Article
Neurosciences
Patsorn Wichit, Sekh Thanprasertsuk, Onanong Phokaewvarangkul, Roongroj Bhidayasiri, Saknan Bongsebandhu-Phubhakdi
Summary: The study found that PD patients had higher plasma norepinephrine levels but lower epinephrine and serotonin levels compared to control subjects. Additionally, PD patients showed a significantly higher HVA/DA ratio and lower VMA/NE ratio. The levels of different monoamines were associated with clinical profiles in PD patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Chemistry, Physical
O. A. Mostovaya, P. L. Padnya, D. N. Shurpik, I. E. Shiabiev, I. I. Stoikov
Summary: The study focuses on utilizing p-tert-butylthiacalix[4]arene as a macrocyclic scaffold to design and synthesize dendrimer-like compounds. By modifying the macrocycle with fragments containing amide and lactide groups, original analogs of dendrimers with symmetric and asymmetric structures can be obtained. The 1,3-alternate conformation is found to be most favorable for binding catechol-amines, while the cone conformation shows selectivity in binding epinephrine and norepinephrine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Cell Biology
Elise Lelou, Anne Corlu, Nicolas Nesseler, Claudine Rauch, Yannick Malledant, Philippe Seguin, Caroline Aninat
Summary: In recent years, there has been an increasing number of research publications on the role of catecholamines in liver diseases. However, the mechanisms behind these effects are not well understood. This review focuses on the interaction between the liver and catecholamines, the expression of adrenergic and dopaminergic receptors in liver cells, and the involvement of catecholamines in physiological and pathophysiological processes. The importance of understanding these mechanisms for potential therapeutic use of adrenergic and dopaminergic antagonists is highlighted.
Review
Neurosciences
Cooper D. Grossman, Jeremiah Y. Cohen
Summary: This article discusses the evolution of nervous systems to adapt to the dynamics of the environment and explains this process through the study of learning and decision-making. The article focuses on the slow dynamics of neuronal networks and the role of neuromodulators in temporal scaling.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Review
Chemistry, Analytical
Zina Fredj, Mohamad Sawan
Summary: Catecholamines are crucial neurotransmitters in the central nervous system and play key roles in neurological disorders. Optical and electrochemical biosensors have been widely adopted for the real-time monitoring of catecholamine neurotransmitters and their development has been greatly accelerated in the last decade. This review provides a comprehensive overview on the recent advances and main challenges in catecholamines biosensors, with emphasis on electrochemical biosensors and the unique characteristics brought by nanotechnology. It also summarizes the therapeutic use of nanomaterials for catecholamine analysis and future development trends based on specific biosensors' performance metrics.
Article
Peripheral Vascular Disease
Kosuke Inoue, Tamara Horwich, Roshni Bhatnagar, Karan Bhatt, Deena Goldwater, Teresa Seeman, Karol E. Watson
Summary: Higher levels of urinary stress hormones were associated with an increased risk of incident hypertension in this multiethnic population study. Urinary cortisol levels were also found to be associated with an increased risk of incident cardiovascular events. These findings suggest a potential important role of stress hormones in the prevention and treatment of hypertension and cardiovascular diseases.
Article
Pharmacology & Pharmacy
Heidi N. Boyda, Michelle Pham, Joyce Huang, Amanzo A. Ho, Ric M. Procyshyn, Jessica W. Y. Yuen, William G. Honer, Alasdair M. Barr
Summary: This study examined the role of peripheral catecholamines in antipsychotic-induced glucose intolerance and found a significant association between increased peripheral catecholamines and glucose intolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Courtney S. Wilkinson, Harrison L. Blount, Marek Schwendt, Lori A. Knackstedt
Summary: This study used a rat model of PTSD to investigate the effects of stress on monoamine concentrations in brain regions associated with PTSD in female rats. The findings indicate that stress exposure can lead to long-term alterations in monoamine function in female rats, suggesting potential interventions using MAOIs as a treatment for PTSD in women.
Article
Pharmacology & Pharmacy
Stephen Daniels, Mostafa El Mansari, Rami Hamoudeh, Pierre Blier
Summary: Ketamine exerts its antidepressant effects by modulating neuronal activity, enhancing dopamine neuronal activity and normalizing norepinephrine neuronal activity in the locus coeruleus and ventral tegmental area.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Clinical Neurology
Sayed Ausim Azizi
Summary: Monoamines play important roles in regulating brain function and have both physiological and pathological significance in influencing perception and behavior.
Article
Clinical Neurology
Greg C. Bristow, Tory Eisenlohr-Moul, Krista Lotesto, Monsheel S. Sodhi
Summary: This study found gender differences in the transcription of monoaminergic genes in the DLPFC in MDD patients, indicating that abnormalities in the expression of monoaminergic genes may contribute to alterations in DLPFC activity observed in major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Chemistry, Analytical
Cristina Tortolini, Anthony E. G. Cass, Riccardo Pofi, Andrea Lenzi, Riccarda Antiochia
Summary: The study introduces a microneedle-based sensor using highly nanoporous gold for continuous monitoring of catecholamines in interstitial fluid, displaying low detection limit, excellent sensitivity and stability, and fast response time. The performance of the sensor was evaluated in artificial interstitial fluid and a hydrogel skin model at typical physiological concentrations.
Article
Clinical Neurology
Chidiebere M. Iro, Rami Hamati, Mostafa El Mansari, Pierre Blier
Summary: The firing activity of monoamine neurons did not change 1 day after a single ketamine injection, but showed robust increases in NE neurons and enhancement in DA neurons after repeated administration. The increased activity of NE neurons was no longer present 3 days after the last injection, while that of DA neurons remained. This suggests that the enhanced activity of NE and DA neurons may play a significant role in maintaining the antidepressant action of ketamine.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Esteban Obrero-Gaitan, Francisco Molina, Maria-de-Alharilla Montilla-Ibanez, Rafael Del-Pino-Casado, Daniel Rodriguez-Almagro, Rafael Lomas-Vega
Summary: The study aimed to assess the misperception of visual verticality in patients with peripheral vestibular disorders compared to healthy controls. Results from 34 studies showed that patients with PVD have a higher misperception of VV, particularly in the acute phase and after vestibular surgery.
Article
Biology
Maria Encarnacion Aguilar-Ferrandiz, Antonio Casas-Barragan, Rosa Maria Tapia-Haro, Alma Rus, Francisco Molina, Maria Correa-Rodriguez
Summary: This study found that women with fibromyalgia had higher tympanic core body and hand temperature compared to healthy controls. Negative associations between hand peripheral vasodilation and NO were observed in healthy women but not in those with fibromyalgia, suggesting dysfunction of sympathetic cutaneous neural control.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Nursing
Maria Encarnacion Aguilar-Ferrandiz, Antonio Casas-Barragan, Alma Rus, Rosa Maria Tapia-Haro, Jose Manuel Martinez-Martos, Francisco Molina, Maria Correa-Rodriguez
Summary: Our study found significant relationships between serum nitric oxide levels, oxytocinase activity, and enkephalin-degrading aminopeptidase (EDA) activity with pain-related indicators in women with fibromyalgia (FM).
Article
Nursing
Maria Correa-Rodriguez, Blanca Rueda-Medina, Antonio Casas-Barragan, Rosa Maria Tapia-Haro, Francisco Molina, Maria Encarnacion Aguilar-Ferrandiz
Summary: The study revealed that lower intake of certain micronutrients in the diet of women with fibromyalgia correlated with higher symptom severity and pain levels, emphasizing the potential relevance of these micronutrients in the condition.
CLINICAL NURSING RESEARCH
(2021)
Article
Nursing
Alma Rus, Francisco Molina, Maria Victoria Camacho, Mercedes La Rubia, Maria Encarnacion Aguilar-Ferrandiz, Maria Luisa del Moral
Summary: The aim of this study was to evaluate the predictive ability of various laboratory parameters in distinguishing patients with fibromyalgia (FM) from healthy subjects. The results showed significant differences in several blood parameters between the FM patients and the control group. Receiver operating characteristic analysis suggested that these parameters could assist in diagnosing FM.
CLINICAL NURSING RESEARCH
(2023)
Review
Clinical Neurology
Sabina de la Paz Bengoechea-Fortes, Maria Jesus Ramirez-Exposito, Jose Manuel Martinez-Martos
Summary: Suicide is a major public health problem worldwide and the second leading cause of death in the 15-29 age group. The present narrative review explores important aspects of suicide, including risk factors and physiological findings that can contribute to understanding this phenomenon. Objective measures, such as increased neuroinflammation, hyperactivity of the hypothalamic-pituitary-adrenal axis, and alterations in serotonin and vitamin D levels, have been found in individuals who have died by suicide. This review highlights the need for multidisciplinary approaches to address suicide and raise awareness of its significance.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Alma Rus, Jose Alberto Lopez-Sanchez, Jose Manuel Martinez-Martos, Maria Jesus Ramirez-Exposito, Francisco Molina, Maria Correa-Rodriguez, Maria Encarnacion Aguilar-Ferrandiz
Summary: This study evaluated circulating free amino acid (AA) levels in fibromyalgia patients and found an imbalance in most AAs, suggesting a metabolic disturbance in fibromyalgia. Determining the serum levels of these AAs may aid in the diagnosis of fibromyalgia.
MOLECULAR DIAGNOSIS & THERAPY
(2023)
Article
Genetics & Heredity
Cristina Cueto-Urena, Maria Jesus Ramirez-Exposito, Maria Dolores Mayas, Maria Pilar Carrera-Gonzalez, Alicia Godoy-Hurtado, Jose Manuel Martinez-Martos
Summary: Extensive research efforts in brain tumor studies have led to the reclassification of tumors by WHO and the identification of molecular subtypes. The imbalances in antioxidant defense systems, leading to excessive production of reactive oxygen species, have been recognized as key mechanisms contributing to tumor initiation. This study investigated the gene expression patterns of glutathione peroxidase isoforms in brain tissue obtained from rats, revealing elevated expression levels in tumor tissue and gender differences in expression profiles.
Review
Biochemistry & Molecular Biology
Maria Pilar Carrera-Gonzalez, Maria Jesus Ramirez-Exposito, Carmen Guerrero-Gonzalez, Jose Manuel Martinez-Martos
Summary: One of the diseases associated with the aging population is Alzheimer's disease, which lacks effective diagnosis biomarkers or treatments. Given its higher prevalence in women, it is important to study systems and pathways that might contribute to its development, such as the brain renin-angiotensin system and its regulatory enzymes. This system, modulated by estrogens, is connected with cerebral glucose metabolism through the angiotensin IV receptor, known as IRAP. Understanding the connection between these elements may offer insights into the molecular mechanisms of Alzheimer's disease and lead to new diagnostic and therapeutic targets.
AIMS MOLECULAR SCIENCE
(2023)
Proceedings Paper
Computer Science, Hardware & Architecture
S. Wane, F. Ferrero, J. Sombrin, L. Tombakdjian, D. Bajon, P. Ratajczak, F. Molina, M. Rack, L. Nyssens, J-P Raskin, D. Lederer, C. Craeye, G. Albertini, V Huard, P. Poilvert, C-A Tavernier, D. Floriot
Summary: This paper proposes hybrid GaN-FDSOI Front-End-Modules (FEMs) combined with lens-based mmWave antenna modules for energy-efficient multibeamforming systems. Balanced and unbalanced differential switches are designed and fabricated using FDSOI platforms for building scalable multibeamforming FEMs. Unified mmWave and Baseband correlation technologies based on energy density and EVM metrics are introduced for low complexity cost-effective multi-beamforming systems.
PROCEEDINGS OF THE 2022 IEEE TEXAS SYMPOSIUM ON WIRELESS AND MICROWAVE CIRCUITS AND SYSTEMS (WMCS)
(2022)
Article
Pharmacology & Pharmacy
Antonio Casas-Barragan, Francisco Molina, Rosa Maria Tapia-Haro, Maria Carmen Garcia-Rios, Maria Correa-Rodriguez, Maria Encarnacion Aguilar-Ferrandiz
Summary: The study found significant correlations between body core temperature and hand temperature with clinical symptoms in FMS patients.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)