5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology

Enhanced production of 5-hydroxytryptophan through the regulation of L-tryptophan biosynthetic pathway

(2020) Da Xu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Efficacy and safety of the 5‐Hydroxytryptophan on Depression and Apathy in Parkinson's disease: a preliminary finding

(2020) Mario Meloni et al.   EUROPEAN JOURNAL OF NEUROLOGY

Bioprocess Optimization for the Production of Aromatic Compounds With Metabolically Engineered Hosts: Recent Developments and Future Challenges

(2020) Adelaide Braga et al.   Frontiers in Bioengineering and Biotechnology

Identification and Quantification of Oxidation Products in Full-Length Biotherapeutic Antibodies by NMR Spectroscopy

(2020) Arthur Hinterholzer et al.   ANALYTICAL CHEMISTRY

Microfluidic neurotransmitters sensor in blood plasma with mediator-immobilized conducting polymer/N, S-doped porous carbon composite

(2020) Kyeong-Deok Seo et al.   SENSORS AND ACTUATORS B-CHEMICAL

Microbial Synthesis of Human-Hormone Melatonin at Gram Scales

(2020) Hao Luo et al.   ACS Synthetic Biology

Physiological and pharmacological perspectives of melatonin

(2020) Saptadip Samanta   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Biotechnological production of lycopene by microorganisms

(2020) Lei Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies

(2020) Massimo E. Maffei   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simultaneous determination of melatonin and 5-hydroxytrptophan at the disposable poly-(melamine)/poly-(o-aminophenol) composite modified screen printed sensor

(2020) Neeraj Kumar et al.   JOURNAL OF ELECTROANALYTICAL CHEMISTRY

Chemical Characterization and DNA Fingerprinting of Griffonia simplicifolia Baill.

(2019) Ivano Vigliante et al.   MOLECULES

The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice

(2019) James Francescangeli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rumen-Protected 5-Hydroxytryptophan Improves Sheep Melatonin Synthesis in the Pineal Gland and Intestinal Tract

(2019) Fang Zhao et al.   MEDICAL SCIENCE MONITOR

Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review

(2019) Erik Höglund et al.   Frontiers in Endocrinology

Increase in serotonin precursor levels reinstates the context memory during reconsolidation

(2019) Alena B. Zuzina et al.   INVERTEBRATE NEUROSCIENCE

Bioactive Amines Screening in Four Genotypes of Thermally Processed Cauliflower

(2019) Diamante et al.   Antioxidants

Metabolic Engineering Strategies for Sustainable Terpenoid Flavor and Fragrance Synthesis

(2019) Xixian Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Catecholamine and Indolamine Pathway: A Case–Control Study in Fibromyalgia

(2018) Alma Rus et al.   Biological Research for Nursing

Metabolic pathway engineering for high-level production of 5-hydroxytryptophan in Escherichia coli

(2018) Haijiao Wang et al.   METABOLIC ENGINEERING

Structure determination of disease associated peak AAA from l -Tryptophan implicated in the eosinophilia-myalgia syndrome

(2018) Klaus Klarskov et al.   TOXICOLOGY LETTERS

Peripheral Serotonin Synthesis as a New Drug Target

(2018) Susann Matthes et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synthetic pathways and processes for effective production of 5-hydroxytryptophan and serotonin from glucose in Escherichia coli

(2018) José-Aníbal Mora-Villalobos et al.   Journal of Biological Engineering

Time course of l -tryptophan metabolites when fermenting natural grape musts: effect of inoculation treatments and cultivar on the occurrence of melatonin and related indolic compounds

(2018) E. Fernández-Cruz et al.   AUSTRALIAN JOURNAL OF GRAPE AND WINE RESEARCH

Metabolic analysis of the melatonin biosynthesis pathway using chemical labeling coupled with liquid chromatography-mass spectrometry

(2018) Tiantian Ye et al.   JOURNAL OF PINEAL RESEARCH

Simultaneous determination of tryptophan and 8 metabolites in human plasma by liquid chromatography/tandem mass spectrometry

(2017) Lysiane Boulet et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

An Open-Label Pilot Study of Combined Augmentation With Creatine Monohydrate and 5-Hydroxytryptophan for Selective Serotonin Reuptake Inhibitor– or Serotonin-Norepinephrine Reuptake Inhibitor–Resistant Depression in Adult Women

(2017) Brent M. Kious et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Trace level determination of 5-hydroxytryptamine and its related indoles in amniotic fluid by gas chromatography–mass spectrometry

(2017) Hongmei Shi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Palladium nano particles decorated multi-walled carbon nanotubes modified sensor for the determination of 5-hydroxytryptophan in biological fluids

(2017) Neeraj Kumar et al.   SENSORS AND ACTUATORS B-CHEMICAL

Elevating serotonin pre-partum alters the Holstein dairy cow hepatic adaptation to lactation

(2017) Samantha R. Weaver et al.   PLoS One

Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors

(2016) Daniel R. Goldberg et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hydrophilic interaction chromatography combined with dispersive liquid–liquid microextraction as a preconcentration tool for the simultaneous determination of the panel of underivatized neurotransmitters in human urine samples

(2016) Lucyna Konieczna et al.   JOURNAL OF CHROMATOGRAPHY A

Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae

(2016) Jiantao Zhang et al.   Molecular BioSystems

A sensitive electrochemical method for the determination of 5-hydroxytryptophan in rats' brain tissue based on a carbon nanosheets-modified electrode

(2015) Yahong Chen et al.   Analytical Methods

A Medical Food Formulation ofGriffonia simplicifolia/Magnesium for Childhood Periodic Syndrome Therapy: An Open-Label Study on Motion Sickness

(2015) Maria Esposito et al.   JOURNAL OF MEDICINAL FOOD

Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis

(2015) Tao-Hsiang Yang et al.   ARTHRITIS RESEARCH & THERAPY

The chemical logic of plant natural product biosynthesis

(2014) Gülbenk Anarat-Cappillino et al.   CURRENT OPINION IN PLANT BIOLOGY

A Rapid and Simple Method for Determination of 5-Hydroxytryptophan in Dietary Supplements by Capillary Electrophoresis

(2014) Aline G. Coelho et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Engineering Bacterial Phenylalanine 4-Hydroxylase for Microbial Synthesis of Human Neurotransmitter Precursor 5-Hydroxytryptophan

(2014) Yuheng Lin et al.   ACS Synthetic Biology

Precursor-Directed Biosynthesis of 5-Hydroxytryptophan Using Metabolically Engineered E. coli

(2014) Xinxiao Sun et al.   ACS Synthetic Biology

Analysis of 5-hydroxytryptophan in the presence of excipients from dietary capsules: comparison between cyclic voltammetry and UV visible spectroscopy

(2013) Isabel J. Tunna et al.   Analytical Methods

Analysis of indole compounds in methanolic extracts from the fruiting bodies of Cantharellus cibarius (the Chanterelle) and from the mycelium of this species cultured in vitro

(2013) Bożena Muszyńska et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Modular optimization of multi-gene pathways for fatty acids production in E. coli

(2013) Peng Xu et al.   Nature Communications

Enhanced synthesis of 5-hydroxy-l-tryptophan through tetrahydropterin regeneration

(2013) Ryotaro Hara et al.   AMB Express

Chromatographic assay to study the activity of multiple enzymes involved in the synthesis and metabolism of dopamine and serotonin

(2012) Lindsay D. Morgan et al.   ANALYST

Quantitative analysis of multiple urinary biomarkers of carcinoid tumors through gold-nanoparticle-assisted laser desorption/ionization time-of-flight mass spectrometry

(2011) Tsung-Rong Kuo et al.   ANALYTICA CHIMICA ACTA

Determination of serotonin and its precursors in chocolate samples by capillary liquid chromatography with mass spectrometry detection

(2011) V. Guillén-Casla et al.   JOURNAL OF CHROMATOGRAPHY A

Pyrolytic graphite electrode modified with a thin film of a graphite/diamond nano-mixture for highly sensitive voltammetric determination of tryptophan and 5-hydroxytryptophan

(2011) Saeed Shahrokhian et al.   MICROCHIMICA ACTA

Influence of Griffonia simplicifolia on male sexual behavior in rats: Behavioral and neurochemical study

(2011) G. Carnevale et al.   PHYTOMEDICINE

Anxiolytic-like effect of Griffonia simplicifolia Baill. seed extract in rats

(2011) G. Carnevale et al.   PHYTOMEDICINE

Single Turnover Kinetics of Tryptophan Hydroxylase: Evidence for a New Intermediate in the Reaction of the Aromatic Amino Acid Hydroxylases

(2010) Jorge Alex Pavon et al.   BIOCHEMISTRY

Indole compounds in fruiting bodies of some edible Basidiomycota species

(2010) Bożena Muszyńska et al.   FOOD CHEMISTRY

5-Hydroxytrytophan Inhibitstert-Butylhydroperoxide (t-BHP)-Induced Oxidative Damage via the Suppression of Reactive Species (RS) and Nuclear Factor-κB (NF-κB) Activation on Human Fibroblast

(2010) Sung Jin Bae et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oxidation and flow-injection amperometric determination of 5-hydroxytryptophan at an electrode modified by electrochemically assisted deposition of a sol–gel film with templated nanoscale pores

(2010) David Ranganathan et al.   TALANTA

5-Hydroxytryptophan Acts on the Mitogen-Activated Protein Kinase Extracellular-Signal Regulated Protein Kinase Pathway to Modulate Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in RAW 264.7 Cells

(2009) Hee-Sung Chae et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

FolX and FolM Are Essential for Tetrahydromonapterin Synthesis in Escherichia coli and Pseudomonas aeruginosa

(2009) A. Pribat et al.   JOURNAL OF BACTERIOLOGY

Enhancement of l-tryptophan 5-hydroxylation activity by structure-based modification of l-phenylalanine 4-hydroxylase from Chromobacterium violaceum

(2009) Kuniki Kino et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Ultrasensitive detection of indoleamines by combination of nanoparticle-based extraction with capillary electrophoresis/laser-induced native fluorescence

(2009) Mu-De Li et al.   JOURNAL OF CHROMATOGRAPHY A

Effects of Tryptophan and 5-Hydroxytryptophan on the Hepatic Cell Membrane Rigidity Due to Oxidative Stress

(2009) M. C. Reyes-Gonzales et al.   JOURNAL OF MEMBRANE BIOLOGY

Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

(2008) Q. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa

(2008) LJCA Smarius et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland

(2007) Roseli Barbosa et al.   LIFE SCIENCES