Physiological and pharmacological perspectives of melatonin

Melatonin Synthesis and Function: Evolutionary History in Animals and Plants

(2019) Dake Zhao et al.   Frontiers in Endocrinology

The use of melatonin in adult psychiatric disorders: Expert recommendations by the French institute of medical research on sleep (SFRMS)

(2019) P.A. Geoffroy et al.   ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE

Pineal gland dysfunction in Alzheimer’s disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis

(2019) Juhyun Song   Molecular Neurodegeneration

Melatonin: Countering Chaotic Time Cues

(2019) Josephine Arendt   Frontiers in Endocrinology

Melatonin: A Molecule for Reducing Breast Cancer Risk

(2018) et al.   MOLECULES

Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation of the Pineal Gland

(2018) Dun Tan et al.   MOLECULES

Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial

(2018) Tracey L. Sletten et al.   PLOS MEDICINE

Ocular and systemic melatonin and the influence of light exposure

(2018) Lisa A Ostrin   Clinical and Experimental Optometry

Mechanisms Underlying Tumor Suppressive Properties of Melatonin

(2018) Stephen C. Bondy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Influences Structural Plasticity in the Axons of Granule Cells in the Dentate Gyrus of Balb/C Mice

(2018) Gerardo Ramírez-Rodríguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Docking studies for melatonin receptors

(2017) Hanan Awad Alkozi et al.   Expert Opinion on Drug Discovery

Dynamin-related protein 1-mediated mitochondrial fission contributes to post-traumatic cardiac dysfunction in rats and the protective effect of melatonin

(2017) Mingge Ding et al.   JOURNAL OF PINEAL RESEARCH

N,N-dimethyltryptamine and the pineal gland: Separating fact from myth

(2017) David E Nichols   JOURNAL OF PSYCHOPHARMACOLOGY

A review of sleep disorders and melatonin

(2017) Zizhen Xie et al.   NEUROLOGICAL RESEARCH

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

(2017) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variation of clock genes and cancer risk: a field synopsis and meta-analysis

(2017) Clara Benna et al.   Oncotarget

Endogenous Melatonin is Not Obligatory for the Regulation of the Rat Sleep-Wake Cycle

(2017) Simon P. Fisher et al.   SLEEP

The Use of Exogenous Melatonin in Delayed Sleep Phase Disorder: A Meta-analysis

(2017) Ingeborg M. van Geijlswijk et al.   SLEEP

MT1and MT2Melatonin Receptors: A Therapeutic Perspective

(2016) Jiabei Liu et al.   Annual Review of Pharmacology and Toxicology

Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats

(2016) Jana Tchekalarova et al.   BEHAVIOURAL BRAIN RESEARCH

Update on melatonin receptors: IUPHAR Review 20

(2016) Ralf Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

(2016) Tiinamaija Tuomi et al.   Cell Metabolism

Impact of Common Diabetes Risk Variant inMTNR1Bon Sleep, Circadian, and Melatonin Physiology

(2016) Jacqueline M. Lane et al.   DIABETES

Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures

(2016) Gregory D. M. Potter et al.   ENDOCRINE REVIEWS

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

(2016) Dun-Xian Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer metastasis: Mechanisms of inhibition by melatonin

(2016) Shih-Chi Su et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4-phenylpyridinium treatment

(2016) Jih-Ing Chuang et al.   JOURNAL OF PINEAL RESEARCH

Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Melatonin Signal Transduction Pathways Require E-Box-Mediated Transcription of Per1 and Per2 to Reset the SCN Clock at Dusk

(2016) Patty C. Kandalepas et al.   PLoS One

Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging

(2016) Michael A. Paltsev et al.   Oncotarget

Effect of Melatonin and Calmodulin in an Idiopathic Scoliosis Model

(2016) Jun-Zhe Wu et al.   Biomed Research International

Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats

(2016) Irina A. Vinogradova et al.   Aging-US

Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks

(2016) Sharon Owino et al.   PLoS One

Cellular Basis of Pineal Gland Development: Emerging Role of Microglia as Phenotype Regulator

(2016) María P. Ibañez Rodriguez et al.   PLoS One

Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5′ adenosine monophosphate-activated protein kinase pathway

(2015) Sheng Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Melatonin: an inhibitor of breast cancer

(2015) S. M. Hill et al.   ENDOCRINE-RELATED CANCER

Melatonin Stimulates Dendrite Formation and Complexity in the Hilar Zone of the Rat Hippocampus: Participation of the Ca++/Calmodulin Complex

(2015) Aline Domínguez-Alonso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prospective Study on Salivary Evening Melatonin and Sleep before and after Pinealectomy in Humans

(2015) Helen Slawik et al.   JOURNAL OF BIOLOGICAL RHYTHMS

GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin

(2015) L. M. Hablitz et al.   JOURNAL OF NEUROSCIENCE

Melatonin treatment improves primary progressive multiple sclerosis: a case report

(2015) Antonio López-González et al.   JOURNAL OF PINEAL RESEARCH

Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation

(2015) Jia-Yi Wei et al.   JOURNAL OF PINEAL RESEARCH

Exogenous melatonin for sleep disorders in neurodegenerative diseases: a meta-analysis of randomized clinical trials

(2015) Wei Zhang et al.   NEUROLOGICAL SCIENCES

System Consolidation During Sleep – A Common Principle Underlying Psychological and Immunological Memory Formation

(2015) Jürgen Westermann et al.   TRENDS IN NEUROSCIENCES

Melatonin prevents hyperglycemia in a model of sleep apnea

(2015) Renata Schenkel Rivera Kaminski et al.   Archives of Endocrinology Metabolism

Getting rhythm: how do babies do it?

(2014) Desaline Joseph et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Melatonin protects against behavioural dysfunctions and dendritic spine damage in 3-nitropropionic acid-induced rat model of Huntington's disease

(2014) J. Chakraborty et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial

(2014) Melissa V. Hansen et al.   BREAST CANCER RESEARCH AND TREATMENT

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypothalamic Subependymal Niche: A Novel Site of the Adult Neurogenesis

(2014) Ewa Rojczyk-Gołębiewska et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Is melatonin ready to be used in preterm infants as a neuroprotectant?

(2014) Valérie Biran et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

The therapeutic or prophylactic effect of exogenous melatonin against depression and depressive symptoms: A systematic review and meta-analysis

(2014) M.V. Hansen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Therapeutic Effects of Melatonin Receptor Agonists on Sleep and Comorbid Disorders

(2014) Moshe Laudon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association Between Urinary 6-Sulfatoxymelatonin Excretion and Arterial Stiffness in the General Elderly Population: The HEIJO-KYO Cohort

(2014) Kenji Obayashi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats

(2014) Hang-Mee Yeung et al.   JOURNAL OF PINEAL RESEARCH

Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study

(2014) Jan M. Bumb et al.   JOURNAL OF SLEEP RESEARCH

Melatonin enhances adult rat hippocampal progenitor cell proliferation via ERK signaling pathway through melatonin receptor

(2014) C. Tocharus et al.   NEUROSCIENCE

Melatonin, selective and non-selective MT1/MT2 receptors agonists: Differential effects on the 24-h vigilance states

(2014) Rafael Ochoa-Sanchez et al.   NEUROSCIENCE LETTERS

Physiology and pharmacology of melatonin in relation to biological rhythms

(2014) Jolanta B. Zawilska et al.   Pharmacological Reports

Melatonin: Exceeding Expectations

(2014) Russel J. Reiter et al.   PHYSIOLOGY

Sleep–wake characterization of double MT1/MT2 receptor knockout mice and comparison with MT1 and MT2 receptor knockout mice

(2013) Stefano Comai et al.   BEHAVIOURAL BRAIN RESEARCH

Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63

(2013) Lifeng Liu et al.   BONE

A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder: Effects on subjective and objective sleep

(2013) Ingvild West Saxvig et al.   CHRONOBIOLOGY INTERNATIONAL

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

(2013) Mariano Bizzarri et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives

(2013) Sylvie Tordjman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Receptor Genes in Vertebrates

(2013) Di Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Melatonin in Schizophrenia

(2013) Armando Morera-Fumero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immune-Pineal Axis: Nuclear Factor κB (NF-kB) Mediates the Shift in the Melatonin Source from Pinealocytes to Immune Competent Cells

(2013) Regina Markus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin: Buffering the Immune System

(2013) Antonio Carrillo-Vico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells

(2013) Marco A. Pires-Lapa et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates methamphetamine-induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH-SY5Y cells

(2013) Arisa Parameyong et al.   JOURNAL OF PINEAL RESEARCH

Assessment and Management of Sleep Problems in Youths With Attention-Deficit/Hyperactivity Disorder

(2013) Samuele Cortese et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Autism

(2013) Meng-Chuan Lai et al.   LANCET

Role of sleep in the regulation of the immune system and the pituitary hormones

(2012) Beatriz Gómez-González et al.   Annals of the New York Academy of Sciences

Tired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?

(2012) Cecilia Nagorny et al.   Current Diabetes Reports

Endothelial cell adhesiveness is a function of environmental lighting and melatonin level

(2012) Marina Marçola et al.   JOURNAL OF PINEAL RESEARCH

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

NF-κB Drives the Synthesis of Melatonin in RAW 264.7 Macrophages by Inducing the Transcription of the Arylalkylamine-N-Acetyltransferase (AA-NAT) Gene

(2012) Sandra Marcia Muxel et al.   PLoS One

Repeated Melatonin Supplementation Improves Sleep in Hypertensive Patients Treated with Beta-Blockers: A Randomized Controlled Trial

(2012) Frank A.J.L. Scheer et al.   SLEEP

Nocturnal polysomnographic sleep across the menstrual cycle in premenstrual dysphoric disorder

(2012) Ari Shechter et al.   SLEEP MEDICINE

The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing

(2012) Oliver Rawashdeh et al.   Frontiers in Molecular Neuroscience

A connection between MAPK pathways and circadian clocks

(2011) Renato M. de Paula et al.   CELL CYCLE

Light and melatonin schedule neuronal differentiation in the habenular nuclei

(2011) Nancy Hernandez de Borsetti et al.   DEVELOPMENTAL BIOLOGY

Insights into the redox cycle of human quinone reductase 2

(2011) Karine Reybier et al.   FREE RADICAL RESEARCH

Promotion of Non-Rapid Eye Movement Sleep and Activation of Reticular Thalamic Neurons by a Novel MT2 Melatonin Receptor Ligand

(2011) R. Ochoa-Sanchez et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

(2011) Sergio A. Rosales-Corral et al.   JOURNAL OF PINEAL RESEARCH

Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation

(2011) R Santoro et al.   ONCOGENE

Shift work and cancer – considerations on rationale, mechanisms, and epidemiology

(2011) Giovanni Costa et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

(2010) David K. Welsh et al.   Annual Review of Physiology

Melatonin: A pleiotropic molecule regulating inflammation

(2010) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

DAILY VARIATION OF CONSTITUTIVELY ACTIVATED NUCLEAR FACTOR KAPPA B (NFKB) IN RAT PINEAL GLAND

(2010) Erika Cecon et al.   CHRONOBIOLOGY INTERNATIONAL

Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease

(2010) Hongwen He et al.   Current Neuropharmacology

Treatment of Shift Work Disorder and Jet Lag

(2010) Phyllis C. Zee et al.   Current Treatment Options in Neurology

Emerging new sites for adult neurogenesis in the mammalian brain: a comparative study between the hypothalamus and the classical neurogenic zones

(2010) Martine Migaud et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Angiotensin I–Converting Enzyme Inhibitors Are Allosteric Enhancers of Kinin B1 and B2 Receptor Function

(2010) Ervin G. Erdös et al.   HYPERTENSION

Preclinical Drug Evaluation for Combination Therapy in Acute Stroke Using Systematic Review, Meta-Analysis, and Subsequent Experimental Testing

(2010) Victoria E O'Collins et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic treatment with melatonin stimulates dendrite maturation and complexity in adult hippocampal neurogenesis of mice

(2010) Gerardo Ramirez-Rodriguez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)

(2010) Anna Leja-Szpak et al.   JOURNAL OF PINEAL RESEARCH

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

(2010) M. L. Dubocovich et al.   PHARMACOLOGICAL REVIEWS

Intrinsically Photosensitive Retinal Ganglion Cells

(2010) Michael Tri Hoang Do et al.   PHYSIOLOGICAL REVIEWS

Practical Interventions to Promote Circadian Adaptation to Permanent Night Shift Work: Study 4

(2009) Mark R. Smith et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Pineal volume and circadian melatonin profile in healthy volunteers: An interdisciplinary approach

(2009) Ingo Nölte et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model

(2009) Kyung Hee Jung et al.   JOURNAL OF PINEAL RESEARCH

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice

(2009) Gerardo Ramírez-Rodríguez et al.   NEUROPSYCHOPHARMACOLOGY

Constant light induces alterations in melatonin levels, food intake, feed efficiency, visceral adiposity, and circadian rhythms in rats

(2009) Cyrilla H. Wideman et al.   NUTRITIONAL NEUROSCIENCE

Studies of the melatonin binding site location onto quinone reductase 2 by directed mutagenesis

(2008) Jean A. Boutin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

(2008) R Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

ACE Activity Is Modulated by Kinin B 2 Receptor

(2008) Regiane A. Sabatini et al.   HYPERTENSION

Chronic CXCL10 alters the level of activated ERK1/2 and transcriptional factors CREB and NF-κB in hippocampal neuronal cell culture

(2008) Hilda Bajova et al.   JOURNAL OF NEUROIMMUNOLOGY

Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice

(2008) Ertugrul Kilic et al.   JOURNAL OF PINEAL RESEARCH

Melatonin decreases TLR3-mediated inflammatory factor expression via inhibition of NF-B activation in respiratory syncytial virus-infected RAW264.7 macrophages

(2008) Sheng-Hai Huang et al.   JOURNAL OF PINEAL RESEARCH

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS

Effect of Melatonin and Melatonylvalpromide on β-amyloid and Neurofilaments in N2a Cells

(2008) Xiao-Chuan Wang et al.   NEUROCHEMICAL RESEARCH

Role for the Pineal and Melatonin in Glucose Homeostasis: Pinealectomy Increases Night-Time Glucose Concentrations

(2003) S. E. La Fleur et al.   JOURNAL OF NEUROENDOCRINOLOGY