapy and radiotherapy. This study investigated the chemoresistance mechanisms of surviving GBM cells and the effects of combination therapy with temozolomide (TMZ) and AT101. The results showed that while the combination therapy was highly efficient, it led to the predominance of phosphatidylserine-positive GBM cells over time. Analysis revealed phosphorylation of AKT, mTOR, and GSK3beta, resulting in the induction of pro-tumorigenic genes in surviving GBM cells. Treatment with Torin2 partially counteracted the observed effects, and the combination therapy also altered the composition of extracellular vesicles released from surviving GBM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Carolin Kubelt, Dana Hellmold, Daniela Esser, Hajrullah Ahmeti, Michael Synowitz, Janka Held-Feindt
Summary: Our study reveals the involvement of CCRL1, SLFN13, SKI, Cables1, and DCHS1 in TMZ-promoted dormancy in glioblastoma. These genes are associated with stemness, with SKI being particularly important. Inhibition of SKI during TMZ treatment shows increased cytotoxicity, proliferation inhibition, and decreased neurosphere formation capacity.
Article
Biochemistry & Molecular Biology
Carolin Kubelt, Dana Hellmold, Eva Peschke, Margarethe Hauck, Olga Will, Fabian Schuett, Ralph Lucius, Rainer Adelung, Regina Scherliess, Jan-Bernd Hoevener, Olav Jansen, Michael Synowitz, Janka Held-Feindt
Summary: Local drug delivery systems (LDDS) are potential therapies for glioblastoma (GBM), but their success has been limited. Establishing GBM animal models is crucial for evaluating LDDS, but few reports detail the process. In this study, a partial resection glioma model in rats was successfully established and used to evaluate the efficiency of LDDS. The results provide a powerful tool for future testing of these promising systems in clinical applications.
Article
Multidisciplinary Sciences
Josh P. Peters, Arne Brahms, Vivian Janicaud, Maria Anikeeva, Eva Peschke, Frowin Ellermann, Arianna Ferrari, Dana Hellmold, Janka Held-Feindt, Na-mi Kim, Johannes Meiser, Konrad Aden, Rainer Herges, Jan-Bernd Hoevener, Andrey N. Pravdivtsev
Summary: By using dissolution dynamic nuclear polarization (dDNP), the sensitivity of magnetic resonance imaging is enhanced by over 10,000 times, allowing for noninvasive real-time in vivo metabolic imaging. Here, a group of dDNP polarized tracers based on nicotinamide (NAM) are being developed.