Journal
INVERTEBRATE NEUROSCIENCE
Volume 19, Issue 3, Pages -Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10158-019-0227-9
Keywords
Helix; Serotonin; Memory reactivation; Reinforcement; Protein-kinase M zeta; Anisomycin
Categories
Funding
- Russian Foundation for Basic Research [17-04-01175, 17-00-00216]
- Russian Science Foundation [19-75-10067]
- Russian Science Foundation [19-75-10067] Funding Source: Russian Science Foundation
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In the present study, we tested possible ways of modification of the context long-term memory using the reconsolidation as a tool. Recently, using a depletion of the serotonin content, it was shown that the reinforcing neurotransmitter serotonin is necessary for successful repeated reconsolidation of context memory in terrestrial snails Helix lucorum (Balaban et al. in Sci Rep 6:36933, 2016), and in the present study, we investigated effects of serotonin increase in memory maintenance by injection of the serotonin precursor 5-hydroxytryptophan (5-HTP). We studied reinstatement of the context memory after its impairment during reconsolidation with a protein synthesis blocker anisomycin (ANI) or with a specific inhibitor of protein-kinase M zeta (ZIP). It was observed that applications of 5-HTP alone, known to increase the release of serotonin, or reactivation of memory alone did not restore the ZIP- or ANI-impaired context memory, while combination of the 5-HTP+reactivation of memory effectively reinstated the context memory. The data obtained confirmed the assumption that serotonin/reinforcing transmitter is a part of successful reconsolidation necessary for memory maintenance, demonstrated possible ways of long-term memory regulation during the reconsolidation process.
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